Dextran vs Albumin Haemodilution in Hip Surgery

Couderc, E.; Desmonts, J. M.; Barbier-Bohm, G.; Videcoq, M.; Berger, Jay

doi:10.1007/978-3-642-68690-0_42

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“…Rose and Coutsoftides (1981) indicated that normovolaemic haemodilution in elderly patients caused an increase in cardiac output to compensate for the diminished oxygen content of the blood. The increase in cardiac output and the concurrent decrease in systemic vascular resistance after haemodilution (Couderc et al, 1982) may enhance renal blood flow and the subsequent elimination of the drug. This finding may be particularly pertinent since, with patients in group I, meticulous care was taken to maintain cardiac output and renal blood flow.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Alcuronium in Elderly Patients Undergoing Total Hip Replacement or Aortic Reconstructive Surgery

Stephens¹,

Holloway³

et al. 1984

British Journal of Anaesthesia

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The pharmacokinetic behaviour of alcuronium was studied in three patients undergoing resection of an aortic aneurysm, and in another two patients undergoing total hip replacement (group I). A control group of five elderly patients undergoing relatively minor surgery was included (group II). In group I patients, the values of the pharmacokinetic parameters such as plasma clearance, elimination half-life and the apparent volume of distribution of the drug were found to be comparable to those obtained in normal young patients in previous studies. The group II patients, however, were found to have a prolonged elimination half-life as a result of reduced plasma clearance, possibly an age-related effect. The differences between these two groups of patients may be explained by the differences in the extent of haemorrhage and fluid replacement or changes in blood circulation, or both. However, alcuronium must still be used cautiously in both groups of patients, especially in the light of a recent finding that patients undergoing aortic reconstructive surgery have a high frequency of functional renal failure after operation.

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Section: Discussionmentioning

confidence: 99%