Dextromethorphan O-demethylation polymorphism in Jordanians

Abstract

The O-demethylation of dextromethorphan (DMT) to dextrorphan (DRP) was studied in 241 unrelated, healthy Jordanian volunteers (171 males, 70 females). Urine was collected for 8 h following a single oral dose of DMT bromhydrate 30 mg. A thin-layer chromatographic (TLC) technique was used to identify the metaboliser phenotype. The frequency of the poor metaboliser phenotype was found to be 2.9% (approximate 95% confidence interval 0.8-5.0%). Applying the Hardy-Weinberg Law, the frequency of the recessive autosomal gene controlling poor metabolism was 0.17 (95% confidence interval 0.108-0.232).

Effects of Dietary Broccoli on Human in Vivo Caffeine Metabolism: A Pilot Study on a Group of Jordanian Volunteers

“…Few studies on drug metabolism have been conducted on the Jordanian population. These studies examined the N-acetylation phenotyping using dapsone [18], acetylator phenotypes in Jordanian diabetics [19], S-mephenytoin hydroxylation which is considered as a standard CYP2C19 phenotyping probe [20,21] and genetic polymorphism of CYP2D6 [22,23] and CYP2A6 activities in a Jordanian population [24]. Jordanian population has not been screened for CYP activities or the effect of food on these activities.…”