DFT computational studies, biological and antioxidant activities, and kinetic of thermal decomposition of 1,10-phenanthroline lanthanide complexes

Taha, Ziyad A.; Ajlouni, Abdulaziz M.; Ababneh, Taher S.; Momani, Waleed; Hijazi, Ahmed K.; Masri, Mahmoud Al; Hammad, H. A.

doi:10.1007/s11224-017-0975-2

Cited by 21 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After complexation this peak was found to be shifted to lower wavenumber and appeared at around 1542 cm −1 , indicating the involvement of the nitrogen atom of the azomethine group in the coordination. The new absorption band at 418 cm −1 was assigned to the ν(Ln─ N) stretching mode, this assignment further supporting the coordination of the imine nitrogen atom to the central metal ion . The band at 908 cm −1 for the free ligand due to ν(N─ N) stretching was shifted to 921 cm −1 upon complexation.…”

Section: Resultsmentioning

confidence: 56%

A series of lanthanide complexes with 2‐fluoro‐N'‐(furan‐2‐ylmethylene) benzohydrazide ligand: Synthesis, characterization, luminescent properties and biological evaluation

Ajlouni

Taha

Hijazi

et al. 2018

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

Lanthanide (III) complexes were synthesized with Schiff base ligand 2-fluoro-N′-(furan-2-ylmethylene) benzohydrazide (L). These complexes were characterized using elemental analysis, molar conductivity measurements, spectral analysis, luminescence and thermogravimetric analysis. The Schiff base ligand is a tridentate chelate and coordinates to the central lanthanide ion with 1:2 metalto-ligand ratio. The conductivity data show a 1:1 electrolytic nature with general formula [LnL 2 (NO 3 ) 2 ]NO 3 . Eu and Tb complexes exhibit the characteristic luminescence emissions of the central metal ions attributed to efficient energy transfer from the ligand to the metal centre. Most of the complexes exhibit antibacterial activity against a number of pathogenic bacteria. Furthermore, the antioxidant activity of the ligand and its Ln (III) complexes was determined using a radical scavenging method, which indicates that the Ln (III) complexes exhibit more effective antioxidant activity than the ligand.

show abstract

Section: Resultsmentioning

confidence: 56%

A series of lanthanide complexes with 2‐fluoro‐N'‐(furan‐2‐ylmethylene) benzohydrazide ligand: Synthesis, characterization, luminescent properties and biological evaluation

Ajlouni

Taha

Hijazi

et al. 2018

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

show abstract

“…The bond lengths for LnO are comparable with previously reported results of lanthanide complexes with O , O ‐ligands [ 22,30–32 ] and for LnN are also similar to previously reported bond lengths. [ 33–35 ] The OLnO bond angles are close to 90°, which indicates a distorted octahedral geometry.…”

Section: Resultsmentioning

confidence: 97%

New heteroleptic lanthanide complexes as multimodal drugs: Cytotoxicity studies, apoptosis, cell cycle analysis, DNA interactions, and protein binding

Arbănași

Musat

Mihăilă³

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

We report herein the synthesis and characterization of four new heteroleptic complexes of Sm(III), Eu(III), Gd(III), and Tb(III) with the natural flavonoid 5-hydroxyflavone (primuletin) and 1,10-phenanthroline. According to the physicochemical characterization, the mononuclear complexes correspond to the general formula [Ln(OH) 2 L 1 L 2 ]ÁnH 2 O, where L 1 = C 15 H 9 O 3 (deprotonated 5-hydroxyflavone) and L 2 = C 12 H 8 N 2 (1,10-phenanthroline), Ln is the lanthanide cation, and n = 4 for Sm(III), 3.5 for Eu(III), 2 for Gd(III), and 3 for Tb(III). A six-coordinated distorted octahedron geometry was proposed for the complexes, and density functional theory (DFT) studies were used to calculate their optimized geometry. Cytotoxicity was studied using MTS assay on cervical, colorectal, colon, breast, and ovarian adenocarcinoma cell lines. Flow cytometry data were consistent with apoptotic cell death and disruption of the cell cycle in cervical and colon cancer cells. As a means to investigate the mechanism underlying the cytotoxic effects, the abilities of the complexes to interact with calf thymus DNA, human serum albumin, and transferrin have also been assessed. According to experimental and computational studies, the four lanthanide complexes act as DNA intercalators and bind strongly to serum proteins.

show abstract

“…After formation of the complexes, the absorption bands shift to 288–290 nm, which indicates that 2,4-dimethylbenzoic acid and 5,5′-dimethy-2,2′-bipyridine ligands coordinate to the Ln 3+ ions in the complexes. At the same time, the maximum absorbances (Amax) of the complexes are obviously higher than that of the ligands, indicating that the complexes have a larger conjugation system ( Taha et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Five Dinuclear Lanthanide Complexes Based on 2,4-dimethylbenzoic Acid and 5,5′-dimethy-2,2′-bipyridine: Crystal Structures, Thermal Behaviour and Luminescent Property

et al. 2021

View full text Add to dashboard Cite

A series of new complexes, [Ln (2,4-DMBA)3(5,5′-DM-2,2′-bipy)]2 (Ln = Sm(1), Eu (2)), [Pr (2,4-DMBA)3 (5,5′-DM-2,2′-bipy)]2·0.5(C2H5OH) (3), [Ln (2,4-DMBA)3 (5,5′-DM-2,2′-bipy)]2·0.5(2,4-DMBAH)·0.25(5,5′-DM-2,2′-bipy) (Ln = Tb (4), Dy (5)) (2,4-DMBA = 2,4-dimethylbenzoate, 5,5′-DM-2,2′-bipy = 5,5′-dimethy-2,2′-bipyridine) were synthesized via hydrothermal reaction conditions. The complexes were characterized through elemental analysis, Infrared spectra (IR), Raman (R) spectra, UV-Vis spectra, single X-ray diffraction. Single crystal data show that complexes 1–5 are binuclear complexes, but they can be divided into three different crystal structures. The thermal decomposition mechanism of complexes 1–5 were investigated by the technology of simultaneous TG/DSC-FTIR. What’s more, the luminescent properties of complexes 1–2 and 4 were discussed, and the luminescence lifetime (τ) of complexes 2 and 4 were calculated.

show abstract

DFT computational studies, biological and antioxidant activities, and kinetic of thermal decomposition of 1,10-phenanthroline lanthanide complexes

Cited by 21 publications

References 40 publications

A series of lanthanide complexes with 2‐fluoro‐N'‐(furan‐2‐ylmethylene) benzohydrazide ligand: Synthesis, characterization, luminescent properties and biological evaluation

A series of lanthanide complexes with 2‐fluoro‐N'‐(furan‐2‐ylmethylene) benzohydrazide ligand: Synthesis, characterization, luminescent properties and biological evaluation

New heteroleptic lanthanide complexes as multimodal drugs: Cytotoxicity studies, apoptosis, cell cycle analysis, DNA interactions, and protein binding

Five Dinuclear Lanthanide Complexes Based on 2,4-dimethylbenzoic Acid and 5,5′-dimethy-2,2′-bipyridine: Crystal Structures, Thermal Behaviour and Luminescent Property

Contact Info

Product

Resources

About