DFU-Helper: An Innovative Framework for Longitudinal Diabetic Foot Ulcer Diseases Evaluation Using Deep Learning

Abstract

Diabetes affects roughly 537 million people, and is predicted to reach 783 million by 2045. Diabetes Foot Ulcer (DFU) is a major complication associated with diabetes and can lead to lower limb amputation. The rapid evolution of diabetic foot ulcers (DFUs) necessitates immediate intervention to prevent the severe consequences of amputation and related complications. Continuous and meticulous patient monitoring for individuals with diabetic foot ulcers (DFU) is crucial and is currently carried out by medical practitioners on a daily basis. This research article introduces DFU-Helper, a novel framework that employs a Siamese Neural Network (SNN) for accurate and objective assessment of the progression of diabetic foot ulcers (DFUs) over time. DFU-Helper provides healthcare professionals with a comprehensive visual and numerical representation in terms of the similarity distance of the disease, considering five distinct disease conditions: none, infection, ischemia, both (presence of ischemia and infection), and healthy. The SNN achieves the best Macro F1-score of 0.6455 on the test dataset when applying pseudo-labeling with a pseudo-threshold set to 0.9. The SNN is used in the process of creating anchors for each class using feature vectors. When a patient initially consults a healthcare professional, an image is transmitted to the model, which computes the distances from each class anchor point. It generates a comprehensive table with corresponding figures and a visually intuitive radar chart. In subsequent visits, another image is captured and fed into the model alongside the initial image. DFU-Helper then plots both images and presents the distances from the class anchor points. Our proposed system represents a significant advancement in the application of deep learning for the longitudinal assessment of DFU. To the best of our knowledge, no existing tool harnesses deep learning for DFU follow-up in a comparable manner.