Background: Hemorrhoids or piles are one of the most common afflictions of human being, affecting both sexes & can occur at any age. The aim of the study was to study the effectiveness of suture ligation of hemorrhoids and mucopexy as an outpatient treatment for symptomatic hemorrhoids.Methods: This prospective observational study was carried out in the department of surgery, Gandhi Medical College, Bhopal, Madhya Pradesh, India on 64 adult patients of hemorrhoids treated by suture ligation of hemorrhoid pedicle without Doppler guidance and mucopexy from July 2012 to December 2014. The patients were managed as outpatient or day care cases. The observations and follow up data were recorded and descriptive analysis was done to study the clinical presentation of hemorrhoid disease and effectiveness of hemorrhoid ligation and mucopexy in an ambulatory, outpatient or day care setting.Results: Total 64 patients of hemorrhoids who underwent suture ligation of hemorrhoids and mucopexy were studied. Most of the patients were between 31- 60 years of age (74.28%) with males predominance (64.06%). All the patients in this study had bleeding per rectum as the main symptom. All patients had hemorrhoids in primary 3, 7 or 11 ‘o clock positions and 21 patients (32.8%) had secondary hemorrhoids as well. Majority the patients had 1-3 degree hemorrhoids. However hemorrhoid ligation was also done in 7 patients with fourth degree hemorrhoid who were severely anemic and unfit for surgery due to co morbidities. Over all 82.81% patients were free from symptoms at 1 year follow up after the procedure and only 7.81% of the patients had recurrence of bleeding or prolapse.Conclusions: Hemorrhoid suture ligation with mucopexy is a simple, safe & cost-effective ambulatory treatment for the patients of symptomatic hemorrhoids. Overall the results of hemorrhoid ligation and mucopexy were satisfactory with good control of patients complains.