DHA-enriched phosphatidylcholine from <i>Clupea harengus</i> roes regulates the gut–liver axis to ameliorate high-fat diet-induced non-alcoholic fatty liver disease

Li, Qian; Tian, Shanshan; Su, Jian; Tang, Yunping; Han, Tao

doi:10.1039/d2fo02672d

Cited by 13 publications

(6 citation statements)

References 60 publications

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“…Moreover, we found the abundance of Lachnospiraceae_NK4A136_group was sharply increased after FMT. Lachnospiraceae_NK4A136_group as a butyrate-producing bacterium could maintain intestinal barrier integrity and protect against obesity [44]. These results showed that SB positively regulated the gut microbiota composition and improved bacteria diversity.…”

Section: Discussionmentioning

confidence: 76%

The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota

Xiao,

Ruan,

et al. 2023

Foods

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Sodium benzoate (SB) is a common food preservative widely used in the food industry. However, the effects of SB intake on host health at different stages were still unclear. Hence, we investigated the impact of SB with three concentrations (150 mg/kg, 500 mg/kg and 1000 mg/kg) and at three stages (intake for 5-weeks, intake for 10-weeks and removal for 5 weeks) on host health in normal mice. The results showed that SB intake for 5 weeks slightly changed gut microbiota composition, but it significantly increased TG (only 150 mg/kg and 1000 mg/kg) and blood glucose levels (only 500 mg/kg) and promoted the secretion of interleukin (IL)-1β and IL-6 (p < 0.01). However, SB intake for 10 weeks mostly maintained normal glucolipid metabolism; although, IL-1β (p < 0.01) and IL-6 (p < 0.05) levels were also significantly increased and positively regulated the gut microbiota by significantly increasing the relative abundance of Lactobacillus and significantly decreasing the relative abundance of Ileibacterium. Meanwhile, the safety of SB for host metabolism and gut microbiota was also confirmed via a fecal microbiota transplantation experiment. In addition, we found that SB removal after 10 weeks of intake significantly increased the levels of blood glucose, insulin and HOMA-IR index, which might be attributed to gut microbiota dysbiosis. Mechanistically, these positive effects and negative effects had no close relationship with the concentration of short-chain fatty acids in the gut, which might be associated with metabolites of SB or special bacterial strains. In short, this work provided positive evidence for the safety of SB consumption within the recommended range.

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Section: Discussionmentioning

confidence: 76%

The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota

Xiao,

Ruan,

et al. 2023

Foods

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“…Colidextribacter , an HFD-dependent species, could be promoted by a high-fat and high-cholesterol diet [ 47 , 48 ]. A higher abundance of Clostridia_UCG-014 induced by a HFD was also observed [ 49 ]. However, it was found to have a negative association with serum lipid levels [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Perturbation in Early Life Could Influence Pediatric Blood Pressure Regulation in a Sex-Dependent Manner in Juvenile Rats

Yang

Zhou

et al. 2023

Nutrients

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The present study aimed to investigate whether gut dysbiosis induced by ceftriaxone in early life could influence pediatric blood pressure regulation in childhood with or without exposure to a high-fat diet (HFD). Sixty-three newborn pups of Sprague-Dawley rats were administered ceftriaxone sodium or saline solution until weaning at 3 weeks, and the rats were fed a HFD or regular diet from 3 to 6 weeks. Tail-cuff blood pressure, the expression levels of genes of the renin-angiotensin system (RAS), the concentrations of IL-1β, IL-6, and TNF-α in the colon and prefrontal cortex, and the composition of fecal microbiota were analyzed. Ceftriaxone treatment significantly increased the diastolic blood pressure of male rats at 3 weeks. At 6 weeks, systolic blood pressure (SBP) was significantly increased only in ceftriaxone treated male rats fed with HFD. The RAS showed increased activation in the kidney, heart, hypothalamus, and thoracic and abdominal aorta of male rats, but only in the kidney, heart, and hypothalamus of female rats. HFD-fed female rats showed a decreased level of IL-6 in the colon. α diversity of gut microbiota decreased and the Firmicutes to Bacteroidetes ratio increased in both male and female rats at 3 weeks; however, these parameters recovered to various degrees in female rats at 6 weeks. These results revealed that early-life gut dysbiosis induced by antibiotics combined with a HFD in childhood could be involved in pediatric blood pressure regulation and an increase in SBP in juvenile rats, and these effects occurred in a sex-dependent manner.

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“…The Lachnospiraceae NK4A136 group is considered a probiotic strain. Its relative abundance is reduced in DSS-induced colitis [ 57 , 58 , 59 ], in acetic acid-induced colitis [ 60 ], and in lipopolysaccharide (LPS)-induced intestinal mucosal injury [ 61 ], as well as in obese [ 62 , 63 , 64 , 65 ] and peanut-allergic mice [ 66 ]. A2 strain also belongs to the Lachnospiraceae family, but is less known.…”

Section: Discussionmentioning

confidence: 99%

Chronic Exposure to Both Electronic and Conventional Cigarettes Alters Ileum and Colon Turnover, Immune Function, and Barrier Integrity in Mice

Djouina,

Ollivier,

Waxin

et al. 2024

JoX

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Although the effects of cigarette smoke (CS) on the development of several intestinal diseases is well documented, the impact of e-cigarette aerosol (e-cig) on digestive health is largely unknown. To compare the effects of e-cig and CS on mouse ileum and colon, animals were chronically exposed for 6 months by nose-only inhalation to e-cig at 18 or 30 W power, or to 3R4F CS. Results showed that e-cig exposure decreased colon cell proliferation. Several other proliferative defects were observed in response to both e-cig and CS exposure, including up- and down-regulation of cyclin D1 protein levels in the ileum and colon, respectively. E-cig and CS exposure reduced myeloperoxidase activity in the ileum. In the colon, both exposures disrupted gene expression of cytokines and T cell transcription factors. For tight junction genes, ZO-1- and occludin-protein expression levels were reduced in the ileum and colon, respectively, by e-cig and CS exposure. The 16S sequencing of microbiota showed specific mild dysbiosis, according to the type of exposure. Overall, e-cig exposure led to altered proliferation, inflammation, and barrier function in both the ileum and colon, and therefore may be a gut hazard on par with conventional CS.

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DHA-enriched phosphatidylcholine from Clupea harengus roes regulates the gut–liver axis to ameliorate high-fat diet-induced non-alcoholic fatty liver disease

Abstract: In this study, the protective effect of DHA-enriched phosphatidylcholine (DHA-PC) from Clupea harengus roes against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) was investigated. Our results indicated that DHA-PC...

Cited by 13 publications

References 60 publications

The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota

The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota

Gut Microbiota Perturbation in Early Life Could Influence Pediatric Blood Pressure Regulation in a Sex-Dependent Manner in Juvenile Rats

Chronic Exposure to Both Electronic and Conventional Cigarettes Alters Ileum and Colon Turnover, Immune Function, and Barrier Integrity in Mice

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