DHA-rich fish oil and Tualang honey reduce chronic stress-induced oxidative damage in the brain of rat model

Asari, Mohd Asnizam; Sirajudeen, K. N. S.; Yusof, Nurul Aiman Mohd; Amin, Mohamad Syabil Ikhwan Mohd

doi:10.1016/j.jtcme.2021.10.001

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…In our study, CRS increased lipid peroxidation, which reflects the increasing ROS production. This finding is in concordance with previous studies demonstrating that oxidative stress markers are increased in the hippocampus, 13,14 penile tissue, 10 brain, 63 serum, 13 and hearts 12 of animals with chronic stress. Indeed, the activity of superoxide dismutase and catalase, antioxidant enzymes, is decreased during chronic stress.…”

Section: Nahs Administration Alleviates Oxidative Stress and Redox En...supporting

confidence: 93%

Sodium Hydrosulfide Reverts Chronic Stress–Induced Cardiovascular Alterations by Reducing Oxidative Stress

Beltran-Ornelas,

Silva-Velasco,

Tapia-Martínez

et al. 2024

Journal of Cardiovascular Pharmacology

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Chronic stress induces a group of unrecognized cardiovascular impairments, including elevated hemodynamic variables and vascular dysfunction. Moreover, hydrogen sulfide (H2S), a gasotransmitter that regulates the cardiovascular system, decreases under chronic stress. Thus, this study assessed the impact of NaHS (H2S donor) on chronic restraint stress (CRS)-induced cardiovascular changes. For that purpose, male Wistar rats were restrained for 2 h in a transparent acrylic tube over eight weeks. Then, body weight, relative adrenal gland weight, serum corticosterone, H2S-synthesizing enzymes, eNOS expression, reactive oxygen species (ROS) levels, lipid peroxidation, and reduced glutathione/oxidized glutathione (GSH2/GSSG) ratio, were determined in the thoracic aorta. The hemodynamic variables were measured in vivo by the plethysmograph method. The vascular function was evaluated in vitro as vasorelaxant responses induced by carbachol (CCh) or sodium nitroprusside, and norepinephrine (NE)-mediated vasocontractile responses in the thoracic aorta. CRS increased: (1) relative adrenal gland weight; (2) hemodynamic variables; (3) vasoconstrictor responses induced by NE, (4) ROS levels, and (5) lipid peroxidation in the thoracic aorta. Additionally, CRS decreased: (1) body weight; (2) vasorelaxant responses induced by CCh; (3) GSH content and (4) GSH2/GSSG ratio. Notably, NaHS administration (5.6 mg/kg) restored hemodynamic variables, lipid peroxidation and attenuated the vasoconstrictor responses induced by NE in the thoracic aorta. In addition, NaHS treatment increased relative adrenal gland weight and the GSH2/GSSG ratio. Taken together, our results demonstrate that NaHS alleviates CRS-induced hypertension by reducing oxidative stress and restoring vascular function in the thoracic aorta.

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Section: Nahs Administration Alleviates Oxidative Stress and Redox En...supporting

confidence: 93%

Sodium Hydrosulfide Reverts Chronic Stress–Induced Cardiovascular Alterations by Reducing Oxidative Stress

Beltran-Ornelas,

Silva-Velasco,

Tapia-Martínez

et al. 2024

Journal of Cardiovascular Pharmacology

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“…MBS extracted from Phaeophycea show antibacterial, anticoagulant, antithrombotic, antitumor, antiviral, and antiinflammatory properties (Achmad et al, 2020b;Leal et al, 2018;Ren et al, 2019). Additionally, several biopolymers and bioactive substances, such as chitosan, COL, and fish oil, are extracted from Chordata and exhibit antioxidant, antimicrobial, and antiinflammatory activities and biocompatibility (Asari et al, 2021;Oh et al, 2021;Satpathy et al, 2021). Arenicola marina inhabits intertidal soft sediments from the Arctic to the Mediterranean and contains peptides and extracellular hemoglobin with antimicrobial and anti-hepatotoxicity activities (De Cubber et al, 2019;Le Daré et al, 2021;Umnyakova et al, 2018).…”

Section: Trend Analysis On Extraction Source Of Marine Bioactive Subs...mentioning

confidence: 99%

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Lee¹,

Kwon²,

Jung³

2023

Fish Aquat Sci

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Marine bioactive substances (MBS), such as phlorotannins, collagens, peptides, sterols, and polysaccharides, are increasing attention as therapeutic agents for several diseases due to their pharmacological effects. Previous studies have demonstrated the biological activities of MBS including antibacterial, anticoagulant, antidiabetic, antimicrobial, anti-inflammatory activities. Among numerous human diseases, periodontitis is one of the high-prevalence inflammatory diseases in the world. To treat periodontitis, several surgeries (bone grafting, flap surgery, and soft tissue graft) are usually used. However, the surgery for patients with chronic periodontitis induces several side effects, including additional inflammatory responses at the operated site, chronic wound healing, and secondary surgery. Therefore, this review assessed the most recent trends in MBS using Google Scholar, PubMed, and Web of Science search engines to develop marine-derived therapeutic agents for periodontitis. Further, we summarized the current applications and therapeutic potential of MBS to serve as a reference for developing novel technologies applied to MBS against periodontitis treatment.

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“…for3 months reduced the level of thiobarbituric acid-reactive substances, a lipid peroxidation marker, in police dogs; meanwhile, the activity of glutathione peroxidase (GPx) was elevated compared with dogs consuming a normal diet (Ravic et al, 2022). Another study administered DHA-enriched fish oil (450 mg/kg body weight twice daily) to stress-induced brain oxidative stress model mice; the authors disclosed a lower level of serum lipid peroxidation and a higher level of serum total antioxidant capacity (Asari et al, 2022).…”

Section: Omega-3fattyacidsmodulateoxidative Stressmentioning

confidence: 99%

“…One study reported that consuming a diet enriched with omega‐3 fatty acids (containing 2.68% EPA and 3.17% DHA) for3 months reduced the level of thiobarbituric acid–reactive substances, a lipid peroxidation marker, in police dogs; meanwhile, the activity of glutathione peroxidase (GPx) was elevated compared with dogs consuming a normal diet (Ravic et al, 2022). Another study administered DHA‐enriched fish oil (450 mg/kg body weight twice daily) to stress‐induced brain oxidative stress model mice; the authors disclosed a lower level of serum lipid peroxidation and a higher level of serum total antioxidant capacity (Asari et al, 2022). Meanwhile, in rats fed a high‐fat diet, the addition of omega‐3 fatty acids (50.79 mol% DHA + EPA) reduced lipid peroxidation levels and increased GPx activity (Miralles‐Perez et al, 2021).…”

Section: Potential Involvement Of Omega‐3 Fatty Acids In Rmmentioning

confidence: 99%

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

Huo

Wang

et al. 2023

Food Science & Nutrition

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Recurrent miscarriage (RM) affects approximately 1%–5% of couples worldwide. Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery for anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs for hyperthyroidism and hypothyroidism, and aspirin and low molecular weight heparin for antiphospholipid syndrome. However, these treatment modalities are still insufficient to solve RM. Omega‐3 fatty acids are reported to modulate the dysregulation of immune cells, oxidative stress, endocrine disorders, inflammation, etc., which are closely associated with the pathogenesis of RM. However, there is a lack of a systematic description of the involvement of omega‐3 fatty acids in treating RM, and the underlying mechanisms are also not clear. In this review, we sought to determine the potential mechanisms that are highly associated with the pathogenesis of RM and the regulation of omega‐3 fatty acids on these mechanisms. In addition, we also highlighted the direct and indirect clinical evidence of omega‐3 fatty acid supplements to treat RM, which might encourage the application of omega‐3 fatty acids to treat RM, thus improving pregnancy outcomes.

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DHA-rich fish oil and Tualang honey reduce chronic stress-induced oxidative damage in the brain of rat model

Cited by 11 publications

References 36 publications

Sodium Hydrosulfide Reverts Chronic Stress–Induced Cardiovascular Alterations by Reducing Oxidative Stress

Sodium Hydrosulfide Reverts Chronic Stress–Induced Cardiovascular Alterations by Reducing Oxidative Stress

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

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