DHEA supplementation improves follicular microenviroment in poor responder patients

Abstract

The improvement of reproductive parameters after DHEA supplementation in poor responders may be explained through the effect that this pro-hormone exerts on follicular microenvironment.

Impact of dehydroepiandrosterone on clinical outcome in poor responders: A pilot study in women undergoing in vitro fertilization, using bologna criteria

“…[1011132034] We believe that it reflects the occurrence of POR earlier in women studied, as has been documented previously in certain ethnicities. [3] This study did not show any improvement in cycle parameters such as duration of treatment or dose of gonadotropins, as has been documented previously and only a nonsignificant reduction in cancellation rate.…”

“…[3] This study did not show any improvement in cycle parameters such as duration of treatment or dose of gonadotropins, as has been documented previously and only a nonsignificant reduction in cancellation rate. [1020] Unlike previous reports, the changes noted in peak E2 levels were only modest. [2022] Shorter duration of DHEA supplementation compared to previous studies may explain these findings.…”

“…[1020] Unlike previous reports, the changes noted in peak E2 levels were only modest. [2022] Shorter duration of DHEA supplementation compared to previous studies may explain these findings. [102022] However, it is known that parameters like improvement in oocyte quality leading to a reduction in aneuploidy may be seen with a shorter duration of supplementation.…”

“…[81519] Recently, DHEA is shown to improve the follicular microenvironment by lowering the levels of hypoxic inducible factor 1. [20] Its beneficial effect may be due to rescue of small antral follicles from atresia measured as an increase in the antral follicle count (AFC) and ovarian volume. [2122] However, it may also act by increasing the recruitment of preantral or small antral follicles seen as an increase in anti-Mullerian hormone (AMH).…”

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

“…In women with reduced ovarian reserve, different regiments of DHEA were applied with some of them showing an improvement in pregnancy rates (137). In the study on women labeled as 'poor responders', daily administration of 75 mg of DHEA during three months led to an increased number of mature oocytes and a significant reduction in the concentration of hypoxia inducible factor 1 (HIF-1) in the follicular fluid (138). This is leading to the conclusion that DHEA could influence on the follicular microenvironment.…”