DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells

Upmanyu, Neha; Bulldan, Ahmed; Failing, Klaus; Scheiner‐Bobis, Georgios

doi:10.1016/j.bbamcr.2019.118600

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Our results demonstrated that a RET protocol could significantly reduce DHEA-S and cortisol/DHEA-S levels, regardless of HT, with a possible protective role on cancer relapse, as androgen receptors modulate BC cell growth both with a genomic and nongenomic pathway [74]. However, these results should be confirmed and analyzed at a long-term follow-up, as a potential anti-metastatic role for DHEA-S in BC has been recently advocated [75].…”

Section: Discussionmentioning

confidence: 60%

Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study

Bucciarelli

Bianco

Blasio

et al. 2023

JCM

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Background: Breast cancer (BC) and cardiovascular (CV) disease share many risk factors associated with worse outcomes, in terms of cancer relapse, CV events, and quality of life (QoL), that could be counteracted by physical exercise (PE). We aimed to assess the impact of a 12-week differential PE protocol on cardiometabolic profile, QoL, CV- and BC-related long-term outcomes, and physical activity (PA) in a cohort of BC survivors (BCS) not treated with chemotherapy. Methods: 57 BCS participated in a 12-week PE protocol [aerobic exercise training (AET) or resistance exercise training (RET)]. Anthropometric and CV evaluation, health-related (HR)-QoL, daily PA, cortisol, and dehydroepiandrosterone sulfate (DHEA-S) levels were assessed before (T0) and after (T1) PE. We assessed BC and CV outcomes, HR-QoL, CV-QoL, and PA at the follow-up. Results: RET improved waist circumference, DHEA-S, cortisol/DHEA-S, systolic and mean blood pressure, and ventricular/arterial coupling; AET ameliorated sagittal abdomen diameter and pulse wave velocity. Regarding HR-QoL, physical function improved only in AET group. At a mean 34 ± 3.6-month follow-up, we documented no significant differences in CV-QoL, HR-QoL, and PA or CV and BC outcomes. Conclusions: AET and RET determine specific, positive adaptations on many parameters strongly related to CV risk, CV and BC outcomes, and QoL, and should be included in any cardio-oncology rehabilitation program.

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Section: Discussionmentioning

confidence: 60%

Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study

Bucciarelli

Bianco

Blasio

et al. 2023

JCM

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“…Osawa et al (2002) have found that DHEA increases the number of aberrant crypt foci induced by azoxymethane in a murine model without progression to carcinogenesis, suggesting that DHEA may be a promising chemopreventive drug for colon cancer. DHEAS activates ERK1/2 in MCF-7 breast cancer cells (Upmanyu et al, 2020). The ERK 1/2 cascade is a central signaling pathway that regulates various biological processes, including proliferation, differentiation, survival, apoptosis and stress response (Wortzel and Seger, 2011).…”

mentioning

confidence: 99%

Dehydroepiandrosterone Sulfate and Colorectal Cancer Risk: A Mendelian Randomization Analysis

et al. 2022

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Colorectal cancer is the third most common and second most deadly type of cancer worldwide, with approximately 1.9 million cases and 0.9 million deaths worldwide in 2020. Previous studies have shown that estrogen and testosterone hormones are associated with colorectal cancer risk and mortality. However, the potential effect of their precursor, dehydroepiandrosterone sulfate (DHEAS), on colorectal cancer risk has not been investigated. Therefore, evaluating DHEAS’s effect on colorectal cancer will expand our understanding of the hormonal contribution to colorectal cancer risk. In this study, we conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal effect of DHEAS on colorectal cancer. We obtained DHEAS and colorectal cancer genomewide association study (GWAS) summary statistics from the Leipzig Health Atlas and the GWAS catalog and conducted MR analyses using the TwoSampleMR R package. Our results suggest that higher DHEAS levels are causally associated with decreased colorectal cancer risk (odds ratio per unit increase in DHEAS levels z score = 0.70; 95% confidence interval [0.51, 0.96]), which is in line with previous observations in a case–control study of colon cancer. The outcome of this study will be beneficial in developing plasma DHEAS-based biomarkers in colorectal cancer. Further studies should be conducted to interpret the DHEAS-colorectal cancer association among different ancestries and populations.

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Dehydroepiandrosterone (DHEA) in relation to breast cancer

Chatterton

2024

Vitamins and Hormones

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DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells

Cited by 4 publications

References 46 publications

Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study

Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study

Dehydroepiandrosterone Sulfate and Colorectal Cancer Risk: A Mendelian Randomization Analysis

Dehydroepiandrosterone (DHEA) in relation to breast cancer

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