DHNTs assimilated TPU/PEG membrane a new combination for evaluation of in-vitro blood-coagulation

Bose, Neeraja; Rajappan, Kalaivizhi; Natesan, Gowriboy; Selvam, S. Periyar

doi:10.1080/00914037.2022.2066670

Cited by 3 publications

(2 citation statements)

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“…40 A short prominent peak at 530.8 eV corresponds to the C−OH group of PEG and C�O of PAN. 41 Furthermore, the depositions of MgO in the MgO/gC 3 N 4 @PAN/PEG nanofiber membrane are confirmed by the deconvoluted Mg 2p peak at a binding energy of 49.81 eV with an oxidation state of Mg 2+ as shown in Figure 6e. 42 Thus, the prepared material has all of the significant elements even after modifications.…”

Section: Sem Analysismentioning

confidence: 70%

“…The spectrum corresponds to the C–O group of PAN and the presence of the hydroxyl group of gC 3 N 4 at a binding energy of 532.82 eV; also, the GO of gC 3 N 4 shows the prominent settlement in the nanofiber membrane at a binding energy of 532.2 eV . A short prominent peak at 530.8 eV corresponds to the C–OH group of PEG and CO of PAN . Furthermore, the depositions of MgO in the MgO/gC 3 N 4 @PAN/PEG nanofiber membrane are confirmed by the deconvoluted Mg 2p peak at a binding energy of 49.81 eV with an oxidation state of Mg 2+ as shown in Figure e .…”

Section: Results and Discussionmentioning

confidence: 90%

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Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC₃N₄ Nanocomposite for Effective Bone Regeneration

Danagody,

Bose,

Rajappan

et al. 2023

ACS Biomater. Sci. Eng.

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Developing biomaterial scaffolds using tissue engineering with physical and chemical surface modification processes can improve the bioactivity and biocompatibility of the materials. The appropriate substrate and site for cell attachment are crucial in cell behavior and biological activities. Therefore, the study aims to develop a conventional electrospun nanofibrous biomaterial using reproducible surface topography, which offers beneficial effects on the cell activities of bone cells. The bioactive MgO/gC 3 N 4 was incorporated on PAN/PEG and fabricated into a nanofibrous membrane using electrospinning. The nanocomposite uniformly distributed on the PAN/PEG nanofiber helps to increase the number of induced pores and reduce the hydrophobicity of PAN. The physiochemical characterization of prepared nanoparticles and nanofibers was carried out using FTIR, X-ray diffraction (XRD), thermogravimetry analysis (TGA), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. SEM and TEM analyses examined the nanofibrous morphology and the structure of MgO/gC 3 N 4 . In vitro studies such as on ALP activity demonstrated the membrane's ability to regenerate new bone and healing capacity. Furthermore, alizarin red staining showed the increasing ability of the cell−cell interaction and calcium content for tissue regeneration. The cytotoxicity of the prepared membrane was about 97.09% of live THP-1 cells on the surface of the MgO/gC 3 N 4 @PAN/PEG membrane evaluated using MTT dye staining. The soil burial degradation analysis exhibited that the maximum degradation occurs on the 45th day because of microbial activity. In vitro PBS degradation was observed on the 15th day after the bulk hydrolysis mechanism. Hence, on the basis of the study outcomes, we affirm that the MgO/gC 3 N 4 @PAN/PEG nanofibrous membrane can act as a potential bone regenerative substrate.

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Section: Sem Analysismentioning

confidence: 70%

Section: Results and Discussionmentioning

confidence: 90%

Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC₃N₄ Nanocomposite for Effective Bone Regeneration

Danagody,

Bose,

Rajappan

et al. 2023

ACS Biomater. Sci. Eng.

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The Horizons of Medical Mineralogy: Structure-Bioactivity Relationship and Biomedical Applications of Halloysite Nanoclay

Feng,

Chen,

et al. 2024

ACS Nano

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Medical mineralogy explores the interactions between natural minerals and living organisms such as cells, tissues, and organs and develops therapeutic and diagnostic applications in drug delivery, medical devices, and healthcare materials. Many minerals (especially clays) have been recognized for pharmacological activities and therapeutic potential. Halloysite clay (Chinese medicine name: Chishizhi), manifested as onedimensional aluminum silicate nanotubes (halloysite nanotubes, HNTs), has gained applications in hemostasis, wound repair, gastrointestinal diseases, tissue engineering, detection and sensing, cosmetics, and daily chemicals formulations. Various biomedical applications of HNTs are derived from hollow tubular structures, high mechanical strength, good biocompatibility, bioactivity, and unique surface characteristics. This natural nanomaterial is safe, abundantly available, and may be processed with environmentally safe green chemistry methods. This review describes the structure and physicochemical properties of HNTs relative to bioactivity. We discuss surface area, porosity and surface defects, hydrophilicity, heterogeneity and charge of external and internal surfaces, as well as biosafety. The paper provides comprehensive guidance for the development of this tubule nanoclay and its advanced biomedical applications for clinical diagnosis and therapy.

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ACs@ZnO incorporated with a PSF/PU polymer membrane for dye removal

2022

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DHNTs assimilated TPU/PEG membrane a new combination for evaluation of in-vitro blood-coagulation

Cited by 3 publications

References 55 publications

Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC₃N₄ Nanocomposite for Effective Bone Regeneration

Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC₃N₄ Nanocomposite for Effective Bone Regeneration

The Horizons of Medical Mineralogy: Structure-Bioactivity Relationship and Biomedical Applications of Halloysite Nanoclay

ACs@ZnO incorporated with a PSF/PU polymer membrane for dye removal

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DHNTs assimilated TPU/PEG membrane a new combination for evaluation of in-vitro blood-coagulation

Cited by 3 publications

References 55 publications

Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC3N4 Nanocomposite for Effective Bone Regeneration

Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC3N4 Nanocomposite for Effective Bone Regeneration

The Horizons of Medical Mineralogy: Structure-Bioactivity Relationship and Biomedical Applications of Halloysite Nanoclay

ACs@ZnO incorporated with a PSF/PU polymer membrane for dye removal

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Product

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Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC₃N₄ Nanocomposite for Effective Bone Regeneration

Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC₃N₄ Nanocomposite for Effective Bone Regeneration