DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain

Liu, Xiaodan; Jin, Tong; Yang, Tao; Zhang, Ming; Zheng, Hong-li; Liu, Qiaoqiao; Yang, Ke; Wei, Runa; Liu, Siyuan; Huang, Yue; Xue, Zhou-Ya; Hao, Lü; Wang, Qihui; Li, Yang; Lin, Fuqing; Shen, Wen; Tao, Yuan‐Xiang; Wang, Hongjun; Cao, Jun-Li; Pan, Zengxiang

doi:10.1038/s41401-023-01082-x

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…The current study only described the modulation of hippocampal DHX9 in neuropathic pain, leaving the changes in other brain regions largely unclear. Although our previous study has revealed that dorsal horn DHX9 regulated the production of ciRNA-Fmn1 by binding to DNA-tandem repeats and contributed to the genesis of neuropathic pain, 47 the specific regulatory mechanism underlying the role of DHX9 in hippocampal synaptic plasticity in the context of neuropathic pain is elusive.…”

Section: Discussionmentioning

confidence: 97%

DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

Yang,

Liu,

Zhao

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 97%

DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

Yang,

Liu,

Zhao

et al. 2024

iScience

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“… 295 The roles of other ubiquitination enzymes, like HUWE1 and UBR5, in nociceptive and neuropathic pain modulation have been partially revealed. 296 , 297 In the present context, all the ubiquitination enzymes linked to pain modulation pertain to E3 ubiquitin ligases.…”

Section: Molecular Mechanisms Of Pain Modulationmentioning

confidence: 99%

Pathology of pain and its implications for therapeutic interventions

Cao,

Xu,

Shi

et al. 2024

Sig Transduct Target Ther

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Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is crucial for individuals suffering from pain. However, the current methods for pain assessment and treatment fall short of clinical needs. Benefiting from advances in neuroscience and biotechnology, the neuronal circuits and molecular mechanisms critically involved in pain modulation have been elucidated. These research achievements have incited progress in identifying new diagnostic and therapeutic targets. In this review, we first introduce fundamental knowledge about pain, setting the stage for the subsequent contents. The review next delves into the molecular mechanisms underlying pain disorders, including gene mutation, epigenetic modification, posttranslational modification, inflammasome, signaling pathways and microbiota. To better present a comprehensive view of pain research, two prominent issues, sexual dimorphism and pain comorbidities, are discussed in detail based on current findings. The status quo of pain evaluation and manipulation is summarized. A series of improved and innovative pain management strategies, such as gene therapy, monoclonal antibody, brain-computer interface and microbial intervention, are making strides towards clinical application. We highlight existing limitations and future directions for enhancing the quality of preclinical and clinical research. Efforts to decipher the complexities of pain pathology will be instrumental in translating scientific discoveries into clinical practice, thereby improving pain management from bench to bedside.

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The role of the ubiquitin system in the onset and reversal of neuropathic pain

Wang,

Zhang

et al. 2024

Biomedicine & Pharmacotherapy

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DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain

Cited by 4 publications

References 68 publications

DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

Pathology of pain and its implications for therapeutic interventions

The role of the ubiquitin system in the onset and reversal of neuropathic pain

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