Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms

Chen, Hao; Zhang, Wang; Rui, Bei-bei; Yang, Simin; Xu, Weiping; Wei, Wei

doi:10.1016/j.etap.2015.12.016

Cited by 76 publications

(64 citation statements)

References 38 publications

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“…There is evidence that EDCs with similar modes of action (MoAs) can act together in an additive manner to produce more pronounced effects [15]. Additionally, there are studies on different experimental models that indicate the possibility of interaction between these chemicals, i.e., suggesting even synergism in their endocrine actions [7,[16][17][18][19]. Therefore, the utilization of real-life risk simulation (RLRS) concept in determining the combined effects of such chemicals is essential [19].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.

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Section: Introductionmentioning

confidence: 99%

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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“…There are also reports about the influence of phthalates on the function of the human thyroid gland and immune system (Sathyanarayana, 2008). One of the types of phthalates (di(2-ethylhexyl) phthalate, or DEHP) causes increase in the weight of the liver, morphological and biochemical changes in it; it changes the activity of the main enzymes which metabolize medical substances and ethanol, mostly by inhibiting them (Seth, 1982;Chen et al, 2016;Liu et al, 2016). Increase of DEHP dose over 30 days caused changes in urine, which indicate the impact on energy metabolism, function of the liver and kidneys, metabolism of fatty acids and caused harm to DNA in rats (Dong et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…In chronic studies of high doses of DINP in rodents, de-crease in body weight, increase in mass of the liver and changes in histopathology of hepatocytes (hypertrophy) were observed. Prolonged impact of high doses of this substance even caused increase in frequency of tumours of the liver (adenoma and carcinoma) (Chen et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Impact of polyvinyl chloride, polystyrene, and polyethylene on the organism of mice

Lieshchova

Brygadyrenko

Tishkina

et al. 2019

Regul. Mech. Biosyst.

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Goods of plastic, due to their durability, universality and economical properties are broadly used in all spheres of life. On the whole, polymers are inert and nontoxic, but in the process of their production, various additives are used, which on contact or introduction into an organism has a negative effect on it. In our study, we determined the impact of some types of plastic (polyvinyl chloride, polysterene and polyethylene) on the organism of laboratory animals according to changes in their body weight, indices of mass of the internal organs, and blood parameters. For the experiment, we formed four groups of white male mice at the age of 3 weeks and average body weight of 50 g. For each group, we used different litter. For group I, the litter was sawdust; and for the other groups we added plastic products in different volumes to the sawdust; for group II finely cut polyvinyl chloride, for group III cut polyethylene, and for group IV granules of polystyrene. Every 3 days, we determined the body weight of the animals, and 32 days later we determined mass of the organs, clinical and biochemical parameters of the blood. Addition of polyvinyl chloride, polyethylene, and polystyrene into the substrate for mice did not have a significant effect on tempi of growth of body weight, and also relative mass of heart and lungs. Polyvinyl chloride and polystyrene have an immune-suppressive effect, and polyvinyl chloride affects both central and peripheral organs, and polystyrene mostly harms the peripheral organs. All used types of plastic cause leukocytopenia, following which neutrophilia of band neutrophils and monocytosis takes place as a result of damage to the biological barriers. We determined the systemic toxic effect of the studied types of plastic on the internal organs, which manifested in increase in their mass (liver, kidneys), steep increase in the activity of liver enzymes (AST, ALT), simultaneous decrease in activity of alkaline phosphatase and content of cholysterol and glucose in the blood serum of the mice. Also polyvinyl chlorine, polyethylene and polystyrene cause degeneration of the epithelium of the uriniferous tubule, which is manifested in reduction of globulins and creatinine in the blood of animals from the experimental groups following increase in relative mass of the kidneys. The results of our research allow us to state that different types of plastic can cause toxic effect on animals, as well as people who are in frequent contact with them.

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“…In vitro на культурі клітин 3T3-L1 встановлено, що DEHP порушує інсулінову толерантність, але не впливає на метаболізм глюкози (Klöting N. et al, 2015). В інших дослідженнях на щурах показано, що DEHP може індукувати жирову трансформацію печінки протягом 8 тиж за рахунок активації ліпопероксидації та вивільнення прозапальних факторів у гепатоцитах, що порушує синтезуючу функцію печінки (Chen H. et al, 2016).…”

Section: фталати як фактори нерепродуктивних порушеньunclassified

Фталати — Питання Біотоксичності Щодо організму Людини

Кубашко¹,

Герцюк²,

Дєєв³

2018

UMJ

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Таблиця 1. Джерела ймовірного контакту людини з найпоширенішими фталатами Фталат Абревіатура Походження Butylbenzyl phthalate BBP Вінілові покриття, клеї, герметики, промислові розчинники Din -butyl phthalate DBP Клеї, ущільнювачі, косметика, промислові розчинники, медичні препарати Dicyclohexyl phthalate DCHP Стабілізатори гуми, полімери Di-2-ethylhexyl phthalate DEHP М'який пластик і труби, іграшки, побутові продукти, харчові контейнери та упаковки Diethyl phthalate DEP Шампуні, парфуми, мила, лосьйони, косметична продукція, промислові розчинники, медичні препарати Diisobutyl phthalate DIBP Клеї, ущільнювачі, косметика, промислові розчинники Diisononyl phthalate DINP М'який пластик, замінник DEHP Dimethyl phthalate DMP Засоби від комах, пластик Dioctyl phthalate DOP М'який пластик Di-2-propylheptyl phthalate DPHP Ізоляція кабелів та проводок, брезент, покрівельні мембрани Diiusondecyl phthalate DIUP Резина, мастильні масла, ізоляція кабелів та проводок, покриття полів, стін, басейнів, покрівель і будівельних тканин, автомобільні обшивки Ditridecyl phthalate DTDP Ізоляційні матеріали для електричних та автомобільних кабелів

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Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms

Cited by 76 publications

References 38 publications

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Impact of polyvinyl chloride, polystyrene, and polyethylene on the organism of mice

Фталати — Питання Біотоксичності Щодо організму Людини

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