Di (2-ethylhexyl) phthalate induces cardiac disorders in BALB/c mice

Amara, Ines; Timoumi, Rim; Annabi, Emna; Neffati, Fadoua; Najjar, Mohamed Fadhel; Bouaziz, Chayma; Abid‐Essefi, Salwa

doi:10.1007/s11356-019-04219-w

Cited by 32 publications

(17 citation statements)

References 46 publications

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“…Additionally, the biochemical mechanism through which cardiotoxicity occurs have been reported. DEHP exposure in mice can induce oxidative stress, inhibit acetylcholinesterase activity, and lead to structural alternation of surrounding blood vessels, as reported in previous literature [13]; these disruptions provide evidence that exposure to DEHP may promote the progression of atherosclerosis. Furthermore, Ferguson and associates indicated that mono-n-butyl phthalate (MnBP), the metabolite of di-n-butyl phthalate (DnBP), and the metabolites of DEHP were significantly and positively associated with markers of oxidative stress (bilirubin) and inflammation (fibrinogen, alkaline phosphatase) based on data from participants in the National Health and Nutrition Examination Survey [14].…”

Section: Introductionsupporting

confidence: 81%

Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults

Chu

2021

Toxics

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Endothelial function is crucial in the pathogenesis of circulatory and cardiovascular toxicity; epidemiologic research investigating the association between phthalate exposure and endothelial dysfunction remains limited. We examined the associations between exposures to specific phthalates (di-2-ethylhexyl phthalate, DEHP; di-n-butyl phthalate, DnBP) and circulating endothelial and platelet microparticles (EMPs and PMPs) in adolescents and young adults. Of the 697 participants recruited, anthropometric measurements and health-related behaviors relevant to cardiovascular risks were collected and assessed. Urine and serum were collected and analyzed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and flow cytometry. Multiple linear regression indicated that increases in urinary concentrations of ΣDEHP and MnBP (mono-n-butyl phthalate), across quartiles, were positively associated with serum EMPs level (p for trend <0.001 and <0.001; β = 0.798 and 0.007; standard error = 0.189 and 0.001, respectively). Moreover, female and overweight subjects had higher MnBP, and males were more vulnerable to DnBP exposure compared to females. In conclusion, our results demonstrate a dose-response relationship between exposures to phthalates (ΣDEHP and MnBP) and microparticle formation (EMPs and PMPs) in adolescents and young adults. The findings indicate that exposures to phthalates of both low and high-molecular weight are positively associated with microparticle production, and might contribute to endothelial dysfunction; such damage might manifest in the form of atherosclerotic-related vascular diseases. Future in vivo and in vitro studies are warranted to elucidate whether a causal relationship exists between phthalate exposure and EMPs and PMPs.

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Section: Introductionsupporting

confidence: 81%

Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults

Chu

2021

Toxics

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“…Martinelli suggested that DEHP exposure to animal skeletal muscle could disrupt glucose metabolism [58]. Amara showed that DEHP exposed mice have altered lipid profiles with higher triglycerides, cholesterol and high and low lipoproteins [59]. Human children aged 6-18 exposed to the metabolite MEHP had increased obesity, triglycerides, and increased blood pressure [60].…”

Section: Metabolic and Genetic Toxicitymentioning

confidence: 99%

Reducing Toxic Phthalate Exposures in Premature Infants

Jenkins¹

2022

Topics on Critical Issues in Neonatal Care

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Phthalates are a ubiquitous group of industrial compounds used as industrial solvents and as additives to plastics to make products softer avnd more flexible. Phthalates are found in a variety of products including medical devices, personal care products, flooring, and food packaging. Infants in the neonatal intensive care unit are exposed to phthalates both in the building materials, but more importantly in the medical supplies and devices. Toxicity from phthalates has been of concern to researchers for many decades. Toxicity concerns to neonates includes male reproductive toxicity, hepatotoxicity, cardiotoxicity (including hypertension), neurotoxicity, and neurodevelopmental abnormalities. Limited recommendations have been given for reducing phthalate exposures to premature infants. These include avoiding infusing lipids or blood products through intravenous tubing containing phthalates. Storage of blood in containers made with phthalates has been a strong recommendation and has largely been accomplished. A comprehensive plan for phthalate reduction has heretofore been missing. This chapter has the goal of identifying the problem of phthalate exposure in premature infants, with some practical solutions that can be done today, as well as suggestions for manufacturers to complete the work.

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“…Given its interaction with PPAR nuclear receptors, this is one potential mechanism by which DEHP exposure can disrupt energy metabolism and contribute to metabolic disorders. Indeed, Amara et al reported that DEHP exposure (5–200 mg/kg) altered the serum lipid profile of mice by increasing total cholesterol, triglycerides, low and high density lipoproteins (Amara et al, 2019). The authors also reported an increase in inflammatory and oxidative stress markers, which coincided with increased myocardial injury in DEHP‐treated animals.…”

Section: Di‐2‐ethylhexyl Phthalatementioning

confidence: 99%

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

Ramadan

Cooper

Posnack

2020

Birth Defects Research

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Phthalates and bisphenols are high production volume chemicals that are used in the manufacturing of consumer and medical products. Given the ubiquity of bisphenol and phthalate chemicals in the environment, biomonitoring studies routinely detect these chemicals in 75-90% of the general population. Accumulating evidence suggests that such chemical exposures may influence human health outcomes, including cardiovascular health. These associations are particularly worrisome for sensitive populations, including fetal, infant and pediatric groups-with underdeveloped metabolic capabilities and developing organ systems. In the presented article, we aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Gaps in our current knowledge are also discussed, so that future endeavors may resolve the relationship between chemical exposures and the impact on pediatric cardiovascular physiology.

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Di (2-ethylhexyl) phthalate induces cardiac disorders in BALB/c mice

Cited by 32 publications

References 46 publications

Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults

Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults

Reducing Toxic Phthalate Exposures in Premature Infants

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

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