DI*A and DI*B Allele Frequencies Among Southern Thai Blood Donors

Abstract

Diego (DI) blood group genotyping is clinically important in Asian populations. Data of Diego blood type among southern Thais is still unknown. This study aimed to report and allele frequencies in southern Thai blood donors and to estimate potential risk of Di incompatibility and alloimmunization in Thai populations. DNA samples obtained from 427 southern Thai blood donors were genotyped for and alleles by polymerase chain reaction with sequence-specific primer. and allele frequencies among southern Thais were 0.0047 and 0.9953. Their frequencies were similar to those among American Native, Italian, Filipino, Alaska Native/Aleut and Hawaiian/Pacific Islander populations; while, the frequencies significantly differed from central and northern Thai, Southeast Asian, Brazilian, Southern Brazilian, Brazilian Japanese descendants, Japanese, Han Chinese, Chinese, and Korean populations ( < 0.05). The Di incompatibility among southern Thais (0.93%) was lower than among central Thais (3.49%), corresponding to a significantly lower probability of Di alloimmunization ( < 0.05). This is the first report of and allele frequencies among southern Thais, which is beneficial for not only creating information for estimating risk of alloimmunization, but also providing antigen-negative red cell donors to prevent both alloimmunization and adverse transfusion reactions.

Determining of JK*A and JK*B Allele Frequency Distribution among Muslim Blood Donors from Southern Thailand

“…Concerning population genetics, JK*A and JK*B alleles could be used as tools to study the relationships among populations. The allele frequencies among Muslims from Southern Thailand were related to those of northern Thais, south and southeast Asians, similar to a related DI*A and DI*B allele frequency study in three populations in Thailand ( 14 ). This may be because the populations are in the same geographic region.…”

“…The populations of the three southern provinces in Thailand—Pattani, Yala and Narathiwat—are almost entirely Muslim. A recent Diego allele frequency study among the southern Thais revealed that the frequencies significantly differed between the central and northern Thais ( 14 ), but the JK allele frequencies among the southern Thai-Muslims remain unknown.…”

HNA‐1, ‐3, ‐4, and ‐5 genotyping using multiplex PCR among southern Thais: Developing continual HNA‐1 null detection

“…They were Thai‐Muslims living in the three southern border provinces of Pattani, Yala, and Narathiwat that have their own specific religion, culture, and lifestyle. Other genetic markers including HLA and Diego blood group alleles among southern Thais demonstrated significant differences from central, northeastern, and northern Thais . For the HNA‐4 and ‐5 systems, ITGAM*01 and ITGAM*02 frequencies among southern Thais were similar to other Thai populations.…”

Red cell genotyping in Thailand: trends for blood transfusion in Asian populations

“…The study reported that allele prevalence in southern Thais differed significantly from those of northern and central and northern Thai populations. As a consequence, Di a incompatibility in southern Thai populations (0Á93%) was lower than found in 2 Thai populations (3Á49%), presenting Di a alloimmunization at a significantly lower possibility [20].…”