Di-n-butyl-and Di-2-ethylhexyl phthalate in human adipose tissue

Mes, Jos; Coffin, D E; Campbell, D. S.

doi:10.1007/bf01685921

Cited by 65 publications

(21 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…39 Urinary phthalates are more likely to represent current as opposed to chronic exposure, although a single sample has moderate sensitivity (56% to 67%) and high specificity (83% to 87%) for MEHP, monobenzylphthalate, mono-ethyl phthalate, and MBP to estimate exposure tertile over a 3-month period. 40 Even if current urinary phthalates are weak indices of exposure, our estimates of association should be biased toward the null for dichotomous outcomes.…”

Section: Discussionmentioning

confidence: 97%

Urinary Phthalates and Increased Insulin Resistance in Adolescents

et al. 2013

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: Phthalate exposure has been associated with insulin resistance in animal studies and crosssectional studies of adults, but has not been studied in adolescents. WHAT THIS STUDY ADDS:We detect associations of urinary phthalate metabolites in a cross-sectional study of US adolescents. The association is highly robust to multiple sensitivity analyses, and specific to phthalates commonly found in food. Further longitudinal study of dietary phthalate exposures is needed. RESULTS:Controlling for demographic and behavioral factors, diet, continuous age, BMI category, and urinary creatinine, for each log (roughly threefold) increase in DEHP metabolites, a 0.27 increase (95% confidence interval 0.14-0.40; P , .001) in HOMA-IR was identified. Compared with the first tertile of DEHP metabolite in the study population (14.5% insulin resistant), the third tertile had 21.6% prevalence (95% confidence interval 17.2%-26.0%; P = .02). Associations persisted despite controlling for bisphenol A, another endocrinedisrupting chemical commonly found in foods, and HOMA-IR and insulin resistance were not significantly associated with metabolites of lower molecular weight phthalates commonly found in cosmetics and other personal care products.CONCLUSIONS: Urinary DEHP concentrations were associated with increased insulin resistance in this cross-sectional study of adolescents. This study cannot rule out the possibility that insulin-resistant children ingest food with higher phthalate content, or that insulin-resistant children excrete more DEHP. Pediatrics 2013;132:e646-e655 AUTHORS:

show abstract

Section: Discussionmentioning

confidence: 97%

Urinary Phthalates and Increased Insulin Resistance in Adolescents

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The widespread use of phthalates and phthalate-containing products in all segments of society has, within the span of a few decades, resulted in global contamination by this class of compounds. The presence of phthalate esters in virtually all ecosystems (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) and in the tissues of man (18)(19)(20)(21)(22), animals (6,7,9,11,16,23,24), and in the food supply of man (24)(25)(26)) is a shocking revelation.…”

Section: Introductionmentioning

confidence: 99%

“…Concern over phthalate toxicity heightened with reports by Marcel and Noel (37,38) and Jaeger and Rubin (39, 40) in 1970 that stored human blood was being contaminated with phthalate ester, namely, di(2-ethylhexyl) phthalate (DEHP), while stored in PVC plastic blood bags. It was subsequently shown that tissues from patients recently transfused and/or exposed to PVC plastic catheters accumulated detectable levels of DEHP in their tissues (18)(19)(20)(21). During the same period (1970)(1971)(1972)(1973)(1974)(1975), a wide variety of biological studies appeared in the literature which further challenged the safety ofthe phthalates (24,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50); these provided evidence that the phthalates could accumulate in mitochondria (24) and that phthalates were teratogenic (41)(42)(43), mutagenic (44), toxic to various types of cultured cells (45)(46)(47), capable of placental transfer (48), capable of altering hepatic ultrastructure (49) and capable of promoting hepatic lipid accumulation under certain conditions (50).…”

Section: Introductionmentioning

confidence: 99%

Effects of phthalate esters on lipid metabolism in various tissues, cells and organelles in mammals.

Bell¹

1982

Environ Health Perspect

View full text Add to dashboard Cite

The effect of phthalate ester plasticizers on a variety of enzyme systems was studied in rats, rabbits and pigs. The feeding of di(2-ethylhexyl) phthalate (DEHP) to animals at levels from 0.1% to 1.0% in the diet resulted in diverse biochemical effects, such as inhibition of cholesterologenesis in liver, testes, and adrenal gland; inhibition of cholesterologenesis in brain and liver of fetal rats from DEHP-fed dams; decreased plasma cholesterol levels; decreased synthesis of hepatic phospholipid and triglyceride; increased fatty acid oxidation in isolated liver mitochondria; and a transient decrease in fatty acid oxidation in isolated heart mitochondria. The addition of DEHP to preparations of rat liver in vitro resulted in inhibition of cholesterologenesis, and its addition to isolated mitochondria from rat heart produced an inhibition of adenine nucleotide translocase. DEHP-feeding to rats and rabbits, however, did not affect platelet function as judged by collagen-and ADP-induced aggregation. The studies presented here indicate that the exposure of animals to phthalate esters can result in a significant perturbation of normal metabolism in liver, heart, testes, adrenal gland and brain and can affect blood lipid levels.

show abstract

“…Di-(2-ethylhexyl)phthalate (DEHP) is the most commonly used plasticizer. Because DEHP does not bind with the plastic, it leaches with time and use from vinyl products, thus becoming a ubiquitous environmental contaminant (Bauer and Herrmann 1997;Bradbury 1996;Giam et al 1978;Griffiths et al 1985;Mayer et al 1972;Mes et al 1974;Øie et al 1997;Sharman et al 1994). In particular, leaching of DEHP from PVC medical devices and deposits in tissue have been well documented (Latini 2000;Tickner et al 2001).…”

mentioning

confidence: 99%

In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy.

Latini

Felice

Presta

et al. 2003

Environ Health Perspect

466

286

View full text Add to dashboard Cite

Phthalate esters are used widely as plasticizers for polyvinylchloride (PVC) formulations in several applications, including medical devices, toys, food wraps, and building products, to impart flexibility to an otherwise rigid PVC. Di-(2-ethylhexyl)phthalate (DEHP) is the most commonly used plasticizer. Because DEHP does not bind with the plastic, it leaches with time and use from vinyl products, thus becoming a ubiquitous environmental contaminant (Bauer and Herrmann 1997;Bradbury 1996;Giam et al. 1978;Griffiths et al. 1985;Mayer et al. 1972;Mes et al. 1974;Øie et al. 1997;Sharman et al. 1994). In particular, leaching of DEHP from PVC medical devices and deposits in tissue have been well documented (Latini 2000;Tickner et al. 2001). Because the DEHP action depends on dose, time, and age (Latini 2000) and because DEHP effects are influenced by the stage of development at exposure among animals (Akingbemi et al. 2001), the DEHP-related exposure risk is potentially higher for the developing fetus and newborn, particularly preterm. Recently, our preliminary findings indicated that the exposure to these environmental contaminants begins during intrauterine life, that these chemicals are able to cross the placental barrier, and that fetal exposure is closely related to maternal exposure (Latini et al. 2003). The aim of this study was to measure concentrations of DEHP and/or its main metabolite, mono-(2-ethylhexyl)phthalate (MEHP), in a larger population of human neonates and to evaluate possible biologic effects from prenatal exposure to DEHP and/or MEHP. Patients and MethodsSubjects. Cord blood samples were collected from 84 consecutive newborns (82 singletons, two twins), born at the general-practice Brindisi Hospital, with the following characteristics: 39 male, 45 female; maternal age at delivery, 29.5 ± 5.1 years (range = 18-42); vaginal delivery, n = 65 (77.4%); gestational age, 38.4 ± 2.2 weeks (range = 27-42); birth weight, 3,220 ± 680 g, (range = 1,150-4,350); 1-min Apgar score, 7.9 ± 0.9; 5-min Apgar score, 8.8 ± 0.5. Eleven of 84 infants were preterm; only three had very low birth weight. Moreover, four infants who were small for gestational age (SGA) were present in our population. None of the examined infants was born after in vitro fertilization pregnancy. The study was approved by the ethics committee of the Brindisi Hospital (Brindisi, Italy), and written informed consent from the parents was obtained. Blood specimens were immediately centrifuged (3,500 × g, 7 min), and serum was stored at -20°C until assay. To avoid any contamination from plasticizers in lab equipment, the serum sample collection, preservation, and treatment were performed only with glass devices. The concentrations of DEHP and MEHP were determined by highperformance liquid chromatography, at the Department of Chemistry of the University of L'Aquila, an institution certified in agreement with the International Organization for Standardization 9001 quality system, as described previously .Data analysis. Data are expressed as mean ± SD...

show abstract

Di-n-butyl-and Di-2-ethylhexyl phthalate in human adipose tissue

Cited by 65 publications

References 3 publications

Urinary Phthalates and Increased Insulin Resistance in Adolescents

Urinary Phthalates and Increased Insulin Resistance in Adolescents

Effects of phthalate esters on lipid metabolism in various tissues, cells and organelles in mammals.

In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy.

Contact Info

Product

Resources

About