2004
DOI: 10.1293/tox.17.177
|View full text |Cite
|
Sign up to set email alerts
|

Di-n-butyl Phthalate is Toxic to the Male Reproductive System and Its Toxicity is Enhanced by Thioacetamide Induced Liver Injury

Abstract: Abstract:The modifying effects of liver injury on male reproductive organ toxicity of di-n-butyl phthalate (DBP) were studied using male F344 rats. Seventy-two male animals, aged 10 weeks at the commencement, were divided into 8 groups of 9 rats each. Groups 1 to 4 were given 200 mg/kg bw of thioacetamide (TAA) intraperitoneally 3 times / week, while Groups 5 to 8 were injected with the PBS vehicle only. From 1 week after the start, groups 1 and 5, 2 and 6, and 3 and 7 were given daily 500, 125, 31.25 mg/kg bw… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
8
1

Year Published

2006
2006
2023
2023

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(9 citation statements)
references
References 25 publications
0
8
1
Order By: Relevance
“…Finally, a decreased sperm count was observed. At this dose, the nonreproductive organs weight did not change, as was observed in the rodents receiving a lower dose [19,21]. When given orally at a dose of 500 mg/kg bw/day, DBP caused subsequent toxic effects in rodents, which are described in detail in Table 1 [15,17,21,24].…”
Section: Reprotoxicity -Testicular Effectsmentioning
confidence: 51%
See 4 more Smart Citations
“…Finally, a decreased sperm count was observed. At this dose, the nonreproductive organs weight did not change, as was observed in the rodents receiving a lower dose [19,21]. When given orally at a dose of 500 mg/kg bw/day, DBP caused subsequent toxic effects in rodents, which are described in detail in Table 1 [15,17,21,24].…”
Section: Reprotoxicity -Testicular Effectsmentioning
confidence: 51%
“…Abnormal sperm count was doubled in the lower dose; however, the rabbits exposed to the higher dose had a decreased sperm count. In the rabbits treated with DBP at a dose of 400 mg/kg bw/day, the epididymal sperm count did not change whereas a lower dose (≥100 mg/kg bw/day) in rodents caused adverse effects on sperm production [15,18,19]. Administering DBP at a dose of 520 mg/kg bw resulted in a decreased progressive and mass sperm motility and live sperm percentage, along with a significant elevation of testicular malondialdehyde, and without changes in other testicular enzymes.…”
Section: Reprotoxicity -Testicular Effectsmentioning
confidence: 99%
See 3 more Smart Citations