Diabetes and Amoebiasis: a high risk encounter

Bredin, Christian; Margery, J.; Bordier, L.; Mayaudon, H.; Dupuy, O.; Vergeau, Bertrand Marie; Bauduceau, B.

doi:10.1016/s1262-3636(07)70095-2

Cited by 8 publications

(6 citation statements)

References 4 publications

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“…Male patients and patients with chronic pulmonary disease or DM have a higher risk of developing severe pneumonia after influenza A infection[ 53 ]. Diabetic patients are at higher risk for severe complications after amoebic infection[ 54 ]. Some pertussis infections may be a risk factor for type 1 DM[ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus

Cui¹,

Wu²,

Lü³

et al. 2022

WJCC

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BACKGROUND A comprehensive literature search shows that Sanqi and Huangjing (SQHJ) can improve diabetes treatment in vivo and in vitro , respectively. However, the combined effects of SQHJ on diabetes mellitus (DM) are still unclear. AIM To explore the potential mechanism of Panax notoginseng (Sanqi in Chinese) and Polygonati Rhizoma (Huangjing in Chinese) for the treatment of DM using network pharmacology. METHODS The active components of SQHJ and targets were predicted and screened by network pharmacology through oral bioavailability and drug-likeness filtration using the Traditional Chinese Medicine Systems Pharmacology Analysis Platform database. The potential targets for the treatment of DM were identified according to the DisGeNET database. A comparative analysis was performed to investigate the overlapping genes between active component targets and DM treatment-related targets. We constructed networks of the active component-target and target pathways of SQHJ using Cytoscape software and then analyzed the gene functions. Using the STRING database to perform an interaction analysis among overlapping genes and a topological analysis, the interactions between potential targets were identified. Gene Ontology (GO) function analyses and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted in DAVID. RESULTS We screened 18 active components from 157 SQHJ components, 187 potential targets for active components and 115 overlapping genes for active components and DM. The network pharmacology analysis revealed that quercetin, beta-sitosterol, baicalein, etc. were the major active components. The mechanism underlying the SQHJ intervention effects in DM may involve nine core targets (TP53, AKT1, CASP3, TNF, interleukin-6, PTGS2, MMP9, JUN, and MAPK1). The screening and enrichment analysis revealed that the treatment of DM using SQHJ primarily involved 16 GO enriched terms and 13 related pathways. CONCLUSION SQHJ treatment for DM targets TP53, AKT1, CASP3, and TNF and participates in pathways in leishmaniasis and cancer.

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Section: Discussionmentioning

confidence: 99%

Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus

Cui¹,

Wu²,

Lü³

et al. 2022

WJCC

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“…[6,8] It occurs in adults after an attack of chronic colitis that can be asymptomatic which sometimes makes its appearance unforeseen. [9] In decreasing order of frequency lesions develop in the caecum, appendix, and rectosigmoid region. Other sites include hepatic flexure, the transverse colon, and splenic flexure.…”

Section: Discussionmentioning

confidence: 99%

Multicentric ameboma of the colon mimicking Crohn℉s disease

Ramachandran

Thomas

Baby

et al. 2015

Journal of Digestive Endoscopy

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Entamoeba histolytica infection can lead to colitis, colonic perforation abscess, and ameboma formation. Amebic colitis is common in developing countries, with its varied and nonspecific symptoms. Amebomas can occur rarely due to the formation of excess granulation tissue which usually occurs in cecum and ascending colon. A 64-year-old lady presented with abdominal pain and mass in the right side of abdomen. Imaging showed multicentric colonic masses. On colonoscopy multiple stricturizing ulcerated lesions involving cecum, ascending, proximal transverse colon, and splenic flexure were seen, which were suggestive of Crohn′s disease or multicentric neoplasm. Histopathological examination revealed multicentric lesion with focal necrosis and trophozoites of E. histolytica. Diagnosis of ameboma was made and antiamoebic treatment was started. She had full resolution of symptoms. We present this case since it is a case of ameboma, a rare complication of amebic colitis with an extremely rare presentation of multiple ulcerated stricturizing lesions, involving cecum, ascending, transverse colon, and splenic flexure which typically resembled Crohn′s disease.

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“…53 When present in T2DM patients, it can induce severe amoebic colitis due to the microangiopathy that occurs in diabetic patients. 54 Microangiopathy caused by T2DM, mainly affects blood vessels in the retinas and kidneys and also compromises small vessels in the intestinal wall, restricting the inflammatory response against amoebic trophozoites, resulting in greater tissue damage. This relationship is supported by studies that found that immunosuppression caused by diabetes was observed in more than 50% of patients with amoebiasis, reinforcing the need for the diagnosis of T2DM in endemic areas to guide therapeutic management in those infected.…”

Section: Metabolic and Parasitic Diseasesmentioning

confidence: 99%

Comorbidities involving parasitic diseases: A look at the benefits and complications

Oliveira

Cruz

Pinheiro

et al. 2022

Exp Biol Med (Maywood)

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Parasitic infections acquired by the population cause substantial morbidity worldwide, with individuals from developing countries being most affected. Some parasites remain in the host for long periods, settling in different organs, manipulating the flow of nutrients and metabolites, and influencing the immune response, favoring their adaptation. The host attempts to counteract the metabolic and immunological alterations and the possible damage caused by infection. These metabolic and immunological changes experienced by the host can influence the progression of other existing morbidities or those that will be acquired in the future. Cancer and metabolic diseases are also frequent causes of morbidity in the world population. The large numbers of individuals affected by cancer and metabolic diseases and the high prevalence of morbidity caused by parasitic diseases favor the development of comorbidity involving these pathologies. This review provides an overview of major advances in research on cancer and metabolic diseases associated with parasitic infections. Information about hosts and parasites such as alterations of the immune response, metabolism and adaptation mechanisms of the parasites, and parasitic molecules with therapeutic potential is provided, as well as the beneficial results or complications related to the comorbidities discussed herein. We emphasize the need to conduct additional studies addressing comorbidities associated with parasitic infections to improve the understanding of the impact of this association on the progression of morbidities, as well as the possibility of the therapeutic use of and therapeutic approaches involving parasites.

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Diabetes and Amoebiasis: a high risk encounter

Cited by 8 publications

References 4 publications

Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus

Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus

Multicentric ameboma of the colon mimicking Crohn℉s disease

Comorbidities involving parasitic diseases: A look at the benefits and complications

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