Diabetes and atherogenesis

Fisher, Miles

doi:10.1136/hrt.2003.018622

Cited by 35 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The diagnosis of the different kinds of cardiomyopathy has been greatly facilitated by the recent developments in non-invasive cardiac imaging [28]. Yet, in type 1 diabetes, the clinical investigation for diabetic cardiomyopathy is not routinely performed [29] largely due to the limits on available technology for optimal screening. Meanwhile the determinants to differentiate this condition from other forms of cardiac muscle pathology are largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Alterations in Diabetic Myocardial Tissue Using High Resolution MRI

Loganathan

Bilgen

Al-Hafez

et al. 2005

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

Cardiovascular complications, including diabetic cardiomyopathy, are the major cause of fatalities in diabetes. Diabetic cardiomyopathy is expressed in part through fibrosis and left ventricular hypertrophy, increasing myocardial stiffness leading to heart failure. In order to search for curative interventions, precise evaluation of the diabetic heart pathology is extremely important. Magnetic resonance imaging (MRI) is ideally suited for the assessment of heart disorders due to its high resolution, three-dimensional properties and dimensional accuracy. In this study streptozotocin injected Sprague-Dawley rats were used as a model of type 1 diabetes to characterize abnormalities in the diabetic left ventricle (LV). High resolution MRI using a 9.4 T horizontal bore scanner was performed on control and 7 weeks diabetic rats. In the diabetic rats as compared to controls, we found increased LV wall volume to body weight ratio, suggestive of LV hypertrophy; increased LV wall mean pixel intensity, and decreased T2 relaxation time, both suggestive of changes in the diabetic tissue properties, perhaps due to presence of fibrosis which was detected through increase in the collagen fractional area. In addition, changes in the LV cavity area were observed and quantified in post-mortem diabetic hearts indicative of stiffer and less resilient LV myocardial tissue with diabetes. Together the data suggest that LV hypertrophy and fibrosis may be a major factor underlying structural and functional abnormalities in the diabetic heart, and MRI is a valuable tool to non-invasively monitor the pathological changes in diabetic cardiomyopathy.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of Alterations in Diabetic Myocardial Tissue Using High Resolution MRI

Loganathan

Bilgen

Al-Hafez

et al. 2005

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

show abstract

“…Type 2 diabetes mellitus often accompanies carbohydrate and lipid abnormalities and hypertension as part of metabolic syndrome,1 2 and patients with metabolic syndrome are more prone to cardiovascular morbidity and mortality 3–6. The combination of diabetes and hypertension produces a more inflammatory and atherogenic environment within the circulatory system 1.…”

Section: Introductionmentioning

confidence: 99%

Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients

Hong

Choi

Ahn

et al. 2011

Heart

View full text Add to dashboard Cite

show abstract

“…THE DIABETIC HEART IS TARGETED by both coronary and noncoronary pathology that eventually result in cardiac failure (2,10). The failure to maintain tissue glucose homeostasis compromises cardiac structure and function in humans and experimental animal models of diabetes mellitus (17,32).…”

mentioning

confidence: 99%

Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses

Loganathan

Bilgen²,

Al-Hafez³

et al. 2007

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

Diabetes and atherogenesis

Cited by 35 publications

References 22 publications

Characterization of Alterations in Diabetic Myocardial Tissue Using High Resolution MRI

Characterization of Alterations in Diabetic Myocardial Tissue Using High Resolution MRI

Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients

Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses

Contact Info

Product

Resources

About