Diabetes and Cancer

Marble, Alexander

doi:10.1056/nejm193408232110801

Cited by 79 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This phenomenon was interpreted as an evidence for the derivation of pancreatic cancer from the stem cells [23,24]. The presence of these endocrine cells within the entire layers of the malignant epithelium and within the lumen of the glands indicates that they are an integral part of the malignant gland as is evidenced by their presence in the invasive portion of cancers [25] and even in their metastases [26]. Consequently, the endocrine cell within the malignant epithelium may serve as a growth promoting source rather than for provision of hormones.…”

Section: Discussionmentioning

confidence: 99%

The patterns of extrainsular endocrine cells in pancreatic cancer

Schmied

Ulrich

Frieß

et al. 2000

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

Abnormal glucose tolerance and frank diabetes mellitus develop in up to 80% of pancreatic cancer patients. Islets within these tumors show a decreased number of beta cells and increased number of alpha cells. The reduced number of beta cells could induce beta cell neogenesis in extrainsular tissue to compensate for the loss of insulin in islets. On the other hand, because the beta cell depletion in pancreatic cancer seems to be the effect of substances released by cancer cells, suppression of extrainsular endocrine cells is expected. We compared the pattern of extrainsular endocrine cells in pancreatic cancer patients with normal pancreas as well as chronic pancreatitis, which is known to be associated with impaired glucose tolerance or frank diabetes. As in the normal tissue, extrainsular endocrine cells were found in chronic pancreatitis and pancreatic cancer. However, in the chronic pancreatitis specimens insulin cells were the predominant cell type, whereas in pancreatic cancer specimens more glucagon than insulin cells were found, although the differences were statistically insignificant. Thus, our results indicate that the alteration of beta cells in pancreatic cancer patients is mainly restricted to the endocrine cells within the islets and that there is no compensatory proliferation of beta cells.

show abstract

Section: Discussionmentioning

confidence: 99%

The patterns of extrainsular endocrine cells in pancreatic cancer

Schmied

Ulrich

Frieß

et al. 2000

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

show abstract

“…In a survey of approximately 10,000 patients with diabetes mellitus treated at the Joslin clinic, 256 cases of cancer were identified. 1 Of these cancers, 13% were of the pancreas, a proportion that is much higher than observed in non-diabetics. This association between diabetes and pancreatic cancer was later confirmed in numerous publications, [2][3][4] among them a large prospective Swedish cohort study which determined alterations of the cancer risk 10 or more years after the diagnosis of diabetes, thereby excluding reverse causality.…”

Section: Introductionmentioning

confidence: 90%

Diabetes and cancer: Epidemiology and potential mechanisms

Joost

2014

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Type 2 diabetes mellitus is an independent risk factor for cancer such as pancreatic, liver, colorectal and breast cancer. In addition, diabetes decreases the risk of prostate cancer. These associations have been found in numerous epidemiological studies, among them several prospective cohorts. However, such studies do not prove causality of the association and cannot exclude inadequate correction for known confounders (e.g. visceral fat) or the influence of unknown confounders. Thus, it is unclear whether the cancer risk is increased by the causes (e.g. the metabolic syndrome), the metabolic consequences (e.g. hyperglycaemia) or the therapy of diabetes; a question which is of major importance for therapeutic guidelines. Identification of the potential mechanisms by which the diabetes or its therapy accelerates or inhibits the development of cancer will help answering the question by providing biological plausibility. This review will summarize the evidence supporting the association of cancer and type 2 diabetes and discuss its potential causes.

show abstract

“…A link between cancer and diabetes mellitus has been suspected for more than 100 y and until the 1920s hyperglycemia was used as a marker in cancer screening (Freund, 1885;Trinkler, 1890;Boas, 1903;Schafer, 1934;Marble, 1934;Ellinger & Landsman, 1944). Type 2 diabetes, a condition resulting from long-term exposure to high insulin levels, has been found to increase significantly colorectal and colon cancer risk by 43 and 49%, respectively, in the cohort of Glycemic index in chronic disease LS Augustin et al women from the Nurses' Health Study (Hu et al, 1999).…”

Section: Colorectal Cancermentioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

View full text Add to dashboard Cite

Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

show abstract

Diabetes and Cancer

Cited by 79 publications

References 0 publications

The patterns of extrainsular endocrine cells in pancreatic cancer

The patterns of extrainsular endocrine cells in pancreatic cancer

Diabetes and cancer: Epidemiology and potential mechanisms

Glycemic index in chronic disease: a review

Contact Info

Product

Resources

About