Diabetes and Cardiovascular Diseases

Kaur, Jasjeet; Singh, Parminder; Sowers, James R.

doi:10.1097/00045391-200211000-00009

Cited by 54 publications

(30 citation statements)

References 45 publications

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“…A profile of glucose and lipid metabolism characterized by increased plasma glucose and insulin levels (insulin resistance syndrome) increases the risk of cardiovascular disease (9). We therefore measured concentrations of glucose and insulin in plasma samples from rats fed the 2-DG and control diets under nonstress and stress conditions.…”

Section: Effects Of Dietary 2-dg Supplementation On Glucose Regulationmentioning

confidence: 99%

“…THE RISK OF CARDIOVASCULAR disease is increased by highcalorie diets, which can lead to obesity and a metabolic syndrome characterized by insulin resistance and hypertension (9,17). Studies of mice, rats, and monkeys have shown that dietary restriction (reduced caloric intake or intermittent fasting) can increase lifespan and suppress pathogenic processes underlying the development of cancers, cardiovascular disease, and neurodegenerative disorders (1,24,33).…”

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confidence: 99%

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Dietary supplementation with 2-deoxy-d-glucose improves cardiovascular and neuroendocrine stress adaptation in rats

Wan

Camandola

Mattson

2004

American Journal of Physiology-Heart and Circulatory Physiology

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Wan, Ruiqian, Simonetta Camandola, and Mark P. Mattson. Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats. Am J Physiol Heart Circ Physiol 287: H1186 -H1193, 2004; 10.1152/ajpheart.00932. 2003.-Dietary restriction and physical exercise can enhance stress resistance and reduce the risk of cardiovascular disease. We investigated the effects of dietary supplementation with 2-deoxy-D-glucose (2-DG), a glucose analog that limits glucose availability at the cellular level, on cardiovascular and neuroendocrine responses to stress in rats. Young adult male Sprague-Dawley rats were implanted with telemetry probes to monitor blood pressure (BP), heart rate, body temperature, and body movements. These variables were measured at designated times during a 6-mo period in rats fed control and 2-DGsupplemented (0.4% 2-DG, fed ad libitum on a schedule of 2 days on the diet and 1 day off the diet) diets during unperturbed conditions and during and after immobilization stress or cold-water swim stress. Rats fed the 2-DG diet exhibited significant reductions in resting BP, attenuated BP responses during stress, and accelerated recovery to baseline after stress. Plasma concentrations of ACTH and corticosterone were elevated under nonstress conditions in rats fed the 2-DG diet and exhibited differential responses to single (enhanced response) and multiple (reduced response) stress sessions compared with rats fed control rat chow ad libitum. The 2-DG diet improved glucose metabolism, as indicated by decreased concentrations of blood glucose and insulin under nonstress conditions, but glucose and insulin responses to stress were maintained. We conclude that improvements in some cardiovascular risk factors and stress adaptation in rats maintained on a 2-DG-supplemented diet are associated with reduced neuroendocrine responses to the stressors. blood pressure; diabetes; glucocorticoids; heart rate; insulin resistance; preconditioning THE RISK OF CARDIOVASCULAR disease is increased by highcalorie diets, which can lead to obesity and a metabolic syndrome characterized by insulin resistance and hypertension (9, 17). Studies of mice, rats, and monkeys have shown that dietary restriction (reduced caloric intake or intermittent fasting) can increase lifespan and suppress pathogenic processes underlying the development of cancers, cardiovascular disease, and neurodegenerative disorders (1, 24, 33). Dietary restriction reduces resting blood pressure (BP) and heart rate (HR) and increases insulin sensitivity (23,29,31,34). The specific cellular and molecular mechanisms by which dietary restriction promotes health and longevity are not well understood but may involve a decrease in oxidative stress and an increase in cellular stress resistance (18,33). It has been proposed that the metabolic stress imposed by dietary restriction may stimulate cells to produce proteins, such as heat shock proteins and growth factors, that increase the resistance of the cells to disease (19). The bene...

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Section: Effects Of Dietary 2-dg Supplementation On Glucose Regulationmentioning

confidence: 99%

mentioning

confidence: 99%

Dietary supplementation with 2-deoxy-d-glucose improves cardiovascular and neuroendocrine stress adaptation in rats

Wan

Camandola

Mattson

2004

American Journal of Physiology-Heart and Circulatory Physiology

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“…Anyhow, the combination of the hypertension and diabetes results in a severe cardiac pathology than is seen with the either disease alone (Yu and Mcneill, 1991). Experimental and clinical assays have demonstrated that these patients were much more sensible to develop a generalized organ damages and stroke and such occurrence decrease the life expectance and/or compromised the life quality as well (Kaur;Regesta, 2002). The present study clearly demonstrated that streptozotocin at doses 40 or 50 mg/Kg was able to provoke a sustained hyperglycemia; however, the time course of blood glucose changes was significantly different: 28 days versus 7 days, respectively after a single injection.…”

Section: Discussionmentioning

confidence: 43%

Biological response of spontaneously hypertensive rats to the streptozotocin administration

Costa

Vianna

2008

Braz. arch. biol. technol.

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“…This leads to cellular apoptosis and aggravated inflammation which promotes atherosclerosis through platelet aggregation, adhesion and plaque formation [10,12]. Therefore, endothelial dysfunction is a major cause of cardiovascular diseases (CVD) such as stroke, myocardial infarction (MI) and peripheral vascular disease (PVD) [13,14].…”

Section: Endothelial Progenitor Cellsmentioning

confidence: 99%

Genetic Modification of Stem Cells in Diabetes and Obesity

Domingues¹,

Kundu²,

Dore³

et al. 2016

Genetic Engineering - An Insight Into the Strategies and Applications

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Genetic modification, or gene transfer, represents a method of treatment for several diseases. It has been used extensively in the context of cardiovascular diseases; however, its role in the context of metabolic diseases, such as diabetes and obesity, has remained largely unexplored. In this chapter, we will review the use of adult stem cells, focusing on endothelial progenitor cells (EPCs) and mesenchymal stromal cells (MSCs), in the context of diabetes. We have highlighted the use of viral vectors, particularly DNA viruses, as a tool for genetic modification to help stem cells survive and resist apoptosis in a hyperglycemic environment. We then discuss genetic modification of EPCs and MSCs to treat complications of diabetes and obesity. Although there are several unanswered questions in the field of metabolic diseases, the future application of gene transfer technology along with genetic modification of stem cells prior to the therapy holds significant therapeutic promise.

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Diabetes and Cardiovascular Diseases

Cited by 54 publications

References 45 publications

Dietary supplementation with 2-deoxy-d-glucose improves cardiovascular and neuroendocrine stress adaptation in rats

Dietary supplementation with 2-deoxy-d-glucose improves cardiovascular and neuroendocrine stress adaptation in rats

Biological response of spontaneously hypertensive rats to the streptozotocin administration

Genetic Modification of Stem Cells in Diabetes and Obesity

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