Diabetes and cognitive outcomes in a nationally representative sample: the National Health and Aging Trends Study

Wennberg, Alexandra; Gottesman, Rebecca F.; Kaufmann, Christopher N.; Albert, Marilyn; Chen-Edinboro, Lenis P.; Rebok, George W.; Kasper, Judith D.; Spira, Adam P.

doi:10.1017/s1041610214001380

Cited by 24 publications

(18 citation statements)

References 28 publications

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“…There are multiple mechanisms that may explain the associations observed between napping and cognitive function. Napping is associated with greater risk for several medical conditions including type‐II diabetes, incident cardiovascular disease, and greater odds of obesity, which are themselves associated with cognitive deficits . However, we adjusted for medical morbidity and still found an association between napping and cognition.…”

Section: Discussionmentioning

confidence: 78%

Napping characteristics and cognitive performance in older adults

Owusu

Wennberg

Holingue

et al. 2018

Int J Geriat Psychiatry

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Objectives: To determine the association of napping intention, frequency, and duration with cognition in a nationally-representative sample of U.S. older adults. Methods: We performed a cross-sectional analysis of community-dwelling Medicare beneficiaries aged ≥65 years from Rounds 3 or 4 (2013–2014) of the National Health and Aging Trends Study (N=2,549). Participants reported past-month napping intention (intentional/unintentional), napping frequency (rarely/never [non-nappers], some days [infrequent nappers], most days/every day [frequent nappers]), and average nap duration (we categorized as ≤30 minutes [short]; 31–60 minutes [moderate]; and >60 minutes [long]). Cognitive outcomes were performance on immediate and delayed word recall tests (IWR and DWR, respectively), the Clock Drawing Test (CDT), and self-rated memory (score: 1[excellent]-5[very poor]). Results: After adjustment for potential confounders, unintentional nappers had poorer immediate word recall test performance than non-nappers (B=−0.23, p<0.01) and intentional nappers (B=−0.26, p<0.01). After further adjustment for daytime sleepiness, frequent nappers reported poorer self-rated memory than non-nappers (B=0.14, p<0.05). Compared to short nappers, long nappers had poorer IWR (B=−0.26, p<0.05) and CDT scores (B=−0.17, p<0.05). Except for the association of nap duration with IWR and CDT, these associations remained after excluding participants with dementia and/or proxy respondents. Among participants undiagnosed with dementia or proxies, moderate-duration naps were associated with better DWR than short naps (B=0.24, p<0.05). Neither napping intentionality nor frequency were associated with CDT performance. Conclusions: Among older adults, distinct aspects of napping are associated with cognitive performance. Prospective research, with objective measures of napping, is needed to elucidate the link between napping and cognitive trajectories.

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Section: Discussionmentioning

confidence: 78%

Napping characteristics and cognitive performance in older adults

Owusu

Wennberg

Holingue

et al. 2018

Int J Geriat Psychiatry

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“…Here, we investigated the association between DM and cognitive test performance and dementia over a five-year period in a large, nationally representative sample of adults 65 years old and older – the National Health and Aging Trends Study (NHATS). Our previous work in NHATS showed that DM was cross-sectionally associated with poorer performance on cognitive tests, but not dementia diagnosis (Wennberg et al, 2014). In this longitudinal study we hypothesized that DM would predict incident dementia diagnosis and decline in cognitive performance over time, above and beyond what might be expected with age.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal association between diabetes and cognitive decline: The National Health and Aging Trends Study

Wennberg

Hagen

Gottesman³

et al. 2017

Archives of Gerontology and Geriatrics

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Type II diabetes mellitus (DM) is associated with increased risk of dementia; however, few studies have examined the longitudinal association between DM and cognitive outcomes in large nationally representative cohorts. We investigated these associations in 7605 participants enrolled in the National Health and Aging Trends Study, a nationally representative prospective study of Medicare beneficiaries ≥65, from 2011 to 2015. Participants or proxy respondents reported DM and dementia diagnosis, and participants completed immediate and delayed recall word list learning tests and the Clock Drawing Test. In multivariable-adjusted generalized linear mixed models, baseline DM diagnosis was associated with decline on immediate and delayed word recall and the Clock Drawing Test. In Cox proportional hazards models, DM also predicted incident dementia in older age groups at baseline. These findings further support the notion that DM is associated with cognitive outcomes, suggesting that treatment and prevention of DM may reduce the risk of these outcomes. However, more studies are needed to better understand whether DM treatments affect this relationship.

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“…However, Wennberg et al 21 reported a similar frequency of this self-rated disease (24%) in a representative sample of American seniors (≥65 years).…”

Section: Discussionmentioning

confidence: 85%

Associations among self-reported diabetes, nutritional status, and socio-demographic variables in community-dwelling older adults

et al. 2014

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ObjectiveThe aim of this study was to describe relationships between self-reported diabetes mellitus and its treatment, according to demographic and socioeconomic data, as well as indicators of nutritional status in community-dwelling older adults. MethodsThis is a population-based and a cross-sectional study derived from the multicentric survey "Frailty in Brazilian Elderly". The random sample consisted of 881 community-dwelling older adults aged 65 years and older from the city of Campinas. The self-reported variables were: age, gender, family income (minimum salaries), education (years of education); and absolute data (yes versus no) regarding unintentional weight loss and weight gain, diabetes, and its treatment. Anthropometric variables were collected by trained examiners following classic protocols. Body mass index was classified as: underweight <23; normal weight ≥23 and <28; overweight ≥28 and <30; and obesity ≥30. Waist-to-hip ratio, indicator of abdominal adiposity, was classified according the metabolic risk, for male and female, respectively: low 0.90-0.95 and 0.80-0.85; moderate 0.96-1.00 and 0.86-0.90; and high >1.00 and >0.90.

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Diabetes and cognitive outcomes in a nationally representative sample: the National Health and Aging Trends Study

Cited by 24 publications

References 28 publications

Napping characteristics and cognitive performance in older adults

Napping characteristics and cognitive performance in older adults

Longitudinal association between diabetes and cognitive decline: The National Health and Aging Trends Study

Associations among self-reported diabetes, nutritional status, and socio-demographic variables in community-dwelling older adults

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