Diabetes and Lung Disease: A Neglected Relationship

Khateeb, Jasmin; Fuchs, Eyal; Khamaisi, Mogher

doi:10.1900/rds.2018.15.e1

Cited by 7 publications

(9 citation statements)

References 130 publications

(166 reference statements)

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“…As periodontal diseases and lung cancer share many common and well-established risk factors, including smoking, alcohol use, and diabetes, 35,37,38 properly adjusted hazard ratios are necessary.…”

Section: Discussionmentioning

confidence: 99%

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Wang

Yang

Zou

et al. 2020

J of Periodontal Research

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Periodontal disease (PD), as a chronic bacterial infection, might cause cardiovascular and some other systemic diseases, with recent studies reporting that it exhibits some connection with lung cancer. While studies have shown that poor oral health might increase the risk of lung cancer, the veracity of these reports is questionable. Therefore, this meta‐analysis was undertaken to investigate the association between PD and the risk of lung cancer. A search was run in PubMed, EMBASE, MEDLINE, CENTRAL, and ClinicalTrials.gov databases up to January 1, 2020. Cohort and case‐control studies investigating the correlation between PD and lung cancer were included. Eligibility assessment and data extraction were conducted independently, and a meta‐analysis was performed to synthesize the data. The association between PD, edentulism, and lung cancer was measured by the adjusted hazard ratios (HRs) or odds ratios (ORs) and their 95% confidence intervals (CIs) provided in articles. We employed appropriate effect model in terms of I2 (a fixed‐effect model for PD and a random‐effect model for edentulism) to obtain summary effect estimates. Statistical heterogeneity was investigated by chi‐square test and I2 statistics. Newcastle‐Ottawa Scale (NOS) was used to assess the quality of their method. Six cohort studies (eight references) and two case‐control studies, assessed as high‐quality, involving 167 256 participants, were included in the review. The summary estimates based on adjusted data showed an association between PD and a significant risk of lung cancer both in cohort studies (HR = 1.40, 95% CI = 1.25‐1.58; I2 = 8.7%) and case‐control studies (OR = 1.51, 95% CI = 1.16‐1.98; I2 = 36.5%). Similar features were found in the sensitivity analysis and subgroups for six cohort studies, of male only (HR = 1.36, 95% CI = 1.15‐2.60), setting the lung cancer incidence as endpoint (HR = 1.39, 95% CI = 1.24‐1.57; I2 = 23.9%), and adjusting alcohol for multifactorial HR (HR = 1.38, 95% CI = 1.21‐1.57; I2 = 39.9%). The summary HR for edentulism was 1.93 (95% CI = 1.05‐3.57; I2 = 55.3%). No obvious publication bias was detected. This systematic review and meta‐analysis demonstrated a significant association between PD and the incidence of lung cancer. Further observational studies are required by using standardized measurements to assess the periodontal status and by eliminating confounding factors, such as alcohol and diabetes, to verify such a relationship.

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Section: Discussionmentioning

confidence: 99%

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Wang

Yang

Zou

et al. 2020

J of Periodontal Research

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“…[ 23 ] In addition, insulin resistance and altered glucose homeostasis in patients with T2DM was associated with over-inflammation. [ 24 ] Thus, poor glycemic control worsens outcomes for patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

The severity and clinical characteristics of COVID-19 among patients with type 2 diabetes mellitus in Jazan, Saudi Arabia

Badedi¹,

Muhajir²,

Alnami³

et al. 2022

Medicine

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Background: The objectives of the current study were to assess the severity and clinical characteristics of coronavirus disease 2019 among Saudi adults with type 2 diabetes mellitus (T2DM) in Jazan region, Saudi Arabia.Methods: This retrospective cohort study included 412 patients with COVID-19 selected randomly from the Health Electronic Surveillance Network system, which contains the primary data on COVID-19 infections in Jazan.Results: COVID-19 disease duration was significantly longer in patients with T2DM (mean = 10.7 days) compared with those without T2DM (mean = 8.3 days) (P = .01). Six (7%) patients experienced an increase in blood glucose concentrations and had to escalate their total daily insulin dose accordingly. Median fasting and random blood glucose levels increased after infection with COVID-19 (pre-COVID median = 119 and 172 mg/dL, respectively; post-COVID median = 148 and 216 mg/dL, respectively) (P = .02). The total insulin dose pre-COVID (median = 42 units/d) increased after infection with COVID-19 (median = 58 units/d) (P = .01). Most patients with T2DM had clinical COVID-19 symptoms (91%) and the remainder (9%) were asymptomatic. A large proportion (80%) of T2DM patients with mild COVID-19 symptoms self-isolated at home. COVID-19 patients with T2DM (11%) who had an oxygen saturation of 90% and admitted to the intensive care unit were higher than those without T2DM (5%) (P = < .001). COVID-19 patients with T2DM (9%) had higher mortality rate than COVID-19 patients without T2DM (1%) (P = < .001).Conclusion: COVID-19 patients with T2DM were associated with a higher risk of admission to the intensive care unit and mortality than COVID-19 patients without T2DM.Abbreviations: A1C = glycated hemoglobin A1C, BMI = body mass index, COVID-19 = coronavirus disease 2019, ICU = intensive care unit, SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2, T2DM = type 2 diabetes mellitus.

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“…Its airway hyperresponsiveness induces bronchoconstriction and chronic inflammation. 2 In one study, researchers identified 11 significant m 6 A regulators associated with asthma from the GSE40888 dataset. 46 Subsequently, five candidate m 6 A regulators were screened according to the nomogram model to predict the risk of childhood asthma.…”

Section: Role Of M 6 a Rna Methylation In Asthmamentioning

confidence: 99%

“…1 Lung diseases include asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH), and lung cancer. 2 COPD is a common chronic disease, which is the fourth leading cause of death in the world, with the characteristics of airflow obstruction. IPF is a kind of chronic progressive fibrosis interstitial pneumonia, which is characterized by dyspnea and gradual deterioration of lung function.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of N6-methyladenosine RNA methylation in lung diseases

Zhou

Yan

et al. 2022

Exp Biol Med (Maywood)

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In recent years, with the increase of air pollution, smoking, aging, and respiratory infection, the incidence rate and mortality of lung diseases are increasing annually, which has become a major hazard to human health. N6-methyladenosine (m6A) RNA methylation is the most abundant modifications in eukaryotes, and such modified RNA can be specifically recognized and combined by m6A recognition proteins and then mediate RNA splicing, maturation, enucleation, degradation, and translation. More and more studies have revealed that the m6A modification is involved in the pathogenesis and development of some diseases; however, the mechanisms of m6A in lung diseases are poorly understood. In this review, we summarize the latest progress in the biological function of m6A modifications in lung diseases and discuss the potential therapeutic and prognostic strategies. The dysregulation of global m6A levels and m6A regulators may affect the occurrence and development of asthma, chronic obstructive pulmonary disease, lung cancer, and other lung diseases through inflammation and immune function. In lung cancer, this modification has an important impact on malignant cell proliferation, migration, invasion, and drug resistance. In addition, abnormally changed m6A-modified proteins in lung cancer tissue samples and circulating tumor cells (CTCs) may be used as diagnostic and prognostic markers of lung cancer. Models composed of multiple m6A regulators can be used to evaluate the risk prediction or prognosis of asthma and pulmonary fibrosis. In general, the in-depth study of m6A modifications is a frontier direction in disease research. It provides novel insights for understanding of the molecular mechanisms underlying disease occurrence, development, and drug resistance, as well as for the development of effective novel therapeutics.

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Diabetes and Lung Disease: A Neglected Relationship

Cited by 7 publications

References 130 publications

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

The severity and clinical characteristics of COVID-19 among patients with type 2 diabetes mellitus in Jazan, Saudi Arabia

Emerging role of N6-methyladenosine RNA methylation in lung diseases

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