Diabetes and male sexual function

Rehman, Khaleeq-Ur; Beshay, Evette; Carrier, Serge

doi:10.4172/1488-5069.1000001

Cited by 21 publications

(17 citation statements)

References 54 publications

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“…43) Diabetes also results reproductive disorders that results male and female infertility. 1,2) The present work confirm the male reproductive disorders in diabetic state as proposed by others 44) along with protective effect of the formulated experimental drug, MTEC for recovery of diabetes and testicular dysfunctions noted in diabetic state. The aqueous-methanol (40 : 60) extract of the above plant parts used here exhibit most effective and performing results than other solvents used for extract preparation which has been noted by trial and error by our labora- tory.…”

Section: Discussionsupporting

confidence: 89%

“…11) The copulatory behavior of diabetic rat has been collapsed 12) along with low fertility in induced normal mating. 12) In human, diabetes is associated with erectile dysfunction 13,14) along with loss of libido 1,5) and abnormal morphology of sperm, low plasma levels of gonadotrophins and testosterone. 15) Though there are several reports about dysfunctions of the male reproductive activity in diabetic state but the data are confusing, and the exact role that insulin plays in the regulation of male reproductive function is still unclear.…”

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confidence: 99%

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Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Mallick

Mandal

Barik

et al. 2007

Biological & Pharmaceutical Bulletin

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Diabetes is associated with declining sexual function in both male 1) and female 2) individuals. In case of female, diabetic symptoms consistent with autonomic neuropathy associated with decreased subjective sexual arousal. 3) In recent study Erol et al. noted that women with type 2 diabetes experienced higher prevalence rates of sexual dysfunction when compared to non diabetic. 4) Approximately 80% of diabetic patients complained loss of libido, 60% had diminished clitoral sensitivity, 50% experienced organic dysfunction, 40% experienced vaginal discomfort, and 40% experienced vaginal dryness. 5) Type 1 diabetic women experienced higher prevalence of reduced vasocongestion and reduced vaginal lubrication to erotic stimuli. 6) Thus these clinical studies suggest that both type 1 and type 2 impede the sexual arousal responses in women.Male reproductive alterations have been widely reported in model animals and human with diabetes. 7) Streptozotocin induced diabetes in male rats resulted atrophy of sex organ, changes in histoarchitecture of ventral prostate, 8) diminution in sperm count, 8) along with low levels in plasma gonadotrophins 9,10) and testosterone. 11) The copulatory behavior of diabetic rat has been collapsed 12) along with low fertility in induced normal mating. 12) In human, diabetes is associated with erectile dysfunction 13,14) along with loss of libido 1,5) and abnormal morphology of sperm, low plasma levels of gonadotrophins and testosterone. 15) Though there are several reports about dysfunctions of the male reproductive activity in diabetic state but the data are confusing, and the exact role that insulin plays in the regulation of male reproductive function is still unclear.In traditional practice, medicinal plants are used in many countries to control diabetes mellitus. The National Centre for Complementary and Alternative Medicine, established in 1998 by the United States Government where development of herbal medicine is one of the important subjects of study. 16,17) Moreover the herbal drug is of first choice at present because plant drugs are to be less toxic and more free from side effect than synthetic one. 18) M. paradisiaca is a tree like herb belonging to the Musaceae family and different parts of the plant have medicinal value. 19,20) T. indica LINN is tree type of plant belonging to the Caesalpiniaceae family was used as a traditional medicine for the management of diabetes mellitus. 21) E. Jambolana is used as traditional medicine for the management of diabetes. 19) This plant is found all over India and belongs to the Myrtaceae family. Jambu bark cure hemorrhages, burning sensation, dysentery, diarrhea, diabetes, excessive thirst, dyspepsia, cough and asthma and is used in preparation of astringent decoction for gargles and washes. 20) Seeds are used for the treatment of diabetes. 20) Coccinia indica is under Cucurbitaceae family and has medicinal importance as observed earlier by others. 22) In our previous work we have reported the antidiabetic effect of some of these plant pa...

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Mallick

Mandal

Barik

et al. 2007

Biological & Pharmaceutical Bulletin

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“…The diabetic condition suppresses reproductive function resulting in male and in female infertility. 44,45) STZ-induced diabetes in male rats results in low sperm counts. 46) This may be due to inhibition in spermatogenesis as reflected in this study by quantification of different generations of germ cells at stage VII of spermatogenic cycle.…”

Section: Discussionmentioning

confidence: 99%

Diabetes-induced Testicular Disorders Vis-a-vis Germ Cell Apoptosis in Albino Rat: Remedial Effect of Hexane Fraction of Root of Musa paradisiaca and Leaf of Coccinia indica

Mallick

Bera

Ali

et al. 2010

JOURNAL OF HEALTH SCIENCE

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The present study was designed to investigate diabetes induced germ cell apoptosis in testis and its protection by treatment with hexane fraction of hydro-methanolic extract of root of Musa paradisiaca and leaf of Coccinia indica in composite manner. Testicular oxidative stress injury was reflected by diminution in the activities of antioxidant enzymes such as catalase, peroxidase, superoxide dismutase and glutathione-s-transferase along with elevation in levels of conjugated diene and thiobarbituric acid reactive substances in diabetic condition. Serum testosterone and insulin levels were decreased in association with elevation in apoptosis of pancreatic islet cells in diabetic rats. Giant cells number along with elevation in the number of apoptotic cells were noted in seminiferous tubules in diabetic model animals. Significant improvements in the levels of blood glucose, serum insulin and testosterone and testicular oxidative stress parameters were noted versus control after treatment of said fraction at a dose of 2 mg (1 : 3)/0.2 ml olive oil per 100 g body weight per day for 45 days to diabetic rats. Numbers of giant cells in seminiferous tubules, apoptotic germ cells and apoptotic pancreatic islet cells were decreased significantly in fraction treated diabetic group versus control. From UV-spectroscopic and TLC studies in connection with phytochemical screening of the said fraction, phenol, flavonoid and alkaloid types of compound were found. From these results it may be concluded that the active ingredient(s) present in hexane fraction of root of Musa paradisiaca and leaf of Coccinia indica have the potential to correct diabetes-induced testicular germ cell apoptosis.

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“…In this review we highlight diabetes-induced alterations in both male and female sexual/reproductive functions. In addition, diabetic men have decreased serum testosterone due to impaired Leydig cell function [16]. In fact, diabetic men are prone to a variety of sexual problems, although it is likely that many of these sexual difficulties are the result of a progressive physical disorder upon which a psychological reaction is superimposed [15].…”

Section: Diabetes and Reproductive Function-a Swift Clinical Overviewmentioning

confidence: 99%

Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species

Amaral¹,

Oliveira²,

Ramalho‐Santos

2008

CDR

284

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Diabetes Mellitus (DM), a state of chronic hyperglycemia, is a major cause of serious micro and macrovascular diseases, affecting, therefore, nearly every system in the body. Growing evidence indicates that oxidative stress is increased in diabetes due to overproduction of reactive oxygen species (ROS) and decreased efficiency of antioxidant defences, a process that starts very early and worsens over the course of the disease. During the development of diabetes, oxidation of lipids, proteins and DNA increase with time. Mitochondrial DNA mutations have also been reported in diabetic tissues, suggesting oxidative stress-related mitochondrial damage. Diabetes-related oxidative stress may also be the trigger for many alterations on sexual function, which can also include decreased testicular mitochondrial function. Although sexual disorders have been extensively studied in diabetic men, possible changes in the sexual function of diabetic women have only recently received attention. The prevalence of sexual dysfunction in diabetic men approaches 50%, whereas in diabetic women it seems to be slightly lower. Testicular dysfunction, impotence, decreased fertility potential and retrograde ejaculations are conditions that have been described in diabetic males. Diabetes is also the most common cause of erectile dysfunction in men. Poor semen quality has also been reported in diabetic men, including decreased sperm motility and concentration, abnormal morphology and increased seminal plasma abnormalities. In addition, diabetic men may have decreased serum testosterone due to impaired Leydig cell function. Among diabetic women neuropathy, vascular impairment and psychological complaints have been implicated in the pathogenesis of decreased libido, low arousability, decreased vaginal lubrication, orgasmic dysfunction, and dyspareunia. An association between the production of excess radical oxygen species and disturbed embryogenesis in diabetic pregnancies has also been suggested. In fact, maternal diabetes during pregnancy is associated with an increased risk of complications in the offspring, such as altered fetal growth, polyhydramnios, fetal loss and congenital malformations. In addition, hypocalemia and reduced bone mineral content are found in neonates of diabetic mothers. Abnormalities in gametogenesis and sexual function have also been documented in animal models for both types of Diabetes, which thus constitute an important research tool to both study the effects of the disease, and to test novel therapeutical interventions. Because sexuality and fertility are important aspects in the lives of individuals and couples, and considering that over 124 million individuals worldwide suffer from Diabetes, this review highlights the impact of Diabetes and associated oxidative stress on sexual function.

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Diabetes and male sexual function

Cited by 21 publications

References 54 publications

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Diabetes-induced Testicular Disorders Vis-a-vis Germ Cell Apoptosis in Albino Rat: Remedial Effect of Hexane Fraction of Root of Musa paradisiaca and Leaf of Coccinia indica

Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species

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