“Diabetes and Metabolism Disorders Medicinal Plants: A Glance at the Past and a Look to the Future 2018”: Antihyperglycemic Activity of Hamelia patens Jacq. Extracts

Abstract

Diabetes is one the world's most widespread diseases, affecting over 327 million people and causing about 300,000 deaths annually. Despite great advances in prevention and therapy, existing treatments for this disorder have serious side effects. Plants used in traditional medicine represent a valuable source in the search for new medicinal compounds. Hamelia patens Jacq. has been used for treating diabetes and, so far, no reports have been made on the in vivo antihyperglycemic activity of this plant. The present study on H. patens aimed to test the antihyperglycemic effect of repeated administrations of the crude and fractional methanolic extracts (CME and FME, respectively) on rats with hyperglycemia induced by streptozotocin. After 10 administrations (20 days), each extract had lowered blood glucose to a normal level. The extracts produced effects similar to metformin. Of the five compounds identified by chromatographic analysis of the extracts, epicatechin and chlorogenic acid demonstrated antihyperglycemic effect. The antioxidant activity of the extracts was evidenced by their IC50 values (51.7 and 50.7 μg/mL, respectively). The LD50≥2000 mg/Kg suggests low toxicity for both CME and FME. Thus, considering that the antihyperglycemic and antioxidant effects of metformin and extracts from H. patens were comparable, the latter may be efficacious for treating diabetes.

Hypoglycemic Activity of Medicinal Plants Used among the Cakchiquels in Guatemala for the Treatment of Type 2 Diabetes

“…For Hamelia a recent study reports the activity of the compounds catechin, quercetin, epicatechin, and chlorogenic acid over type 1 alpha-glucosidases [11]; the authors conclude that the last two compounds contribute to the antihyperglycemic activity of the plant; the results presented here support the hypoglycemic effect of the plant; also we found activity against type 1 enzymes but we did not find activity against type 2 enzymes. For Solanum the alkaloids N-trans-p-coumaroyloctopamine, N-trans-p-feruloyloctopamine, N-trans-p-coumaroyltyramine, and N-trans-p-feruloyltyramine were isolated and the activity correlated with the inhibition of α -glucosidases type 1 [12]; our results support this finding but we did not find activity against type 2 enzymes.…”

“…The inhibition of type 1 alpha-glucosidases and the isolation of (6E,10E,14E,18E)-2,6,10,14,18,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, β -sitosterol, and stigmasterol were done by [10]. The antihyperglycemic effect of the plant associated with the compounds epicatechin and chlorogenic acid was also demonstrated by [11].…”

Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability

“…In accordance with the International Diabetes Federation, 327 million people at present suffer from DM, and this figure will reach 438 million by 2045. Type 2 diabetes is the most abundant form of this disturbance, accounting for 90% of the total affected population [ 12 ]. Diabetes can be managed using a variety of strategies.…”

The Ultrasound-Assisted Extraction of Polyphenols from Mexican Firecracker (Hamelia patens Jacq.): Evaluation of Bioactivities and Identification of Phytochemicals by HPLC-ESI-MS

“…(Rubiaceae) has been reported to possess compounds with important bioactivities, because it has been used in traditional Mexican medicine [3][4][5]. It has been reported to possess several bioactivities in vitro and in vivo, including antihemorrhagic [6], hepatoprotective, antioxidant [7], antihyperglycemic [8], and antibacterial [5] properties, among others. The tested extracts contained phytomolecules such as epicatechin, chlorogenic acid [8], rutin, isoquercetin and soyasaponin Bb, which were first identified in the leaves Molecules 2022, 27, 8845 2 of 15 of the plant [9].…”

“…It has been reported to possess several bioactivities in vitro and in vivo, including antihemorrhagic [6], hepatoprotective, antioxidant [7], antihyperglycemic [8], and antibacterial [5] properties, among others. The tested extracts contained phytomolecules such as epicatechin, chlorogenic acid [8], rutin, isoquercetin and soyasaponin Bb, which were first identified in the leaves Molecules 2022, 27, 8845 2 of 15 of the plant [9]. However, the obtention of bioactive compounds depends mostly on the extraction method and the solvent used.…”