Diabetes and mortality in patients with COVID-19: Are we missing the link?

Sticchi, Alessandro; Cereda, Alberto; Toselli, Marco; Esposito, Antonio; Palmisano, Anna; Vignale, Davide; Nicoletti, Valeria; Leone, Riccardo; Gnasso, Chiara; Monello, Alberto; Khokhar, Arif; Laricchia, Alessandra; Biagi, Andrea; Turchio, Piergiorgio; Petrini, Marcello; Gallone, Guglielmo; Cobelli, Francesco De; Ponticelli, Francesco; Casella, Gianni; Iannopollo, Gianmarco; Nannini, Tommaso; Tacchetti, Carlo; Colombo, Antonio; Giannini, Francesco

doi:10.5152/anatoljcardiol.2021.29132

Cited by 12 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Male patients may express higher ACE2 which is regulated by male sex hormones. 9 The relationship between sex and the incidence of COVID-19 in the DM group is in line with several research results, such as having a much larger male population than female, 14 twice as many male patient subjects as confirmed positive for COVID-198, the presentation of diabetic men at high risk of mortality and the number of hospitalizations is higher in diabetic men than women and in other comorbid diseases. 15 In contrast to a study, in the data there were more female patients than men, although there were more men in the diabetes group than non-diabetics but in both groups had more female patients.…”

Section: Discussionsupporting

confidence: 86%

The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis

2022

View full text Add to dashboard Cite

Background: SARS-CoV-2 first appeared in Wuhan, China, in December 2019. Looking at the prevalence data in the world and in Indonesia, the highest mortality rate due to COVID-19 involves age, gender and comorbidities such as diabetes mellitus. Severity of the condition also refers to coagulation abnormalities, such as abnormal prothrombin time values. Methods: This systematic review study and meta-analysis used online literature sourced from PubMed, Science Direct, EBSCO, Cochrane and Google Scholar. The literature used here is literature that has data on age, sex and prothrombin time of COVID-19 patients with diabetes mellitus whose quality is assessed by the NOS (Newcastle-Ottawa Scale) criteria and processing data using Review Manager 5.4. Results: Out of 8711 literatures that were traced from various search sources, there were 46 literatures that were included in this study. The results of the analysis on age showed the Standardized Mean Difference (SMD) value of 0.45 and P <0.0001 (95% CI: 0.23–0.68), the gender analysis showed an Odds Ratio (OR) value of 3.28 and P = 0.01 (95% CI: 1.26–8.52) and the prothrombin time analysis showed SMD values of 0.41 and P = 0.07 (95%CI = -0.03–0.85). Conclusion: A person who is infected with COVID-19 and has comorbid diabetes mellitus has a high risk of disease severity and mortality if he is older and male.

show abstract

Section: Discussionsupporting

confidence: 86%

The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis

2022

View full text Add to dashboard Cite

show abstract

“…Cardiovascular calcifications are associated with nonphysiological aging and reflect atherosclerotic burden [ 8 , 9 ]. In addition, they are associated with arterial stiffening and are a leading cause of isolated systolic hypertension in the elderly population.…”

Section: Discussionmentioning

confidence: 99%

“…CACS can be easily measured from chest CT performed for pneumonia assessment [ 7 , 9 , 16 – 18 ], and CACS has been demonstrated to be a strong independent predictor of future cardiovascular events [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies found that in COVID-19 patients, despite the presence of comorbidities, coronary calcium and its severity were associated with MACEs (acute coronary syndrome, pulmonary embolism, and stroke) and mortality [ 7 , 9 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that vascular calcification is associated with increased arterial stiffness [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

et al. 2021

Self Cite

View full text Add to dashboard Cite

Cardiac magnetic resonance findings in acute and post‐acute COVID‐19 patients with suspected myocarditis

Palmisano

Vignale

Bruno

et al. 2022

J of Clinical Ultrasound

Self Cite

View full text Add to dashboard Cite

Introduction Cardiac injury is commonly reported in COVID‐19 patients, resulting associated to pre‐existing cardiovascular disease, disease severity, and unfavorable outcome. Aim is to report cardiac magnetic resonance (CMR) findings in patients with myocarditis‐like syndrome during the acute phase of SARS‐CoV‐2 infection (AMCovS) and post‐acute phase (cPACS). Methods Between September 2020 and January 2022, 39 consecutive patients (24 males, 58%) were referred to our department to perform a CMR for the suspicion of myocarditis related to AMCovS ( n = 17) and cPACS ( n = 22) at multimodality evaluation (clinical, laboratory, ECG, and echocardiography). CMR was performed for the assessment of volume, function, edema and fibrosis with standard sequences and mapping techniques. CMR diagnosis and the extension and amount of CMR alterations were recorded. Results Patients with suspected myocarditis in acute and post‐COVID settings were mainly men (10 (59%) and 12 (54.5%), respectively) with older age in AMCovS (58 [48–64]) compared to cPACS (38 [26–53]). Myocarditis was confirmed by CMR in most of cases: 53% of AMCovS and 50% of cPACS with negligible LGE burden (3 [IQR, 1–5] % and 2 [IQR, 1–4] %, respectively). Myocardial infarction was identified in 4/17 (24%) patients with AMCovS. Cardiomyopathies were identified in 12% (3/17) and 27% (6/22) of patients with AMCovS and cPACS, including DCM, HCM and mitral valve prolapse. Conclusions In patients with acute and post‐acute COVID‐19 related suspected myocarditis, CMR improves diagnostic accuracy characterizing ischemic and non‐ischemic injury and unraveling subclinical cardiomyopathies.

show abstract

Diabetes and mortality in patients with COVID-19: Are we missing the link?

Cited by 12 publications

References 8 publications

The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis

The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis

Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry

Cardiac magnetic resonance findings in acute and post‐acute COVID‐19 patients with suspected myocarditis

Contact Info

Product

Resources

About