Diabetes and psychiatric disorders

Balhara, Yatan Pal Singh

doi:10.4103/2230-8210.85579

Cited by 135 publications

(125 citation statements)

References 63 publications

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“…Studies by Islam et al [29] and Saadalla et al [30] independently showed that depression and T2DM are significantly associated. The finding of our study regarding the association of anxiety is also supported by studies conducted by Balhara [8] (P = 0.02), Engum, [7] Almawi et al [31] (P < 0.001), and Afzal et al [32] (OR = 5.348;CI = 2.15-13.29). Stress is also studied as an independent risk factor by various authors like Dutt et al [33] (OR = 4.3;Cl = 2-9.4; P < 0.001), Majgi et al [34] (OR = 10.5; CI = 1.3-90.7, P = 0.03), and Afzal et al [32] (OR = 4.52; CI = 1.95-10.50) and emerged as an independent risk factor for T2DM, which is in concordance with our study.…”

Section: Discussionsupporting

confidence: 79%

Association of depression, stress, and anxiety with type 2 diabetes mellitus: A case-control study

Jayaprasad¹,

Bhatkule²,

Narlawar³

2018

Int J Med Sci Public Health

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Section: Discussionsupporting

confidence: 79%

Association of depression, stress, and anxiety with type 2 diabetes mellitus: A case-control study

Jayaprasad¹,

Bhatkule²,

Narlawar³

2018

Int J Med Sci Public Health

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“…Our study showed stroke was the most common cause of delirium (31%) followed by hyponatraemia (16%). In our study out of 100 patients, 37 were suffering from diabetes mellitus and amongst them most common cause of the delirium was hypoglycaemia (29%) followed by nonhaemorrhagic stroke (18.9%), same as study by Yatin Pal Singh Balhara et al 9 In our study, hyponatraemia was the second commonest cause (16%) and the affected age group was 66 -70 yrs. (37.5%).…”

Section: Discussionsupporting

confidence: 69%

Acute Confusional State in Elderly- Aetiology and Clinical Features

Das¹,

Mohanty²,

Sahu³

et al. 2017

jemds

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BACKGROUNDAcute confusional state is a common manifestation in elderly persons. Because of its multifactorial aetiology, a wide variety of diseases present as acute confusional state in elderly. MATERIALS AND METHODSA descriptive study was conducted in Department of Medicine of SCB Medical College, Cuttack and consecutively 100 adult patients with acute confusional state were included in the study. These patients were studied for the aetiology, clinical features and outcome. Relevant investigations were done in each patient and the data was tabulated. RESULTSAmong 100 patients of acute confusional state, 58 (58%) were male and 42 (42%) were female patients. Most common aetiology was stroke (31%) followed by hyponatraemia (16%) with the predisposing factors being diabetes mellitus (37%) and hypertension (32%) in order. Most common symptom was vomiting (36%) followed by fever (28%). CONCLUSIONAcute confusional state gives physician an alert preceding the illness or events. Early diagnosis and proper management will reduce mortality in elderly. KEYWORDS

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“…This disease is associated with a broad spectrum of complications such as neuropathy, retinopathy, nephropathy, and atherosclerosis [2] . In addition, psychiatric comorbidities such as dementia, depression, and anxiety are experienced by the majority of diabetic patients [3] , resulting in a reduction of quality of life, poor treatment outcomes, and increase in the cost burden of medical care [4] .…”

Section: Introductionmentioning

confidence: 99%

Chronic Administration of Rosa canina Hydro-Alcoholic Extract Attenuates Depressive-Like Behavior and Recognition Memory Impairment in Diabetic Mice: A Possible Role of Oxidative Stress

et al. 2017

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Objective: This study was designed to evaluate whether chronic Rosa canina (RC) extract administration could improve recognition memory and depressive-like behavior in diabetic mice. Materials and Methods: Seventy-five male albino mice (25-30 g) were randomly divided into 5 groups (15 in each group). A single intraperitoneal injection of 200 mg/kg streptozotocin (STZ) was administered to the mice to induce diabetes. The control group received normal saline, and the diabetic groups received normal saline or 50, 250, and 500 mg/kg of RC extract for 28 days. The mice were weighed each week. Recognition memory and depressive-like behavior were assessed using forced swimming and novel object recognition (NOR) tests, respectively. Malondialdehyde (MDA) levels and total antioxidant capacity (TAC) were measured in the mouse brain homogenate to evaluate oxidative stress. Statistical analysis was conducted using SPSS, version 22. Results: The groups receiving 250 or 500 mg/kg RC had significantly lower immobility time (159.4 ± 4.7 and 150.1 ± 3.1 s) compared to the sham control group (192.1 ± 7.8 s) in the forced swimming test, and a higher discrimination index (0.39 ± 0.02 and 0.48 ± 0.03) was seen in diabetic animals in the NOR task compared to the sham control group (0.2 ± 0.01). Also, the groups receiving treatment with RC (250 and 500 mg/kg) had significantly higher TAC (0.92 ± 0.04 and 0.96 ± 0.05 mmol/L) and lower MDA (0.76 ± 0.02 and 0.67 ± 0.03 nmol/mg protein) levels in the brains in comparison to the model group. In the 3rd and 4th weeks of study, the RC-treated mice (250 and 500 mg/kg) gained more weight (31.2 ± 0.3 and 32.4 ± 0.3 g, and 31.3 ± 0.2 and 33.7 ± 0.3 g, respectively) than the diabetic group (30 ± 0.2 and 29.6 ± 0.3 g). Conclusion: This study showed that RC attenuated impairment of recognition memory and depressive-like behavior probably through modulation of oxidative stress in an STZ model of diabetes in mouse brains.

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Diabetes and psychiatric disorders

Cited by 135 publications

References 63 publications

Association of depression, stress, and anxiety with type 2 diabetes mellitus: A case-control study

Association of depression, stress, and anxiety with type 2 diabetes mellitus: A case-control study

Acute Confusional State in Elderly- Aetiology and Clinical Features

Chronic Administration of Rosa canina Hydro-Alcoholic Extract Attenuates Depressive-Like Behavior and Recognition Memory Impairment in Diabetic Mice: A Possible Role of Oxidative Stress

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