Diabetes and seeds: New horizon to promote human nutrition and anti-diabetics compounds in grains by germination

Maleki, Sima; Razavi, Seyed Hadi; Yadav, Hariom

doi:10.1080/10408398.2022.2063793

Cited by 5 publications

(2 citation statements)

References 103 publications

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“…Archaea are indispensable members of the human gut microbiota [19][20][21]. Many archaea thrive in extreme ecosystems, being adapted to acidic, alkaline, saline, or thermophilic conditions [22].…”

Section: Discussionmentioning

confidence: 99%

Alterations in Gut Archaea Composition and Their Bacterial Interactions Linked to Hypertension

Yuan,

Chen,

Liang

et al. 2024

Preprint

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Alterations in the gut microbiota have been linked to hypertension, with the role of archaea, despite being stable constituents, remaining largely unexplored. Shotgun metagenomic analyses of fecal samples were performed on 341 participants from 3 cohorts: discovery cohort (88 individuals), validation cohort 1 (175 individuals), and validation cohort 2 (78 individuals). Principal Coordinates Analysis (PCoA) based on Bray-Curtis distances revealed significant alterations in the composition of enteric archaea between control individuals and hypertensive patients (P < 0.05). Hypertensive groups showed reduced abundances of halophilic archaea (Halorhabdus, Halovivax, and Halorubrum_lipolyticum) and methanogenic archaea (Methanomassiliicoccus and Candidatus_Methanomassiliicoccus_intestinalis). Eleven archaea species, depleted in fecal samples from hypertensive patients, distinguished them from control individuals, with areas under the receiver operating characteristic curve of 0.85, 0.79, and 0.91 in the discovery, validation cohort 1, and validation cohort 2, respectively. Significant correlations were observed between these archaea and clinical data across cohorts. Additionally, a significant positive correlation in richness between gut bacteria and archaea suggests a close cross-kingdom synergy within the microbiome. This study highlights significant shifts in the archaeal populations of hypertensive patients, underscoring the potential of archaeal biomarkers in hypertension diagnosis and suggesting avenues for future therapeutic research.

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Section: Discussionmentioning

confidence: 99%

Alterations in Gut Archaea Composition and Their Bacterial Interactions Linked to Hypertension

Yuan,

Chen,

Liang

et al. 2024

Preprint

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“…In the last decade, recent evidence has demonstrated that another crucial determinant (trigger) of the development of several diseases is the microbial dysfunction, or better the dysbiosis. Dysbiosis has been shown to impact the development and progression of many human diseases, ranging from immune diseases, cardiovascular diseases, neurodegenerative diseases, and cancer [18][19][20][21][22][23]. The very relevant role of microbiota and microbiome (its genome) has led to consider them as the second system of control of the functions of all the organs, tissues of human body after the brain.…”

Section: Microbiome and Allmentioning

confidence: 99%

Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children

Aronica,

Carella,

Balistreri

2024

Preprint

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Alterations in the composition and diversity, metabolism, and products of the microbiome, and of the gut microbiome (GM), have been shown to be closely associated with the onset and progression of many human diseases, including cancer (i.e. hematological neoplasms). Acute lymphoblastic leukemia (ALL) is the most common form of childhood malignancy. Affected cases present typical alterations of GM, followed by inflammation, which contribute to its progression, response to therapy, as well as possible relapses. Recent evidence also reports that GM influences the development and functions of the newborn's hematopoietic system through the process of developmental programming during fetal life, as well as its susceptibility to the onset of onco-hematological pathologies, namely ALL. Furthermore, in children with ALL, GM has been found to vary in composition, variety, and functions during the clinical stages of ALL, and such variation may influence and predict the complications and prognosis of ALL after chemotherapy treatment or stem cell hematopoietic transplant. Here, we suggest some therapeutic strategies, which can be applied at two levels of intervention to recover the microbiome, and consequently prevent/delay ALL or arrest its progression.

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Enhancement of Bone Repair in Diabetic Rats with Metformin‐Modified Silicified Collagen Scaffolds

Wang,

Zhang,

Chen

et al. 2024

Adv Healthcare Materials

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Regenerating bone defects in diabetic rats presents a significant challenge due to the detrimental effects of reactive oxygen species and impaired autophagy on bone healing. To address these issues, a metformin‐modified biomimetic silicified collagen scaffold is developed utilizing the principles of biomimetic silicification. In vitro and in vivo experiments demonstrated that the scaffold enhanced bone tissue regeneration within the diabetic microenvironment through the release of dual bio‐factors. Further analysis reveals a potential therapeutic mechanism whereby these dual bio‐factors synergistically promoted osteogenesis in areas of diabetic bone defects by improving mitochondrial autophagy and maintaining redox balance. The present study provides critical insights into the advancement of tissue engineering strategies aimed at bone regeneration in diabetic patients. The study also sheds light on the underlying biological mechanisms.

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Diabetes and seeds: New horizon to promote human nutrition and anti-diabetics compounds in grains by germination

Cited by 5 publications

References 103 publications

Alterations in Gut Archaea Composition and Their Bacterial Interactions Linked to Hypertension

Alterations in Gut Archaea Composition and Their Bacterial Interactions Linked to Hypertension

Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children

Enhancement of Bone Repair in Diabetic Rats with Metformin‐Modified Silicified Collagen Scaffolds

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