Diabetes and sleep: A complex cause-and-effect relationship

Barone, Mark Thomaz Ugliara; Menna‐Barreto, Luiz

doi:10.1016/j.diabres.2010.07.011

Cited by 173 publications

(145 citation statements)

References 74 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…For some time it has been appreciated that those suffering from metabolic disease, including obesity, impaired glucose tolerance or diabetes also display comorbid sleep difficulties [82]. Most common among these conditions is sleep-disordered breathing, including obstructive sleep apnoea [83].…”

Section: Metabolic Disease and Sleepmentioning

confidence: 99%

Chronomedicine and type 2 diabetes: shining some light on melatonin

et al. 2016

View full text Add to dashboard Cite

In mammals, the circadian timing system drives rhythms of physiology and behaviour, including the daily rhythms of feeding and activity. The timing system coordinates temporal variation in the biochemical landscape with changes in nutrient intake in order to optimise energy balance and maintain metabolic homeostasis. Circadian disruption (e.g. as a result of shift work or jet lag) can disturb this continuity and increase the risk of cardiometabolic disease. Obesity and metabolic disease can also disturb the timing and amplitude of the clock in multiple organ systems, further exacerbating disease progression. As our understanding of the synergy between the timing system and metabolism has grown, an interest has emerged in the development of novel clock-targeting pharmaceuticals or nutraceuticals for the treatment of metabolic dysfunction. Recently, the pineal hormone melatonin has received some attention as a potential chronotherapeutic drug for metabolic disease. Melatonin is well known for its sleep-promoting effects and putative activity as a chronobiotic drug, stimulating coordination of biochemical oscillations through targeting the internal timing system. Melatonin affects the insulin secretory activity of the pancreatic beta cell, hepatic glucose metabolism and insulin sensitivity. Individuals with type 2 diabetes mellitus have lower night-time serum melatonin levels and increased risk of comorbid sleep disturbances compared with healthy individuals. Further, reduced melatonin levels, and mutations and/or genetic polymorphisms of the melatonin receptors are associated with an increased risk of developing type 2 diabetes. Herein we review our understanding of molecular clock control of glucose homeostasis, detail the influence of circadian disruption on glucose metabolism in critical peripheral tissues, explore the contribution of melatonin signalling to the aetiology of type 2 diabetes, and discuss the pros and cons of melatonin chronopharmacotherapy in disease management.

show abstract

Section: Metabolic Disease and Sleepmentioning

confidence: 99%

Chronomedicine and type 2 diabetes: shining some light on melatonin

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Poor sleep quality has been linked to several health problems such as cardiovascular disease (5,6), obesity (7), diabetes (8), depression and anxiety (9)(10)(11), and is a risk factor for mortality (12)(13)(14). Previous research has shown that (chronic) stress is an important antecedent of poor sleep quality and that work can be an important cause of stress (15).…”

mentioning

confidence: 99%

Psychosocial work characteristics and sleep quality: a systematic review of longitudinal and intervention research

Laethem¹,

Beckers²,

Kompier³

et al. 2013

Scand J Work Environ Health

102

100

View full text Add to dashboard Cite

show abstract

“…Cunha, Zanetti and Hass (2008), in one of the scarce studies that assessed sleep in Type 2 Diabetes, analyzed 50 patients, 76% women, 52% married, with ages between 44-79 years, and through the PSQI concluded that the majority (52%) had a poor sleep quality (score ≥5). Likewise, Knutson et al (2006) assessed 161 subjects and Vigg (2003) assessed 220 subjects, both with patients with Type 2 Diabetes, concluded that 71% presented a PSQI score ≥5, showing that Type 2 Diabetes is associated with sleeping problems (Barone & Menna-Barreto, 2011). Rajendran et al (Rajendran, Parthsarathy, Tamilselvan, Seshadri, & Shuaib, 2012) evaluated 120 patients with Type 2 Diabetes (55 women), with a mean age of 53.9 years (SD=9.20) and concluded that the average length of Diabetes diagnosis (7.41±5.90) was positively correlated with the total PSQI score (r=0.181; p<0.050), suggesting that Diabetes duration has a strong influence on patient's sleep (the data was independent of variables as age, gender, body mass index or meds).…”

Section: Discussionmentioning

confidence: 99%

Relationship between socio-demographic, clinical and psychosocial variables in patients with Type 2 Diabetes

Costa

Campos²,

Costa

2013

Análise Psicológica

View full text Add to dashboard Cite

The aim of this study is to analyze the relationship between socio-demographic, clinical and psychosocial variables in patients with Type 2 Diabetes and to establish comparative patterns between genders with this disorder.Patients from a primary care center were assessed through a researcher design form and through the HADS, the ESSS and the PSQI. A total of 90 patients with Type 2 Diabetes were enrolled in this study (50% women), with a mean age of 56.67±6.41 years. The HADS depression presented a score of 3.77±2.98 and 6.70% of the sample revealed depression symptoms. As to anxiety, the HADS presented scores of 7.27±5.07 with 36.60% of the subjects revealing anxiety symptoms. Regarding social support, the results were positive and similar between genders. When it comes to sleep, the sample presented a PSQI of 8.68±2.87, with 73.30% of patients revealing poor sleep quality and 24.40% showing a sleep disorder. When comparing genders, women had higher anxiety (♀ 9.73±5.58; ♂ 4.80±2.91; p=0.000) and depression scores (♀ 4.26±2.69; ♂ 3.26±3.19; p=0.026), and worse sleep quality (♀ 9.88±7.46; ♂ 7.46±2.34; p=0.000).In conclusion, we can state that anxiety symptoms are very prevalent in patients with Type 2 Diabetes and women are more vulnerable to anxiety, depression symptoms and poor sleep quality.

show abstract

Diabetes and sleep: A complex cause-and-effect relationship

Cited by 173 publications

References 74 publications

Chronomedicine and type 2 diabetes: shining some light on melatonin

Chronomedicine and type 2 diabetes: shining some light on melatonin

Psychosocial work characteristics and sleep quality: a systematic review of longitudinal and intervention research

Relationship between socio-demographic, clinical and psychosocial variables in patients with Type 2 Diabetes

Contact Info

Product

Resources

About