Diabetes and Technology for Increased Activity Study: The Effects of Exercise and Technology on Heart Rate Variability and Metabolic Syndrome Risk Factors

Stuckey, Melanie I.; Kiviniemi, Antti M.; Petrella, Robert J.

doi:10.3389/fendo.2013.00121

Cited by 27 publications

(28 citation statements)

References 42 publications

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“…11 Chronic pain and an increase in sympathetic tone have been proposed as the main factors causing hypertension in hypertensive, chronically laminitic horses 14. The release of Equine potent vasoconstrictive factors such as serotonin and endothelin-1 has been demonstrated in horses with laminitis, 8 and the role of insulin as an important mediator in the orchestration of vasoactive proteins, the association of insulin dysregulation with endothelial dysfunction, and a potential increase in peripheral vascular resistance have been proposed. Caloric restriction suppresses sympathetic tone in rodents, 40,41 and exercise 42 and diet 43 improve autonomic balance in humans. Caloric restriction suppresses sympathetic tone in rodents, 40,41 and exercise 42 and diet 43 improve autonomic balance in humans.…”

Section: Discussionmentioning

confidence: 99%

“…35,36,[40][41][42][43] Effort was made to exclude ponies with severe or recently developed laminitis, but nevertheless, the severity of the laminitis and presence of previous or current signs of pain could have affected the results independently of the effects of EMS. This and the aforementioned management and housing conditions could Equine have affected progression of the EMS and many of the measured variables.…”

Section: Discussionmentioning

confidence: 99%

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Cardiovascular findings in ponies with equine metabolic syndrome

Heliczer¹,

Gerber²,

Bruckmaier³

et al. 2017

javma

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OBJECTIVE To determine whether hypertension, high sympathetic tone, resting and exercising arrhythmias, and echocardiographic changes consistent with hypertensive cardiomyopathy were associated with equine metabolic syndrome (EMS) in ponies. DESIGN Prospective case-control study. ANIMALS 19 privately owned ponies with a diagnosis of EMS (history of laminitis, body condition score ≥ 7/9, cresty neck score ≥ 3/5, and abnormal oral sugar test result; cases) and 20 healthy control ponies. PROCEDURES Heart rate (HR), noninvasively measured arterial blood pressure (BP), markers of autonomic tone (splenic volume and HR variability), 24-hour and exercising ECGs, and echocardiograms were compared between cases and controls. RESULTS Compared with controls, cases had a higher mean ± SD HR (44.5 ± 7.5 beats/min vs 38.6 ± 6.8 beats/min) and median mean left ventricular wall thickness (2.0 cm vs 1.8 cm). No differences were identified between groups in BP, splenic volume, HR variability, and number of premature complexes in ECGs. Mean wall thickness was correlated with BP (r = 0.54), high-frequency power (r = -0.71), and ratio of low-to high-frequency power (ϕ = 0.66). Relative wall thickness was correlated with serum insulin concentration (r = 0.71). CONCLUSIONS AND CLINICAL RELEVANCE Ponies with EMS had myocardial hypertrophy that was correlated with insulin response to an oral sugar test, sympathetic and parasympathetic tone, and BP. The heterogeneity and limited sample size of this preliminary study should be considered when drawing conclusions. Cardiovascular changes associated with this syndrome deserve further attention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cardiovascular findings in ponies with equine metabolic syndrome

Heliczer¹,

Gerber²,

Bruckmaier³

et al. 2017

javma

View full text Add to dashboard Cite

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“…In the Diabetes Prevention Program, lifestyle intervention in persons with IFG or IGT resulted in a decrease in heart rate and increase in HRV over 4 years [46]. An 8 week exercise intervention was associated with improvement in the components of the metabolic syndrome and HRV variables [47].…”

Section: Discussionmentioning

confidence: 99%

Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey

Ziegler

Voss

Rathmann³

et al. 2015

Diabetologia

102

107

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Aims/hypothesis Cardiac autonomic nervous dysfunction (CAND) raises the risk of mortality, but the glycaemic threshold at which it develops is unclear. We aimed to determine the prevalence of, risk factors for and impact of CAND in glucose intolerance and diabetes. Methods Among 1,332 eligible participants aged 55-74 years in the population-based cross-sectional KORA S4 study, 130 had known diabetes mellitus (k-DM), and the remaining 1,202 underwent an OGTT. Heart rate variability (HRV) and QT variability were computed from supine 5 min ECGs. Results In all, 565 individuals had normal glucose tolerance (NGT), 336 had isolated impaired fasting glucose (i-IFG), 72 had isolated impaired glucose tolerance (i-IGT), 151 had combined IFG-IGT (IFG-IGT) and 78 had newly detected diabetes mellitus (n-DM). Adjusted normal HRV limits were defined in the NGT population (5th and 95th percentiles). Three HRV measures were more frequently abnormal in those with k-DM, n-DM, IFG-IGT and i-IFG than in those with NGT (p<0.05). The rates of CAND (≥2 of 4 HRV indices abnormal) were: NGT, 4.5%; i-IFG, 8.1%; i-IGT, 5.9%; IFG-IGT, 11.4%; n-DM, 11.7%; and k-DM, 17.5% (p<0.05 vs NGT, except for i-IGT). Reduced HRV was associated with cardiovascular risk factors used to construct a simple screening score for CAND. Mortality was higher in participants with reduced HRV (p<0.05 vs normal HRV). Conclusions/interpretation In the general population aged 55-74 years, the prevalence of CAND is increased not only in individuals with diabetes, but also in those with IFG-IGT and, to a lesser degree, in those with i-IFG. It is associated with mortality and modifiable cardiovascular risk factors which may be used to screen for diminished HRV in clinical practice.

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“…Endurance exercise training reduced waist circumference, lowered systolic blood pressure and diastolic blood pressure and increased high density lipoprotein cholesterol. 31 Additionally, lifestyle interventions have also shown to improve autonomic [32][33][34][35] and vascular function as well. 36,37 Importantly, improvements in heart rate variability with lifestyle interventions were associated with lower risk of diabetes, independent of weight loss and physical activity.…”

Section: Discussionmentioning

confidence: 99%

The effect of active occupational stress management on psychosocial and physiological wellbeing: a pilot study

Jukić

Ihan²,

Strojnik

et al. 2020

Preprint

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Background: The aim of the study was to address the working population with an occupational stress prevention program using mHealth solution and encourage them for healthy lifestyle choices.Methods: Sixteen participants were randomized from the corporate setting. A 24alife app with a good compliance program was selected. Test battery has been designed to test the physical readiness, psychological evaluation and biological blood markers for stress. Participants were followed up after 30, 60 and 90 days, respectively, within the intervention period. Weight of participants was tracked three times per month. Univariate analysis compared the continuous variables by One-Way Repeated-Measures ANOVA test when the data were normally distributed, or Wilcoxon rank sum test for abnormal distribution of variables.Results: Participants used the app with a compliance rate of 94.1%. The psychological evaluation revealed higher motivation for work, lower burnout scores and participants gave subjective responses of better general wellbeing. Some of the participants lost up to four kg of body mass. Physical readiness has also improved.Conclusions: Results of mHealth projects on corporate could include primary health care institutions and health ministry to extend the existing system to patients’ pockets where they can monitor their disease and increase the ability of self-care.

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Diabetes and Technology for Increased Activity Study: The Effects of Exercise and Technology on Heart Rate Variability and Metabolic Syndrome Risk Factors

Cited by 27 publications

References 42 publications

Cardiovascular findings in ponies with equine metabolic syndrome

Cardiovascular findings in ponies with equine metabolic syndrome

Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey

The effect of active occupational stress management on psychosocial and physiological wellbeing: a pilot study

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