Diabetes associates with mortality in critically ill patients with SARS-CoV-2 pneumonia: No diabetes paradox in COVID-19

Bellaver, Priscila; Schneider, Larissa; Schaeffer, Ariell Freires; Henrique, Lílian Rodrigues; Camargo, Joíza Lins; Gerchman, Fernando; Leitão, Cristiane Bauermann; Rech, Tatiana Helena

doi:10.1016/j.heliyon.2023.e18554

Cited by 1 publication

(2 citation statements)

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“…There exists a bidirectional relationship between diabetes and COVID‐19. Research on 187 patients found a significant correlation between hyperglycemia and higher fatality rates among critically sick individuals diagnosed with COVID‐19 35 . According to another study, the prevalence of newly diagnosed diabetes and hyperglycemia in individuals with COVID‐19 was 5%, indicating a 1.75‐fold increase compared to those without COVID‐19 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Research on 187 patients found a significant correlation between hyperglycemia and higher fatality rates among critically sick individuals diagnosed with COVID-19. 35 According to another study, the prevalence of newly diagnosed diabetes and hyperglycemia in individuals with COVID-19 was 5%, indicating a 1.75-fold increase compared to those without COVID-19. 36 In addition to observational research, the findings of bidirectional MR analysis conducted by Cao et al 18 indicate a potential exacerbation of COVID-19 severity by type 2 diabetes (T2D).…”

Section: Potential Confounding Factors and Mechanismsmentioning

confidence: 96%

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Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Ge,

Luo,

Liu

et al. 2023

Journal of Medical Virology

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The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID‐19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID‐19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID‐19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID‐19 and CP. A direct causal relationship between genetically predicted COVID‐19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID‐19 as a definitive cause of pancreatitis.

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Section: Discussionmentioning

confidence: 99%