Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

Siddiqui, Fahad Javaid; Assam, Pryseley Nkouibert; Souza, Nurun Nisa de; Sultana, Rehena; Dalan, Rinkoo; Chan, Edwin

doi:10.1177/2156587217753004

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…Glucose is the primary stimulator of insulin release from pancreatic β-cells, but other inputs contribute to the regulation of insulin secretion, including acetate. Acetate and vinegar have attracted attention in recent years as agents that can counteract several effects of diabetes and associated obesity and insulin resistance ( Petsiou et al, 2014 ; Siddiqui et al, 2018 ). Ketone bodies and acetate levels are increased in diabetes due to increased fatty acid oxidation and ketogenesis caused by lack of insulin or insulin resistance.…”

Section: Acetate and Healthmentioning

confidence: 99%

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

et al. 2020

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Acetate, the shortest chain fatty acid, has been implicated in providing health benefits whether it is derived from the diet or is generated from microbial fermentation of fiber in the gut. These health benefits range widely from improved cardiac function to enhanced red blood cell generation and memory formation. Understanding how acetate could influence so many disparate biological functions is now an area of intensive research. Protein acetylation is one of the most common post-translational modifications and increased systemic acetate strongly drives protein acetylation. By virtue of acetylation impacting the activity of virtually every class of protein, acetate driven alterations in signaling and gene transcription have been associated with several common human diseases, including cancer. In part 2 of this review, we will focus on some of the roles that acetate plays in health and human disease. The acetate-activating enzyme acyl-CoA short-chain synthetase family member 2 (ACSS2) will be a major part of that focus due to its role in targeted protein acetylation reactions that can regulate central metabolism and stress responses. ACSS2 is the only known enzyme that can recycle acetate derived from deacetylation reactions in the cytoplasm and nucleus of cells, including both protein and metabolite deacetylation reactions. As such, ACSS2 can recycle acetate derived from histone deacetylase reactions as well as protein deacetylation reactions mediated by sirtuins, among many others. Notably, ACSS2 can activate acetate released from acetylated metabolites including N-acetylaspartate (NAA), the most concentrated acetylated metabolite in the human brain. NAA has been associated with the metabolic reprograming of cancer cells, where ACSS2 also plays a role. Here, we discuss the context-specific roles that acetate can play in health and disease.

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Section: Acetate and Healthmentioning

confidence: 99%

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

et al. 2020

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“…Vinegar is the product of acetic acid and is reported to have anti-glycemic effects in either animal or human studies (Johnston and Gaas, 2006). The mechanisms of vinegar are based on improved insulin sensitivity and delayed gastric emptying accompanied with improved glycemic control and reduced body weight (Halima et al, 2017;Khezri et al, 2018;Siddiqui et al, 2018;Shishehbor et al, 2017;Chen et al, 2016;Petsiou et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…In a review study, there is a -0.39% (95% CI -0.18 to -0.59%) reduction in mean HbA1c level after 8 to 12 weeks of vinegar administration. However, the long-term outcomes of vinegar were not statistical significance (Siddiqui et al, 2018).…”

Section: Introductionmentioning

confidence: 88%

Effect of black vinegar intake on anthropometric measures, cardiometabolic profiles, and insulin sensitivity among impaired fasting glucose subjects

Chu¹,

Lee²,

Shieh³

et al. 2020

Int Res J Med Med Sci

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This open-label non-controlled study is to evaluate the effects of black vinegar intake for 8 weeks on the anthropometric measures, cardiometabolic profiles, and insulin sensitivity among impaired fasting glucose adults. 32 subjects (14 males and 18 females) were recruited with the mean age of 56.3 (from 25 to 65). Black vinegar 50 ml was diluted to 500 ml with drinking water and was given to all subjects for 8 weeks. At baseline and 8-week, all study subjects received 75 g of oral glucose tolerance test (OGTT) after 10 h of fasting. Venous blood was collected at 0, 30, 60, 90 and 120 min. Plasma glucose and insulin levels were measured using the glucose oxidase method and radioimmunoassay method. Anthropometric variables, blood pressure and blood lipid profiles were measured using standard methods. The Wilcoxon signed-rank test was used to compare the difference between baseline and after eight weeks. After eight weeks, the body weight and BMI decreased from 68.2 ± 14.4 kg to 67.6 ± 14.2 kg and 26.3 ± 4.5 kg/m2 to 26.0 ± 4.4 kg/m2, respectively, with statistical significance (p < 0.05). Triglyceride level decreased from 152.5 ± 134.7 to 140.6 ± 93.8 mg/dl but without statistical significance. The blood glucose levels at 120 min of OGTT decreased from 178.8 ± 57.0 to 173.7 ± 57.5 mg/dl and the insulin levels at 120 min of OGTT increased from 117.5 ± 74.2 to 126.4 ± 95.9 IU/L but not statistically significant (p > 0.05). There is a slight decrease of body weight and BMI, but no significantly change in blood pressure, lipid profiles, and insulin sensitivity after eight weeks of black vinegar intake among impaired fasting glucose adults. However, further large-scale and longer studies are needed to explore the effects of black vinegar on cardiometabolic profiles and insulin sensitivity. Keywords: Black vinegar, anthropometric measures, lipid profiles, insulin sensitivity, impaired fasting glucose.

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“…Apple cider vinegar is a rich source of polyphenols and acetic acid [195]. A systematic review and metanalysis of human trials failed to reach conclusive results on short and long-term blood glucose control after the administration of a wide range of dosages of apple cider vinegar [196]. At present, studies about the effects of apple cider vinegar on human energy expenditure are lacking.…”

Section: Apple Cider Vinegarmentioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

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Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

Cited by 14 publications

References 35 publications

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

Effect of black vinegar intake on anthropometric measures, cardiometabolic profiles, and insulin sensitivity among impaired fasting glucose subjects

A Critical Review on the Role of Food and Nutrition in the Energy Balance

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