Diabetes, Depression, and Cognition: a Recursive Cycle of Cognitive Dysfunction and Glycemic Dysregulation

Black, Sheila; Kraemer, Kyle R; Shah, Avani; Simpson, Gaynell M.; Scogin, Forrest; Smith, Annie

doi:10.1007/s11892-018-1079-0

Cited by 29 publications

(24 citation statements)

References 84 publications

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“…Scientific evidence has shown, both in animal models and in humans, a close correlation between diabetes mellitus [type 1 (T1DM) and type 2 (T2DM)] and cognitive decline leading to dementia; although T2DM has shown a stronger association with brain disorders ( Monette et al, 2014 ; Zilliox et al, 2016 ; Black et al, 2018 ). Among the components of MetS, hyperglycemia has the strongest association with the risk of developing cognitive deterioration ( Šmahelová, 2017 ).…”

Section: From Metabolic Syndrome To Neurological Diseasesmentioning

confidence: 99%

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Maiuolo

Gliozzi

Musolino

et al. 2021

Front. Cell Dev. Biol.

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Metabolic syndrome is not a single pathology, but a constellation of cardiovascular disease risk factors including: central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. The global incidence of Metabolic syndrome is estimated to be about one quarter of the world population; for this reason, it would be desirable to better understand the underlying mechanisms involved in order to develop treatments that can reduce or eliminate the damage caused. The effects of Metabolic syndrome are multiple and wide ranging; some of which have an impact on the central nervous system and cause neurological and neurodegenerative diseases. Autophagy is a catabolic intracellular process, essential for the recycling of cytoplasmic materials and for the degradation of damaged cellular organelle. Therefore, autophagy is primarily a cytoprotective mechanism; even if excessive cellular degradation can be detrimental. To date, it is known that systemic autophagic insufficiency is able to cause metabolic balance deterioration and facilitate the onset of metabolic syndrome. This review aims to highlight the current state of knowledge regarding the connection between metabolic syndrome and the onset of several neurological diseases related to it. Furthermore, since autophagy has been found to be of particular importance in metabolic disorders, the probable involvement of this degradative process is assumed to be responsible for the attenuation of neurological disorders resulting from metabolic syndrome.

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Section: From Metabolic Syndrome To Neurological Diseasesmentioning

confidence: 99%

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Maiuolo

Gliozzi

Musolino

et al. 2021

Front. Cell Dev. Biol.

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show abstract

“…Type 2 diabetes (T2DM) is one of the most common chronic diseases which can damage any organ in the body [1]. Recent studies have shown that the elderly with T2DM are at increased risk for developing micro-and macrovascular complications, as well as some psychiatric disorders such as cognitive dysfunction and dementia [2,3]. Mild cognitive impairment (MCI) is a transition stage between normal aging and dementia.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment

Górska-Ciebiada¹,

Ciebiada²

2019

J Pre Clin Clin Res.

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Gorska-Ciebiada M, Ciebiada M. Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment.Abstract Introduction and objective. Recently, data has indicated a higher incidence of mild cognitive impairment (MCI) in patients with diabetes. Old age is a risk factor for cognitive deterioration and dementia. The aim of the study was to find the factors associated with poor glycaemic control in type 2 diabetic elderly patients with MCI. Materials and method. A cross-sectional study was conducted on 87 diabetic patients with MCI in an outpatient clinic. All subjects were screened for MCI using the Montreal Cognitive Assessment (MoCA). Detailed medical history and collection of blood test samples were performed. Results. 83.9% of participants had poor glycaemic control. A positive correlation was found between HbA1c level and number of visit to a doctor per year, number of co-morbidities, duration of T2DM, triglycerides and fasting glucose level; and a negative correlation between HbA1c level and years of education, HDL cholesterol level and MoCA score. The univariate logistic regression models revealed factors which are associated with poor glycemic control are: less years of education, higher no of visit to doctor per year, increased number of co-morbidities, presence of CVD, retinopathy, higher levels of triglycerides and fasting glucose, lower level of HDL cholesterol, lower MoCA score. Multivariable model revealed that higher plasma levels of fasting glucose and triglycerides are significant predictors. Conclusions. There is a high prevalence of poor glycemic control patients among elderly diabetics with MCI. Higher plasma levels of fasting glucose and triglycerides seems to be the most important predictors of poor glycemic control, however father larger studies are needed to elucidate these relationships.

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“…The prevalence of clinically relevant depression in people with diabetes is 31%, and one in four patients with type 1 or type 2 diabetes are affected by elevated depressive symptoms (Anderson, Freedland, Clouse, & Lustman, 2001). A number of studies have shown that depression is associated with poorer self‐management and medication regimen adherence, functional impairment, unsatisfactory quality of life (QoL), and higher healthcare costs (Black et al, 2018; Ciechanowski, Katon, & Russo, 2000; de Ornelas Maia et al, 2013). Identification and effective management of comorbid depression is increasingly considered an essential component of high‐quality medical care in diabetes, as the ADA (2020) has recommended.…”

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confidence: 99%

Effects of Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy in People With Diabetes: A Systematic Review and Meta‐Analysis

2020

J of Nursing Scholarship

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Purpose The purpose of this study was to determine the effectiveness of mindfulness‐based stress reduction (MBSR) and mindfulness‐based cognitive therapy (MBCT) on depression, quality of life (QoL), and glycosylated hemoglobin (HbA1c) in people with diabetes. Design A systematic literature review and meta‐analysis was conducted. Methods Eight databases (PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature [CINAHL], Cochrane, PsycINFO, and three Chinese databases) were searched for relevant studies from inception to December 2019. Only randomized controlled trials (RCTs) of MBSR and MBCT interventions for people with type 1 and type 2 diabetes were included. Findings Nine studies described in 11 articles were included in the review. Meta‐analysis showed a significant effect favoring MBSR and MBCT on depression (standardized mean difference ‐0.84; 95% confidence interval [CI] ‐1.16 to ‐0.51; p < .0001), the mental health composite score of QoL (mean difference [MD] 7.06; 95% CI 5.09 to 9.03; p < .00001), and HbA1c (MD ‐0.28; 95% CI ‐0.47 to ‐0.09; p = .004). However, effects on the physical health composite score of QoL have not been found. Conclusions MBSR and MBCT are beneficial in improving depression, the mental health composite score of QoL, and HbA1c in people with diabetes. More well‐designed trials using longer follow‐up measurements are needed. Clinical Relevance MBSR and MBCT could be considered as effective complementary treatment alternatives for people with diabetes.

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Diabetes, Depression, and Cognition: a Recursive Cycle of Cognitive Dysfunction and Glycemic Dysregulation

Cited by 29 publications

References 84 publications

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment

Effects of Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy in People With Diabetes: A Systematic Review and Meta‐Analysis

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