Diabetes in B-cell depleted NOD mice

Unique role of CD4+CD62L+regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice

“…NOD diabetogenic T cells to transfer disease. We previously reported in extensive studies that diabetes can be induced, after transfer of polyclonal diabetogenic T cells recovered from the spleen of diabetic NOD mice, into immunodeficient NOD mice (i.e., sublethally irradiated, SCID, or neonates) (15,26,27). The transfer required the concomitant presence of CD4 ϩ and CD8 ϩ T cells.…”

Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules.

“…First, not only CD4-positive but also CD8-positive T cells are present in the islet infiltrates. Second, both CD4-positive and CD8-positive T cells are required for the induction of diabetes in transfer experiments (23,24), and the development of cyclophosphamide-induced diabetes can be prevented by anti-CD8 antibody (25). Similarly, the anti-H-2Kd antibody can prevent spontaneous and cyclophosphamide-induced diabetes (26).…”

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

“…Disease transfer studies in both BB rats (7) and NOD mice (8) or NOD F1 mice (9), in which injections of spleen cells from diabetic animals have induced diabetes in nondiabetic recipients, have further implicated a role for T cells in the disease process. More recent reports have shown that both CD4-and CD8-positive T cells are required for transfer of the disease (10,11).…”