Diabetes in Non-Hispanic White Youth

Bell, Ronny A.; Mayer‐Davis, Elizabeth J.; Beyer, J.; D’Agostino, Ralph B.; Lawrence, Jean M.; Linder, Barbara; Liu, Lenna L.; Marcovina, Santica M.; Rodríguez, Beatriz L.; Williams, Desmond E.; Dabelea, Dana

doi:10.2337/dc09-s202

Cited by 194 publications

(160 citation statements)

References 47 publications

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“…Our results agree with the SEARCH for Diabetes in Youth Study reporting obesity in 80%, hypertension in one-quarter, and elevated LDL cholesterol in one-half of young affected people in the U.S. (25). The early development of cardiometabolic risk factors is further highlighted in the recently published TODAY (Treat Type 2 Diabetes Early and Aggressively in Young) trial of adolescents with newly diagnosed type 2 diabetes (26,27).…”

Section: Metabolic Controlsupporting

confidence: 90%

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

et al. 2013

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OBJECTIVEWe examined metabolic profiles and cardiovascular-renal outcomes in a prospective cohort of Chinese patients with young-onset diabetes defined by diagnosis age ,40 years. Patients with type 1 diabetes and normal-weight (BMI ,23 kg/m 2 ) and overweight (BMI ‡23 kg/m 2 ) patients with type 2 diabetes were compared. RESEARCH DESIGN AND METHODSBetween 1995 and 2004, 2,323 patients (type 1 diabetes, n = 209; normal-weight type 2 diabetes, n = 636; and overweight type 2 diabetes, n = 1,478) underwent detailed clinical assessment. Incident cardiovascular disease (CVD) including coronary heart disease, stroke, and peripheral vascular disease were identified using hospital discharge diagnoses. End-stage renal disease (ESRD) was defined by glomerular filtration rate ,15 mL/min/1.73 m 2 or dialysis. RESULTSOverweight patients with type 2 diabetes had the worst metabolic profile and highest prevalence of microvascular complications. Over a median follow-up of 9.3 years, incidences of CVD were 0.6, 5.1, and 9.6 per 1,000 person-years in patients with type 1 diabetes, normal-weight patients with type 2 diabetes, and overweight patients with type 2 diabetes. A slide set summarizing this article is available online.

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Section: Metabolic Controlsupporting

confidence: 90%

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

et al. 2013

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“…The number of children in the populations in which type 2 diabetes was detected ranged from 1,647 [18] to several millions [11][12][13][19][20][21][22][23][24][25] and covered different age categories. The 37 included studies described data about many different ethnicities-Japanese, Taiwanese, multi-ethnic, New Zealand-Maori, New Zealand-European, Turkish, South Asian, Black, Aboriginal, African-American, American Indian, Pima Indian, Ojibwa-Cree, non-Hispanic whites, Hispanic, etc.…”

Section: Study Population and Ethnicitiesmentioning

confidence: 99%

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

et al. 2013

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Aims/hypothesis This study aimed to systematically review what has been reported on the incidence and prevalence of type 2 diabetes in children and adolescents, to scrutinise the methodological issues observed in the included studies and to prepare recommendations for future research and surveillances. Methods PubMed, the Cochrane Database of Systematic Reviews, Scopus, EMBASE and Web of Science were searched from inception to February 2013. Population-based studies on incidence and prevalence of type 2 diabetes in children and adolescents were summarised and methodologically evaluated. Owing to substantial methodological heterogeneity and considerable differences in study populations a quantitative meta-analysis was not performed. Results Among 145 potentially relevant studies, 37 population-based studies met the inclusion criteria. Variations in the incidence and prevalence rates of type 2 diabetes in children and adolescents were mainly related to age of the study population, calendar time, geographical regions and ethnicity, resulting in a range of 0-330 per 100,000 personyears for incidence rates, and 0-5,300 per 100,000 population for prevalence rates. Furthermore, a substantial variation in the methodological characteristics was observed for response rates (60-96%), ascertainment rates (53-99%), diagnostic tests and criteria used to diagnose type 2 diabetes. Conclusions/interpretation Worldwide incidence and prevalence of type 2 diabetes in children and adolescents vary substantially among countries, age categories and ethnic groups and this can be explained by variations in population characteristics and methodological dissimilarities between studies.

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“…Em relação à raça das gestantes os dados apresentados também não confirmam os encontrados na literatura, que apontam o aumento dos casos de DM tipo 2 em mulheres de raça não branca [17][18][19] . Em nossa amostra, apesar do ligeiro aumento de casos em gestantes de raça não branca nos últimos anos de estudo em relação aos primeiros, a maioria dos casos corresponderam a gestantes de raça branca.…”

Section: Discussionunclassified

Prognóstico obstétrico de pacientes portadoras de diabetes mellitus pré-gestacional

Fernandes¹,

Simões²,

Figueiredo³

et al. 2012

Rev. Bras. Ginecol. Obstet.

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Sílvia maRgaRida duaRte teixeiRa gueRRa aRagüéS 3 njila Yakalage baRReiRa amaRal 3 Resumo OBJETIVO: Avaliar as alterações epidemiológicas, de perfil clínico e de prognóstico obstétrico em pacientes portadoras de diabetes mellitus pré-gestacional. MÉTODOS: Estudo retrospetivo (coorte) de todas as gestações simples, com diagnóstico de diabetes prévio que foram seguidas num centro com apoio perinatal diferenciado entre 2004 e 2011 (n=194). Analisaram-se tendências relacionadas com dados demográficos e variáveis clínicas maternas, dados de indicadores de cuidados pre-concepcionais e durante a gravidez, e de controle metabólico. Dados do parto como a idade gestacional (IG) do parto, via do parto e peso do neonato foram variáveis também estudadas. RESULTADOS: A frequência global de diabetes prévia, durante o período estudado, foi de 4,4 por mil, não se verificando variações significativas durante o período de estudo. Os casos de diabetes tipo 2 permaneceram constantes. Em 67% dos casos o parto foi de termo (máximo de 80% em 2010-2011), registrou-se uma redução significativa dos partos por cesárea eletiva (p=0,03) e na incidência de neonatos considerados grandes para a IG (p=0,04) ao longo dos anos em estudo. Apesar dos bons resultados relacionados com o controle metabólico ao longo da vigilância da gravidez não foi registrada nenhuma melhora ao longo do tempo. Da mesma forma a proporção de gestantes diabéticas com avaliação pre-concepcional permaneceu pouco animadora. CONCLUSÕES: O seguimento de gestantes portadoras de diabetes mellitus em unidades multidisciplinares parece permitir um ajuste metabólico tão precoce quanto possível, de forma a conseguir melhorar o prognóstico obstétrico. A melhora nos cuidados pré-concepcionais continua sendo um desafio. Abstract PURPOSE:To describe trends in prevalence, indicators of care and pregnancy outcomes for women with pre-existing type I or type II diabetes. METHODS: Cohort study of all consecutive singleton pregnancies complicated by pre-existing type I or type II diabetes followed from 2004 to 2011 at a tertiary perinatal care centre (n=194). We collected data from the medical records and described trends in demographics, clinical history, indicators of care before or during pregnancy and glycaemic control. We also studied perinatal outcomes, including gestational age at delivery, mode of delivery, and birthweight. RESULTS: The overall incidence of pregestational diabetes was 4.4 per 1000, with no significant changes throughout the study period. The number of type 2 diabetes cases also remained constant. In 67% of cases delivery occurred after 37 weeks (maximum 80% in 2010-11). During this period there was a significant reduction in rates of elective caesarean section (p=0.03) and in the incidence of large infants for gestational age (p=0.04). Indicators of glycaemic control were favorable throughout pregnancy, with no significant trends detected during the study period. However, preconceptional care indicators were substandard, with no significant improvement. CONCLUSIONS: ...

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Diabetes in Non-Hispanic White Youth

Cited by 194 publications

References 47 publications

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

Prognóstico obstétrico de pacientes portadoras de diabetes mellitus pré-gestacional

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