Diabetes in North America and The Caribbean: An update

Yisahak, Samrawit F.; Beagley, Jessica; Hambleton, Ian; Narayan, K.M. Venkat

doi:10.1016/j.diabres.2013.11.009

Cited by 57 publications

(45 citation statements)

References 31 publications

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“…Given these potentially grave implications, renal and endocrinology services will need to ensure the full implementation of preventive strategies in order to reduce the expected negative outcomes. With the projected increases in the prevalence of diabetes (21,22) globally and in the Caribbean, the challenge of CKD in patients with diabetes is likely to become an even larger problem in the next decades.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chronic Kidney Disease among Patients Attending a Specialist Diabetes Clinic in Jamaica

Younger-Coleman

et al. 2015

West Indian Med J

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Section: Discussionmentioning

confidence: 99%

Prevalence of Chronic Kidney Disease among Patients Attending a Specialist Diabetes Clinic in Jamaica

Younger-Coleman

et al. 2015

West Indian Med J

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“…A report published by the International Diabetes Federation currently indicates that DM has impact on at least 378 million people worldwide, and this figure is most likely to be doubled by 2035. 1 DM alone is not horrible, but its complications are more than horrible. DM can lead to several ocular complications such as diabetic retinopathy (DR), cataract, glaucoma, etc., which remains a major cause of blindness.…”

Section: Introductionmentioning

confidence: 99%

Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model

Wang

Qin

Pen

et al. 2016

Exp Biol Med (Maywood)

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Ocular complications associated with diabetes mellitus are progressive and becoming one of the most important causes of morbidity worldwide. The purpose of the study is to evaluate the protective effect of Polygonatum sibiricum polysaccharide, an important component of Polygonatum sibiricum, on ocular complications in streptozotocin-induced diabetes mellitus rats. Sprague Dawley rats were made diabetic with streptozotocin(60 mg/kg, i.v.) and then the rats were treated with Polygonatum sibiricum polysaccharide 200, 400 and 800 mg/kg.d by gavage for 12 weeks. Biochemical analysis indicated that Polygonatum sibiricum polysaccharide lowered the levels of fasting blood glucose and glycated hemoglobin in blood and elevated the levels of insulin and C-peptide in plasma of diabetes mellitus rats in a dose-dependent manner. Physical measurements revealed that Polygonatum sibiricum polysaccharide improved clinical symptoms of polydipsia, polyphagia, polyuria and weight loss in diabetes mellitus rats. The content of malondialdehyde and activity of superoxide dismutase in plasma were determined, and the data showed Polygonatum sibiricum polysaccharide suppressed oxidative stress reaction. Lens opacification was observed using slit lamp illumination, and the data showed Polygonatum sibiricum polysaccharide delayed cataract progression in a dose-dependent manner. Electroretinogram showed Polygonatum sibiricum polysaccharide treatment reversed the decrease of electroretinogram b and OPs2 waves' amplitudes. Flash-visual evoked potential test indicated that the peak time of P2 wave was prolonged, and the amplitude of N2-P2 was lowered in diabetes mellitus group, and Polygonatum sibiricum polysaccharide suppressed these changes. Fundus fluorescein angiography showed Polygonatum sibiricum polysaccharide alleviated the retinal vasculopathy in a dose-dependent manner. In conclusion, these results suggest that the administration of Polygonatum sibiricum polysaccharide slows the progression of diabetic retinopathy and cataract through alleviating hyperglycemia and reducing oxidative stress in streptozotocin-induced diabetes mellitus rats.

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“…It should be viewed as a serious threat not just from a public health, but also from a development perspective [1]. Based on a larger number of studies, there will be 439 million adult diabetics by 2030 [2].…”

Section: Introductionmentioning

confidence: 99%

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

Wan

Zhang

et al. 2015

Int J Diabetes Dev Ctries

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Diabetes in North America and The Caribbean: An update

Cited by 57 publications

References 31 publications

Prevalence of Chronic Kidney Disease among Patients Attending a Specialist Diabetes Clinic in Jamaica

Prevalence of Chronic Kidney Disease among Patients Attending a Specialist Diabetes Clinic in Jamaica

Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

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