Diabetes in Pakistan: A systematic review and meta-analysis

Akhtar, Sohail; Nasir, Jamal Abdul; Abbas, Tahir; Sarwar, Aqsa

doi:10.12669/pjms.35.4.194

Cited by 65 publications

(72 citation statements)

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“…The results showed that the pooled prevalence of diabetes was 7.8% and the pooled prevalence of pre-diabetes was 10.1%. By comparing results with other developing countries, the pooled prevalence of diabetes in Bangladesh was shown to be lower than in Nepal 48 (8.4%) and Pakistan 49 (14.7%), while being higher than in Cameroon 50 (5.8%) and China 51 (6.3%). On the other hand, the pooled prevalence of pre-diabetes in Bangladesh was shown to be higher than in Cameroon 50 (7.1%) and lower than in Pakistan 49 (11.43%) and Nepal 48 (10.3%).…”

Section: Discussionmentioning

confidence: 82%

Prevalence of diabetes and pre-diabetes in Bangladesh: a systematic review and meta-analysis

et al. 2020

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ObjectiveThe purpose of this paper is to perform a systematic review and meta-analysis in order to summarise the prevalence of diabetes and pre-diabetes and their associated risk factors in Bangladesh.DesignSystematic review and meta-analysis.ParticipantsGeneral population of Bangladesh.Data sourcesPubMed, Medline, Embase, Bangladesh Journals Online, Science Direct, Scopus, Cochrane Library and Web of Science were used to search for studies, published between 1st of January 1995 and 31st of August 2019, on the prevalence of diabetes and pre-diabetes and their associated risk factors in Bangladesh. Only articles published in the English language articles were considered. Two authors independently selected studies. The quality of the articles was also assessed.ResultsOut of 996 potentially relevant studies, 26 population-based studies, which together involved a total of 80 775 individuals, were included in the meta-analysis. The pooled prevalence of diabetes in the general population was 7.8% (95% CI: 6.4–9.3). In a sample of 56 452 individuals, the pooled prevalence of pre-diabetes was 10.1% (95% CI: 6.7–14.0; 17 studies). The univariable meta-regression analyses showed that the prevalence of diabetes is associated with the factors: the year of study, age of patients and presence of hypertension. The prevalence of diabetes was significantly higher in urban areas compared with rural areas, while there was no significant gender difference.ConclusionsThis meta-analysis suggests a relatively high prevalence of pre-diabetes and diabetes in Bangladesh, with a significant difference between rural and urban areas. The main factors of diabetes include urbanisation, increasing age, hypertension and time period. Further research is needed to identify strategies for early detecting, prevention and treatment of people with diabetes in the population.PROSPERO registration numberCRD42019148205.

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Section: Discussionmentioning

confidence: 82%

Prevalence of diabetes and pre-diabetes in Bangladesh: a systematic review and meta-analysis

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“…Pakistan also belongs to developing countries having sharp rise in diabetic type 2 patients. Meta-analysis of studies revealed high prevalence of diabetic (14.62%) and pre-diabetic individuals (11.43%) in Pakistan [ 3 ]. DM has become a challenge for human health and causes a significant loss to economic health as well [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals of Periploca aphylla Dcne. ameliorated streptozotocin-induced diabetes in rat

Rashid

Khan

2021

Environ Health Prev Med

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Background Periploca aphylla is used by local population and indigenous medicine practitioners as stomachic, tonic, antitumor, antiulcer, and for treatment of inflammatory disorders. The aim of this study was to evaluate antidiabetic effect of the extract of P. aphylla and to investigate antioxidant and hypolipidemic activity in streptozotocin (STZ)-induced diabetic rats. Methods The present research was conducted to evaluate the antihyperglycemic potential of methanol extract of P. aphylla (PAM) and subfractions n-hexane (PAH), chloroform (PAC), ethyl acetate (PAE), n-butanol (PAB), and aqueous (PAA) in glucose-overloaded hyperglycemic Sprague-Dawley rats. Based on the efficacy, PAB (200 mg/kg and 400 mg/kg) was tested for its antidiabetic activity in STZ-induced diabetic rats. Diabetes was induced via intraperitoneal injection of STZ (55 mg/kg) in rat. Blood glucose values were taken weekly. HPLC-DAD analysis of PAB was carried out for the presence of various polyphenols. Results HPLC-DAD analysis of PAB recorded the presence of rutin, catechin, caffeic acid, and myricetin. Oral administration of PAB at doses of 200 and 400 mg/kg for 21 days significantly restored (P < 0.01) body weight (%) and relative liver and relative kidney weight of diabetic rats. Diabetic control rats showed significant elevation (P < 0.01) of AST, ALT, ALP, LDH, total cholesterol, triglycerides, LDL, creatinine, total bilirubin, and BUN while reduced (P < 0.01) level of glucose, total protein, albumin, insulin, and HDL in serum. Count of blood cells and hematological parameters were altered in diabetic rats. Further, glutathione peroxidase, catalase, superoxide dismutase, glutathione reductase, and total soluble protein concentration decreased while concentration of thiobarbituric acid reactive substances and percent DNA damages increased (P < 0.01) in liver and renal tissues of diabetic rats. Histopathological damage scores increased in liver and kidney tissues of diabetic rats. Intake of PAB (400 mg/kg) resulted in significant improvement (P < 0.01) of above parameters, and results were comparable to that of standard drug glibenclamide. Conclusion The result suggests the antihyperglycemic, antioxidant, and anti-inflammatory activities of PAB treatment in STZ-compelled diabetic rat. PAB might be used as new therapeutic agent in diabetic patients to manage diabetes and decrease the complications.

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“…The results showed that the pooled prevalence of diabetes based on 10 population-based cross-sectional studies was 12.14%, with a total sample of 11,699 individuals. Compared with neighbouring countries sharing a similar lifestyle and culture, the pooled prevalence of diabetes in Afghanistan is higher than in Bangladesh (7.7%) [29] and Nepal (8.4%) [30], while lower than in India [31] and Pakistan (14.7%) [32].…”

Section: Discussionmentioning

confidence: 76%

The prevalence of type 2 diabetes in Afghanistan: a systematic review and meta-analysis

Akhtar

Nasir

Javed

et al. 2020

Preprint

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Background The aim of this paper is to investigate the prevalence of diabetes and its associated risk factors in Afghanistan through a systematic review and meta–analysis. Methods A comprehensive literature search was conducted using EMBASE, PubMed, Web of Sciences, Google Scholar and the Cochrane library, carried out from inception to April 31 2020, without language restriction. Meta–analysis was performed using DerSimonian and Laird random-effects models with inverse variance weighting. The existence of publication bias was initially assessed by visual inspection of a funnel plot and then tested by the Egger regression test. Subgroup analyses and meta-regression were used to explore potential sources of heterogeneity. This systematic review was reported by following the PRISMA guidelines and the methodological quality of each included study was evaluated using the STROBE guidelines. Results Out of 64 potentially relevant studies, only 10 studies fulfilled the inclusion criteria and were considered for meta-analysis. The pooled prevalence of diabetes in the general population based on population-based studies were 12.14% (95% CI: 10.06–14.39%), based on a pooled sample of 11,699 individuals. Results of univariate meta-regression analysis revealed that the prevalence of diabetes increased with mean age, hypertension and obesity. There was no significant association between sex (male vs female), smoking, the methodological quality of included articles or education (illiterate vs literate) and the prevalence of diabetes. Conclusions This meta-analysis reports a relatively high prevalence of diabetes in Afghanistan, with the highest prevalence in Kandahar and the lowest in Balkh province. The main risk factors include increasing age, obesity and hypertension. Community-based care and preventive training programmes are recommended. Trial registration: This review was registered on PROSPERO (registration number CRD42020172624).

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Diabetes in Pakistan: A systematic review and meta-analysis

Cited by 65 publications

References 20 publications

Prevalence of diabetes and pre-diabetes in Bangladesh: a systematic review and meta-analysis

Prevalence of diabetes and pre-diabetes in Bangladesh: a systematic review and meta-analysis

Phytochemicals of Periploca aphylla Dcne. ameliorated streptozotocin-induced diabetes in rat

The prevalence of type 2 diabetes in Afghanistan: a systematic review and meta-analysis

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