Diabetes-induced chronic heart failure is due to defects in calcium transporting and regulatory contractile proteins: cellular and molecular evidence

Rupee, Sunil; Rupee, Khemraj; Singh, Ram B.; Hanoman, Carlin; Ismail, Abla Mohammed Ahmed; Smail, Manal M.A.; Singh, Jaipaul

doi:10.1007/s10741-022-10271-5

Cited by 11 publications

(1 citation statement)

References 162 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The production of ROS occurs from RAGE activation via a number of routes, such as the stimulation of oxidative stress pathways, mitochondrial malfunction, and NADPH oxidase activation [ 10 ]. ROS have the ability to enhance calcium signaling by promoting calcium inflow and release from intracellular storage, which occurs downstream of RAGE activation [ 136 ].…”

Section: Quantitative Assessment Techniques For Measuring Rage Activa...mentioning

confidence: 99%

Quantitative Assessment of Intracellular Effectors and Cellular Response in RAGE Activation

Deepu,

Rai,

K. Agrawal

2024

Arch Intern Med Res

View full text Add to dashboard Cite

The review delves into the methods for the quantitative assessment of intracellular effectors and cellular response of Receptor for Advanced Glycation End products (RAGE), a vital transmembrane receptor involved in a range of physiological and pathological processes. RAGE bind to Advanced Glycation End products (AGEs) and other ligands, which in turn activate diverse downstream signaling pathways that impact cellular responses such as inflammation, oxidative stress, and immune reactions. The review article discusses the intracellular signaling pathways activated by RAGE followed by differential activation of RAGE signaling across various diseases. This will ultimately guide researchers in developing targeted and effective interventions for diseases associated with RAGE activation. Further, we have discussed how PCR, western blotting, and microscopic examination of various molecules involved in downstream signaling can be leveraged to monitor, diagnose, and explore diseases involving proteins with unique post-translational modifications. This review article underscores the pressing need for advancements in molecular approaches for disease detection and management involving RAGE.

show abstract

Section: Quantitative Assessment Techniques For Measuring Rage Activa...mentioning

confidence: 99%