Diabetes insipidus and panhypopituitarism revealing pituitary metastasis of small cell lung carcinoma: a case report

Harzallah, L.; Migaw, H.; Harzallah, F.; Kraiem, C

doi:10.1016/s0003-4266(05)81708-1

Cited by 16 publications

(14 citation statements)

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“…Metastatic involvement of the pituitary and infundibular stalk is a rare occurrence (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Primary tumor histologic subtypes which have been documented to spread to the pituitary include lung cancer (NSCLC and SCLC), breast cancer, prostate cancer, renal cell carcinoma, and melanoma (among others), with lung cancer and breast cancer being the most frequently reported [4,5,7,13].…”

Section: Discussionmentioning

confidence: 99%

“…Primary tumor histologic subtypes which have been documented to spread to the pituitary include lung cancer (NSCLC and SCLC), breast cancer, prostate cancer, renal cell carcinoma, and melanoma (among others), with lung cancer and breast cancer being the most frequently reported [4,5,7,13]. Clinical presentations range from isolated diabetes insipidus, to visual loss or diplopia, to full-blown panhypopituitarism [3][4][5][6][7][8][9][10][11]13]. These presenting toxicities have been shown to resolve completely or partially in some but not all cases with acute surgical decompression (via trans-sphenoidal resection), radiation therapy, chemotherapy, and anti-hormonal therapy in the case of metastatic prostatic adenocarcinoma [1,3,7,11].…”

Section: Discussionmentioning

confidence: 99%

“…These presenting toxicities have been shown to resolve completely or partially in some but not all cases with acute surgical decompression (via trans-sphenoidal resection), radiation therapy, chemotherapy, and anti-hormonal therapy in the case of metastatic prostatic adenocarcinoma [1,3,7,11]. Differentiation of a pituitary metastasis from a primary pituitary neoplasm (adenoma or carcinoma) can be difficult [4][5][6][7]. A review of the existing literature performed by investigators at the University of Miami found that it may be possible to distinguish pituitary adenomas from pituitary metastases on clinical grounds, but that radiographic findings were not helpful in this regard [5].…”

Section: Discussionmentioning

confidence: 99%

“…Involvement of the pituitary gland by metastatic disease is extremely rare, with most of the existing data based on individual case reports and literature reviews [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. We recently treated a patient with a prior history of colonic adenocarcinoma who presented postoperatively after transsphenoidal resection of an isolated metastatic lesion involving the sellar floor.…”

Section: Introductionmentioning

confidence: 99%

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Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

et al. 2010

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We present a case report of a patient recently treated at our institution for an isolated non-small cell lung cancer metastatic lesion to the sella, report the lack of involvement of the pituitary gland in a large single-institution series of treated intracranial parenchymal metastases, and review the pertinent literature. We reviewed cranial imaging studies (CT and MRI) for 935 metastases in 155 patients treated at our institution over the previous 3 years for intracranial metastatic disease. Special attention was paid to the skull base to document the presence of any metastatic disease involving the pituitary gland, infundibular stalk, sella turcica (including anterior and posterior clinoids), or diaphragm sellae. We found no other involvement of the pituitary gland or other sellar structures by metastatic disease in this series. Intracranial metastatic disease rarely involves the pituitary gland and infundibular stalk parenchyma, suggesting that this structure may be safely omitted from the treatment field during WBRT and prophylactic cranial irradiation (PCI). This treatment approach should reduce the late sequelae of treatment to this critical organ.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

et al. 2010

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“…[36][37][38][39][40][41][42] The most common tumors which metastasize to the pituitary gland are lung and breast cancer. [43][44][45][46][47][48][49][50][51] Most often, they are part of the generalized metastatic spread, usually associated with more than one metastatic site, particularly osseous. Nonetheless, metastasis to the pituitary may be the initial manifestation of an occult primary tumor or the only site of metastasis.…”

Section: Sellarmentioning

confidence: 99%

Granular cell tumor of the neurohypophysis: Report of a case with intraoperative cytologic diagnosis

Policarpio‐Nicolas

Mandell

et al. 2007

Diagnostic Cytopathology

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Cytological techniques including touch and smear preparations are very useful diagnostic modality in the evaluation of central nervous system (CNS) lesions and, in many instances, may be effectively used as the sole modality of tissue preparation for intraoperative consultation. Cytologic preparations offer many advantages over frozen sections for CNS specimens. These include selective examination of multiple areas from small biopsy specimens, superior preservation and details of cellular morphology, fewer artifacts, faster results, and improved costeffectiveness. We describe the cytologic diagnosis of a granular cell tumor (GCT) of the neurohypophysis in a 33-year-old male who presented with headache and blurred vision. CT scan revealed an enlarged sella with a 2.15 3 2.0 cm pituitary lesion. Transsphenoidal resection of the mass was performed and submitted for intraoperative consultation. Smears and touch preparations were made on a portion of the mass that showed uniform polygonal cells with round to ovoid nuclei and abundant eosinophilic granular cytoplasm. An intraoperative cytological diagnosis of ''favor GCT'' was rendered. The histologic sections of the remaining material confirmed the diagnosis. Although GCT of the neurohypophysis is very rare, a specific intraoperative cytological diagnosis is possible. We report the clinical, cytological, and pathological findings of a GCT affecting the neurohypophysis. Diagn. Cytopathol. 2008;36:58-63. ' 2007 Wiley-Liss, Inc.Key Words: granular cell tumor; neurohypophysis; intraoperative smear preparation Granular cell tumors (GCTs) have been reported in many sites of the body including the breast, skin, and larynx. However, head and neck have been the most common sites. GCT has a distinctive appearance on cytology, so that it has been suggested to be an effective method for accurate diagnosis even though some reports focus on the difficulties in cytological differential diagnosis. [1][2][3][4][5][6] Within the central nervous system (CNS), GCTs usually occur as intrasellar and/or suprasellar mass arising from the neurohypophysis or infundibulum. On histologic sections and cytological smears, GCT is composed of nests of large cells with small round to oval nucleus and abundant granular eosinophilic cytoplasm, arranged as individual cells or in clusters. Although the cytology of GCT in other sites has been reported in the English literature, 7-17 to our knowledge, there has been no report on the intraoperative touch/squash cytology of this tumor. We report the first case of GCT of the neurohypophysis diagnosed on cytological preparations during an intraoperative consultation, illustrating the value of intraoperative cytology as a well recognized and reliable diagnostic modality for rapid interpretation and even classification of neuropathologic specimens. Case ReportThe patient is a 33-year-old male with history of progressively worsening headache for 2 years. He presented to our hospital for fever, severe headache, nausea, vomiting, and blurred vision. Cerebrospinal...

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Dural and Skull Base Metastases

Silva

Schiff

2007

Brain Metastases

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Diabetes insipidus and panhypopituitarism revealing pituitary metastasis of small cell lung carcinoma: a case report

Cited by 16 publications

References 5 publications

Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

Granular cell tumor of the neurohypophysis: Report of a case with intraoperative cytologic diagnosis

Dural and Skull Base Metastases

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