Diabetes Insipidus Pascaoperasi pada Pasien dengan Reseksi Tumor Kraniofaringioma

Abstract

Craniopharyngioma is an embryonic malformation in the sella and parasella areas. Craniopharyngioma has high survival rate, although the patient's quality of life is often compromised due to tumor’s location near important anatomical structures such as the optic nerve, optic chiasm, and hypothalamic-pituitary axis. Craniopharyngioma tumor resection can provoke diabetes insipidus. Diabetes insipidus (DI) is characterized by polyuria, dehydration and hypernatremia due to vasopressin or antidiuretic hormone (ADH) deficiency. A 20 years old male patient complained of polyuria, paresthesia in both hands, rapid body growth, and headaches. Brain magnetic resonance imaging (MRI) with contrast revealed cystic mass in the parasella cistern region suggested craniopharyngioma. This patient underwent craniotomy tumor resection under general anesthesia and additional scalp block. Postoperatively the patient experienced an increased urine volume up to 400 ml/hour and fluid replacement was performed with crystalloids Ringerfundin and D5 ¼ NS. The patient suffered DI and vasopressin was continued in the postoperative period until urine output reduced to <2 ml/kg/hour. Perioperative management of craniopharyngioma is controlling intracranial pressure, prevent secondary brain injury and postoperative monitoring in the intensive care unit to manage potential complications such as DI. In this case, patient suffered polyuria and increased plasma sodium levels which was safely treated by administration of vasopressin and rehydration to maintain fluid adequacy and balance of plasma sodium levels