Diabetes is an Independent Risk Factor for Stroke Recurrence in Stroke Patients: A Meta-analysis

Diabetes and ischaemic stroke outcome

“…Risk of 30-day and 1-year all-cause mortality was 8.4% and 20.5%, respectively, for people with diabetes who experienced stroke. We saw a positive but insignificant association between diabetes and stroke recurrence that fell within the range presented by Shou et al [11] in their meta-analysis. People who had experienced stroke with diabetes were roughly 1.5 times more likely to die at 1 year compared with those without diabetes after accounting for confounders.…”

“…A 2015 meta-analysis of 14 studies found a significantly increased hazard ratio of 1.44 (95% CI 1.28, 1.61) for the effect of diabetes on stroke recurrence after ischaemic stroke [11]; however, the majority of the studies in this meta-analysis were older, including studies conducted in the 1980s and 1990s, and many were focused on very select populations. A 2015 meta-analysis of 14 studies found a significantly increased hazard ratio of 1.44 (95% CI 1.28, 1.61) for the effect of diabetes on stroke recurrence after ischaemic stroke [11]; however, the majority of the studies in this meta-analysis were older, including studies conducted in the 1980s and 1990s, and many were focused on very select populations.…”

“…Because the rate of stroke recurrence is low, lack of power is a significant limitation for estimating the effect of diabetes on stroke recurrence in individual studies. A 2015 meta-analysis of 14 studies found a significantly increased hazard ratio of 1.44 (95% CI 1.28, 1.61) for the effect of diabetes on stroke recurrence after ischaemic stroke [11]; however, the majority of the studies in this meta-analysis were older, including studies conducted in the 1980s and 1990s, and many were focused on very select populations. Further, the meta-analysis included results from only one population-based study, which considered a combined ischaemic and haemorrhagic stroke population identified for the period 1995 to 2008.…”

Diabetes mellitus and stroke: A clinical update

“…Table 1 summarises the results of relevant prospective studies demonstrating the relative risk of ischaemic stroke in different diabetes populations worldwide[10-20]. Cardiometabolic risk factors including obesity, hypertension, and dyslipidaemia often co-exist with T2DM and can contribute to the higher reported relative stroke risks when compared to patients with similar risk profile without diabetes[8,21-23]. …”

“…Table 2 summarises prospective studies highlighting stroke patterns and risk factors identified in patients with diabetes. Prognostic features also differ from normal stroke population as diabetes is associated with an increased risk of subsequent strokes, greater functional disability, longer in-hospital stay, and increased mortality[8,34]. A higher risk of developing stroke-related dementia has also been reported[35].…”