Diabetes is a disorder that affects metabolism of carbohydrates, fats, and proteins. It has appeared as one of the deadliest pandemics causing 3.2 million deaths per year. The objective of current study was to assess the level of awareness and practice of diabetic patients who were diagnosed with Type-II diabetes mellitus (DM). A prospective, observational study was designed, and subjects of the study were the patients visiting the clinics of Nawabshah Shaheed Benazirabad. The study was conducted from September 2019 to February 2020 among 300 Type-II DM patients with minimum of 34 years of age, who had been diagnosed according to the set criteria of World Health Organization (WHO). The criteria for the sampling were set to be done by non-probability convenient sampling technique. For the collection of the data, diabetes knowledge questionnaire was used, and SPSS 25 software was used for the analysis of the collected data. The statistical analysis generated was descriptive in nature. Majority of participants were male patients (n=158, 52.7%) and major age group was >65 (n=136, 45.33%). The patients with family history of the disease were 253 (84.3%) of the total cases. The patients having poor knowledge of the disease and those with satisfactory practice and routine follow up were 207 (69.0%) and 160 (53.3%) respectively. The results show that the patients had poor knowledge of the diabetes. The practice regarding diabetes falls under the category of average routine practice. It can be concluded from the results that for the awareness of the diabetes there should be arrangements of the campaigns for the general population and with the involvement of the clinical pharmacist and endocrinologist, and by that diabetes could be managed effectively.