Diabetes medications: Impact on inflammation and wound healing

Salazar, Jay J.; Ennis, William J.; Koh, Timothy J.

doi:10.1016/j.jdiacomp.2015.12.017

Cited by 162 publications

(113 citation statements)

References 72 publications

(85 reference statements)

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…We found profound changes in serum hormonal profiles of pre-pubertal non-obese allergic children compared to non-allergic controls, as well as chronic rhinosinusitis patients compared to healthy controls, including decreased levels in serum insulin and increased output of thyroid and growth hormones 96 . Hormones play a critical role in maintenance of epithelial barrier homeostasis and integrity via their integration with epithelial morphogenetic programs 88, 97 , evidenced by deficiencies in wound healing and epithelial dysfunction in patients with thyroid disease and diabetes 98, 99 . Insulin and IGF-1 are essential drivers of epithelial differentiation and regulators of energy metabolism.…”

Section: Mechanisms Of Barrier Defectsmentioning

confidence: 99%

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Schleimer

Berdnikovs

2017

Journal of Allergy and Clinical Immunology

141

122

View full text Add to dashboard Cite

Epithelial barriers of the skin, gastrointestinal tract and airway serve common critical functions such as maintaining a physical barrier against environmental insults and allergens, as well as providing a tissue interface balancing the communication between the internal and external environments. We now understand that in allergic disease, regardless of tissue location, the homeostatic balance of the epithelial barrier is skewed towards loss of differentiation, reduced junctional integrity and impaired innate defense. Importantly, epithelial dysfunction characterized by these traits appears to pre-date atopy and development of allergic disease. Despite our growing appreciation of the centrality of barrier dysfunction in the initiation of allergic disease, many important questions remain to be answered regarding the mechanisms disrupting the normal barrier function. Although our external environment (proteases, allergens, injury) is classically thought of as a principal contributor to barrier disruption associated with allergic sensitization, there is a need to better understand contributions of the internal environment (hormones, diet, circadian clock). Systemic drivers of disease, such as alterations of the endocrine system, metabolism and aberrant control of developmental signaling, are emerging as new players in driving epithelial dysfunction and allergic predisposition at various barrier sites. Identifying such central mediators of epithelial dysfunction, using both systems biology tools and causality-driven laboratory experimentation, will be essential in building new strategic interventions to prevent or reverse the process of barrier loss in allergy.

show abstract

Section: Mechanisms Of Barrier Defectsmentioning

confidence: 99%

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Schleimer

Berdnikovs

2017

Journal of Allergy and Clinical Immunology

141

122

View full text Add to dashboard Cite

show abstract

“…Drugs studied showed potency in stimulating angiogenesis and formation of granulation tissue necessary in wound healing. 21 Oral mucosa in diabetic patients has different structure to people without DM due to prolong hyperglycemic condition. Insulin deficiency was assumed to have a direct effect in changes of vascularization and blood flow to the connective tissue.…”

Section: Discussionmentioning

confidence: 99%

Psychological Stress and Diabetes Mellitus As Complicating Factors in Management of Pemphigus Vulgaris

Ramadian

Sarsito

2017

UIP HEATH MED

View full text Add to dashboard Cite

Introduction: Pemphigus vulgaris (PV) is an autoimmune disease with vesiculobullous lesions that attack the skin and mucosa including oral mucosa. There are some factors that can trigger the recurrence of PV; one of them is psychological stress. PV is treated using immunosuppressant agents like corticosteroids or other immunosuppressant drugs. Complete remission in PV often hard to achieve because of some trigger factors that is hard to control and systemic disease like diabetes mellitus (DM).

show abstract

“…The initial stage of repair and the proliferation of apoptosis after deep burns has the following adverse effects: Growth factor expression is weakened, granulation of the wounded tissues is not normal and consequently the survival rate of free flaps is not high due to the lack of a nurturing environment. Previous experiments conducted on animals have revealed that local application of low-dose insulin can promote wound healing in a diabetic rat model with scalds (8). High glucose conditions may lead to suppression of vascular endothelial cell proliferation, weakened cell contacts and increased apoptosis of the cells.…”

Section: Discussionmentioning

confidence: 99%

Clinical study on local application of low-dose insulin for promoting wound healing after operation for deep burns

Zeng

Zhi

Liu

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Transplanted free skin flaps are often needed to treat deep burns; their survival, however, is less than optimal. This study examined whether local low-dose insulin injections can promote flap survival and wound healing after surgery. A total of 165 patients who underwent free skin flap transplantation for simple deep burns were enrolled in the study and divided into 5 groups of 33 patients each: Blank control group (no local subcutaneous drug injections), saline control group (saline injections), low-dose insulin group (0.5 units regular insulin injections), medium-dose group (1.0 units regular insulin injections) and high-dose group (2.0 units regular insulin injections). Wound healing and flap survival conditions were assessed and compared among groups. The best wound healing rate found was that of the low-dose insulin injection group where all the parameters measured improved significantly: The healing time was shorter; the blood flow volume, the flap survival, the number of fibroblasts and new vessels increased; the re-epithelialization occurred faster; the infiltration of inflammatory cells was reduced; the expression levels of heat shock protein-90, vascular endothelial growth factor, transforming growth factor-β and interleukin-1 were higher; and the plasma glucose levels only fluctuated slightly. The results clearly demonstrate that a local low-dose insulin regime after flap transplantation can accelerate the healing time and improve the surgical outcome without exerting detrimental secondary effects on the glucose plasma level of deep burn patients.

show abstract

Diabetes medications: Impact on inflammation and wound healing

Cited by 162 publications

References 72 publications

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Psychological Stress and Diabetes Mellitus As Complicating Factors in Management of Pemphigus Vulgaris

Clinical study on local application of low-dose insulin for promoting wound healing after operation for deep burns

Contact Info

Product

Resources

About