Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral bone

Wang, Huajun; Giambini, Hugo; Chen, Jiwen; Wang, Qiushi; Hou, Huige; Luo, Simin; Chen, Jun-Yuan; Zhuang, Tengfeng; Chen, Yong; Wang, Tingting; Zha, Zhengang; Liu, You-Jie; Zheng, Xiaofei

doi:10.21037/atm-20-6797

Cited by 18 publications

(11 citation statements)

References 42 publications

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“…Chen et al (2017) reported that subchondral bone remodelling led to deteriorated microstructure and strength, which in turn aggravated cartilage degradation in type 2 diabetes patients. In a mouse model, Wang et al (2021) also found that diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating subchondral bone microarchitecture. Using a mouse model with spontaneously hypertensive heart failure and obesity, Deng et al (2018) evaluated the contribution of metabolic syndrome to OA development, which exhibited knee joints with severe loss of the entire thickness of the cartilage A conceptual model of OA including pathogenesis, symptoms, risk factors and treatments.…”

Section: Metabolic Disordersmentioning

confidence: 84%

Physical therapy as a promising treatment for osteoarthritis: A narrative review

2022

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Osteoarthritis (OA) is the most prevalent joint disease and a leading cause of disability in older adults. With an increasing population ageing and obesity, OA is becoming even more prevalent than it was in previous decades. Evidence indicates that OA is caused by the breakdown of joint tissues from mechanical loading and inflammation, but the deeper underlying mechanism of OA pathogenesis remains unclear, hindering efforts to prevent and treat this disease. Pharmacological treatments are mostly related to relieving symptoms, and there is no drug for radical cure. However, compelling evidence suggests that regular practice of resistance exercise may prevent and control the development of several musculoskeletal chronic diseases including OA, which may result in improved quality of life of the patients. In this review, we introduced the current understanding of the mechanism and clinical treatments of OA pathogenesis. We also reviewed the recent study of physical therapy in the treatment of skeletal system disorders, especially in OA. Finally, we discuss the present challenges and promising advantages of physical therapy in OA treatment.

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Section: Metabolic Disordersmentioning

confidence: 84%

Physical therapy as a promising treatment for osteoarthritis: A narrative review

2022

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“…The histological severity of OA was also remarkably higher in the diabetic group compared to the control group of mice. A diabetic microenvironment facilitates the development of OA by promoting accelerated synthesis and accumulation of AGEs, further increasing the oxidative burden by impairing healing and elasticity [ 6 ] (Figure 2 ). A study conducted by Dubey et al concluded that the increased glycation products in diabetic mice increasingly induce matrix metalloproteinase expression as well as reduce chondrocytes-specific protein expressions such as SOX9, COl 2, and aggrecan [ 3 ].…”

Section: Reviewmentioning

confidence: 99%

“…The US Third National Health and Nutrition Examination Survey (NHANES III) recently performed a cross-sectional study, which demonstrated a higher prevalence of DM in those with OA as compared to the general population [ 4 ]. Furthermore, it was reported that DM plays a unique role of its own in the progression and pathogenesis of OA [ 4 , 6 ]. Even hyperglycemia alone was reported to be associated with a separate mechanism on the pathogenesis and advancement of OA through the accumulation of advanced glycation end products (AGEs), oxidative stress, and dysregulation of articular cartilage metabolism [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Association Between Diabetes Mellitus and Osteoarthritis: Does Diabetes Mellitus Play a Role in the Severity of Pain in Osteoarthritis?

Chowdhury¹,

Bellamkonda²,

Gousy³

et al. 2022

Cureus

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Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, which results in the inevitable destruction of joints leading to pain and joint immobility. Some studies have reported a potential link between diabetes mellitus (DM) and the worsening symptoms and severity of OA. Based on our literature review, the microcellular environment of patients with DM showed accelerated joint destruction and increased inflammation in every anatomical aspect of the joint including the bones, tendons, ligaments, cartilage, and synovium. Additionally, the biomechanical and biochemical properties of these tissues were more severely impacted in patients with DM and OA compared to those without DM, suggesting that DM plays an important role in the pathogenesis of OA. Specifically, we found that advanced glycation end products (AGEs) are the key to inducing the acceleration of joint destruction; however, their role in the pathogenesis has yet to be fully mapped out. In this narrative review, we aim to explore the role that DM plays in the acceleration of OA leading to increased reports of joint pain in those with both diseases. We believe this topic of discussion to be important due to the increased prevalence of both diseases over the last several decades, potentially leading to an increased medical burden on both patients and the community at large.

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“…Diabetes mellitus (DM) and osteoporosis are major public health problems in the aging population affecting people all over the world and are of serious health and financial concern ( 1 ). DM can cause great harm to the human body, among which chronic complications of skeletal system have a high rate of death and disability, which can cause long-term bone pain and lead to diabetic osteoporosis ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical effect of kyphoplasty in the treatment of osteoporotic thoracolumbar compression fractures in patients with diabetes

et al. 2023

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ObjectiveTo study the clinical effect and influencing factors of kyphoplasty in the treatment of osteoporotic thoracolumbar compression fractures (OTCF) complicated with type 2 diabetes mellitus (T2DM).MethodsA total of 472 patients with OTCF complicated with diabetes who were enrolled in our hospital from January to December 2019 were selected as the study subjects, and all patients were treated with percutaneous kyphoplasty (PKP). The effects of gender, age, smoking, drinking, body mass index (BMI), bone mass density (T score), fasting blood glucose level, fasting C-peptide, glycosylated hemoglobin, course of T2DM, vertebral segment and surgical instrument on postoperative improvement were analyzed. The quality of life was evaluated by visual analog score (VAS) and Oswestry disability index (ODI) before PKP and 7 days, and 6 months after PKP, and the patient satisfaction was assessed by the modified Macnab criteria at 6 months postoperatively.ResultsThe overall excellent and good rate of evaluation result was satisfactory. In multivariate regression, independent risk factors for poor patient satisfaction included: age ≥70 years (odds ratio (OR) = 2.298, 95% confidence interval [CI] 1.290–4.245, P = 0.025), fasting blood glucose ≥8 mmol/L [OR = 2.657, 95%(CI) 1.288–4.121, P = 0.016], glycosylated hemoglobin ≥6.5 mmol/L [OR = 3.438, 95%(CI) 2.543–4.628, P = 0.001], duration ≥8 years [OR = 1.732, 95%(CI) 1.471–3.253, P = 0.019] and Kyphon instrument [OR = 1.472, 95%(CI) 1.112–2.228, P = 0.018] were independent influencing factors of OTCF complicated with DM.ConclusionKyphoplasty for patients with osteoporotic thoracolumbar compression fractures complicated with diabetes can achieve a satisfactory clinical effect, the curative effect is affected by many factors, attention to these factors can improve the clinical effect.

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Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral bone

Cited by 18 publications

References 42 publications

Physical therapy as a promising treatment for osteoarthritis: A narrative review

Physical therapy as a promising treatment for osteoarthritis: A narrative review

The Association Between Diabetes Mellitus and Osteoarthritis: Does Diabetes Mellitus Play a Role in the Severity of Pain in Osteoarthritis?

Clinical effect of kyphoplasty in the treatment of osteoporotic thoracolumbar compression fractures in patients with diabetes

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