Diabetes mellitus alters electrophysiological properties in neurons of superior cervical ganglion of rats

Silva-dos-Santos, Nathalia Maria; Oliveira-Abreu, Klausen; Moreira-Júnior, Luiz; Santos-Nascimento, Tiago dos; Silva‐Alves, Kerly Shamyra da; Coelho‐de‐Souza, Andrelina Noronha; Ferreira-da-Silva, Francisco Walber; Leal-Cardoso, José Henrique

doi:10.1016/j.brainres.2019.146599

Cited by 10 publications

(14 citation statements)

References 52 publications

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“…Several studies have described the effects of melatonin treatment on DM and DNP using different approaches. Melatonin is known to suppress the upregulation of oxygen and nitrogen free radicals in DM ( Adeghate, Rashed, Rajbandari, & Singh, 2006 ; Silva-dos-Santos et al, 2020 ). Melatonin is also known to suppress the overexpression of DM-induced inflammatory biomarkers’ levels including TNF-α, IL-6, iNOS, and leptin ( Adeghate et al, 2006 ; Silva-dos-Santos et al, 2020 ).…”

Section: Effect Of Melatonin Treatment On Diabetic Neuropathy In Expe...mentioning

confidence: 99%

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

et al. 2022

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Pre-diabetes and diabetes are growing threats to the modern world. Diabetes mellitus (DM) is associated with comorbidities such as hypertension (83.40%), obesity (90.49%), and dyslipidemia (93.43%), creating a substantial burden on patients and society. Reductive and oxidative (Redox) stress level imbalance and inflammation play an important role in DM progression. Various therapeutics have been investigated to treat these neuronal complications. Melatonin and dipeptidyl peptidase IV inhibitors (DPP-4i) are known to possess powerful antioxidant and anti-inflammatory properties and have garnered significant attention in the recent years. In this present review article, we have reviewed the recently published reports on the therapeutic efficiency of melatonin and DPP-4i in the treatment of DM. We summarized the efficacy of melatonin and DPP-4i in DM and associated complications of diabetic neuropathy (DNP) and neuropathic pain. Furthermore, we discussed the mechanisms of action and their efficacy in the alleviation of oxidative stress in DM.

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Section: Effect Of Melatonin Treatment On Diabetic Neuropathy In Expe...mentioning

confidence: 99%

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

et al. 2022

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“…STZ is an antibiotic produced by Streptomyces achromogenes that selectively destroys pancreatic β cells, thus interfering with insulin synthesis and consequently, glycemic control [ 19 , 20 ]. Using STZ as a model, previous studies have reported important changes caused by DM in the CNS [ 22 ] and PNS, such as in the dorsal root ganglia (DRG) [ 23 ] and in the superior cervical ganglion (SCG) of Wistar rats [ 24 ].…”

Section: Diabetic Neuropathy and Retinopathymentioning

confidence: 99%

“…Regarding the active electrophysiological properties, a tendency for rheobase reduction was observed, suggesting increased excitability of SFP neurons. Finally, although the effects of DM were observed for a relatively short period, they were sufficient to inhibit Na + K + ATPAse pump activity [ 24 ].…”

Section: Diabetic Neuropathy and Retinopathymentioning

confidence: 99%

Effects of Melatonin on Diabetic Neuropathy and Retinopathy

Oliveira-Abreu

Cipolla‐Neto

Leal‐Cardoso

2021

IJMS

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Diabetes mellitus (DM) leads to complications, the majority of which are nephropathy, retinopathy, and neuropathy. Redox imbalance and inflammation are important components of the pathophysiology of these complications. Many studies have been conducted to find a specific treatment for these neural complications, and some of them have investigated the therapeutic potential of melatonin (MEL), an anti-inflammatory agent and powerful antioxidant. In the present article, we review studies published over the past 21 years on the therapeutic efficacy of MEL in the treatment of DM-induced neural complications. Reports suggest that there is a real prospect of using MEL as an adjuvant treatment for hypoglycemic agents. However, analysis shows that there is a wide range of approaches regarding the doses used, duration of treatment, and treatment times in relation to the temporal course of DM. This wide range hinders an objective analysis of advances and prospective vision of the paths to be followed for the unequivocal establishment of parameters to be used in an eventual therapeutic validation of MEL in neural complications of DM.

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“…Статистичний аналіз показав, що наведені електрофізіологічні параметри нейронів ВШГ контрольної групи та у щурів з ЦД достовірно не відрізнялися. Це може пояснюватися тим, що незважаючи на відмінності у морфологічних, функціональних та електрофізіологічних властивостях нейронів ВШГ, деякі електрофізіологічні показники у більшості цих клітин досить схожі і не змінюються за умов ЦД [3,6].…”

Section: результати та їх обговоренняunclassified

Synaptic Responses of Superior Cervical Ganglion Neurons of Rats With Experimental Diabetes Mellitus

Nastenko¹,

Purnyn²,

Fedulova³

et al. 2021

Fiziol Zh

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Excitatory postsynaptic potentials (EPSP) were recorded from the superior cervical ganglion neurons (SCG) in the rats with experimental streptozotocininduced diabetes (ESD). EPSP was inducted by electrical stimulation of the cervical sympathetic trunk. It was founded that the average value of the EPSP time constant decay in the rats with ESD was 15% higher. At the same time, the amplitudes of EPSP of SCG neurons and the hexamethonium blocking effect in the rats with ESD on 30th day after streptozotocin injection didn’t differ significantly from those in control rats. This may indicate specific functional disorders associated as with steady-state elevated blood glucose level in rats as SCG neurons nicotinic cholinergic receptors.

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Diabetes mellitus alters electrophysiological properties in neurons of superior cervical ganglion of rats

Cited by 10 publications

References 52 publications

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

Effects of Melatonin on Diabetic Neuropathy and Retinopathy

Synaptic Responses of Superior Cervical Ganglion Neurons of Rats With Experimental Diabetes Mellitus

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