Diabetes Mellitus among Newly Diagnosed  Tuberculosis Patients in Tribal Odisha:  An Exploratory Study

Manjareeka, Magna; Sk, Palo; Swain, Subhashisa; Pati, Sanghamitra

doi:10.7860/jcdr/2016/20999.8704

Cited by 15 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this is higher than reports from India and other neighboring countries. A South Indian study on tribal had observed a lower prevalence of DM compared to the present study [23]. Recent study from Vietnam reported 29% of prediabetic and 13.7% diabetics among the PT individuals and the authors also reported 8.8% rise in prevalence of TB among DM compared to their previous report [24].…”

Section: Discussioncontrasting

confidence: 54%

A pilot study to find the prevalence of diabetes mellitus among newly diagnosed pulmonary tuberculosis and individuals on anti-tuberculosis treatment

Sarma

Chandra

2020

Trop J Pathol Microbiol

View full text Add to dashboard Cite

Introduction: Diabetes Mellitus (DM) is a known risk factor of tuberculosis (TB). Moreover, the risk of getting TB is 3 times more among diabetics compared to the non-diabetics. Materials and methods: Study was conducted in department of Microbiology, GSL Medical College, Rajahmundry. Individuals aged ≥ 18yeras were included in the study. The study participants were divided into two groups. Group A consist of newly diagnosed pulmonary tuberculosis (PT) individuals and individuals on anti-tuberculosis treatment (ATT) were included in group B. Two spot sputum samples were collected from the participants, same day sputum collection approach; smear was stained by Ziehl Neelsen staining technique. Blood sample was collected and analyzed by HbA1C technique for sugar estimation. Results: In group A, 17%, 33% and 50% individuals were diagnosed to be normal, prediabetic and diabetic respectively. Whereas this was 7%, 20% and 73% respectively among group B. Age wise, individuals with diabetes were increased in both groups. Conclusion: Diabetes is more among the individuals who are on ATT compared to newly diagnosed PT cases. Studies with large sample size are recommended.Several studies regarding DM and TB were reported but the results are ambiguous. Some studies reported low [7,8] smear positivity among DM and high-grade smear positivity [9,10] was also reported. Moreover, the present study did not find reports on DM and TB from East Godavari district where the burden of TB is high. With this a study was planned with an aim to find the prevalence of DM among newly diagnosed PT and individuals on antituberculosis treatment (ATT).

show abstract

Section: Discussioncontrasting

confidence: 54%

A pilot study to find the prevalence of diabetes mellitus among newly diagnosed pulmonary tuberculosis and individuals on anti-tuberculosis treatment

Sarma

Chandra

2020

Trop J Pathol Microbiol

View full text Add to dashboard Cite

show abstract

“…Most studies were judged at a high risk of bias for item number three of the selection category description of the non-response rate. Only 12 studies have adequately described the non-response rate in the study 21 , 24 , 27 , 32 , 37 , 38 , 40 , 51 , 56 , 64 , 79 , 83 (Supplementary Table 3 ). The mean NOS score assessing the impact of diabetes among TB treatment outcome was seven (of a possible nine points), suggesting that the high quality of the studies was included in the meta-analysis (Supplementary Table 6 ).…”

Section: Resultsmentioning

confidence: 99%

Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: a systematic review and meta-analysis

Gautam

Shrestha²,

Mahato

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The escalating burden of diabetes is increasing the risk of contracting tuberculosis (TB) and has a pervasive impact on TB treatment outcomes. Therefore, we conducted this systematic review and meta-analysis to examine the burden of diabetes among TB patients and assess its impact on TB treatment in South Asia (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, India, Pakistan, and Sri Lanka). PubMed, Excerpta Medica Database (EMBASE), and CINAHL databases were systematically searched for observational (cross-sectional, case–control and cohort) studies that reported prevalence of diabetes in TB patients and published between 1 January 1980 and 30 July 2020. A random-effect model for computing the pooled prevalence of diabetes and a fixed-effect model for assessing its impact on TB treatment were used. The review was registered with PROSPERO number CRD42020167896. Of the 3463 identified studies, a total of 74 studies (47 studies from India, 10 from Pakistan, four from Nepal and two from both Bangladesh and Sri-Lanka) were included in this systematic review: 65 studies for the prevalence of diabetes among TB patients and nine studies for the impact of diabetes on TB treatment outcomes. The pooled prevalence of diabetes in TB patients was 21% (95% CI 18.0, 23.0; I2 98.3%), varying from 11% in Bangladesh to 24% in Sri-Lanka. The prevalence was higher in studies having a sample size less than 300 (23%, 95% CI 18.0, 27.0), studies conducted in adults (21%, 95% CI 18.0, 23.0) and countries with high TB burden (21%, 95% CI 19.0, 24.0). Publication bias was detected based on the graphic asymmetry of the funnel plot and Egger’s test (p < 0.001). Compared with non-diabetic TB patients, patients with TB and diabetes were associated with higher odds of mortality (Odds Ratio (OR) 1.7; 95% CI 1.2, 2.51; I2 19.4%) and treatment failure (OR 1.7; 95% CI 1.1, 2.4; I2 49.6%), but not associated with Multi-drug resistant TB (OR 1.0; 95% CI 0.6, 1.7; I2 40.7%). This study found a high burden of diabetes among TB patients in South Asia. Patients with TB-diabetes were at higher risk of treatment failure and mortality compared to TB alone. Screening for diabetes among TB patients along with planning and implementation of preventive and curative strategies for both TB and diabetes are urgently needed.

show abstract

“…The prevalence of high FBS was found to be higher in newly diagnosed pulmonary TB patients. 31 At least 15% of the DM patients tend to be newly-diagnosed and younger emphasises the importance of early DM diagnosis at TB clinics. 32 Developing countries with an alarming TB endemic and TB-DM association might be the next universal threat.…”

Section: Clinical Risk Factorsmentioning

confidence: 99%

Clinico-radiological variability of pulmonary tuberculosis in young patients as compared to elder patients prior to RNTCP and after 18 years RNTCP

et al. 2018

View full text Add to dashboard Cite

Background: Tuberculosis, a chronic disease causing high morbidity and mortality with multiple host related and socio-demographic risk factors. Incidence is 3-4 times among in diabetics. HIV is considered to be a most powerful risk factor other being malnutrition, Tubercular contacts, smoking habits and alcoholism. Many ecological and societal threats increase a vulnerability to infection and succession of the disease. Objective was to study and compare various clinico-radiological presentations and clinical risk factors for pulmonary tuberculosis in the young (<50yrs) and elderly (>50yrs) patients.Methods: Total 300 pulmonary tuberculosis patients each admitted in hospital during 1999 (group ‘A’) and 2016 (group ‘B’) respectively were included in our study. Socio-demographic risk factors and presence of any existing co morbidities and clinical as well radiological presentation data were evaluated.Results: Majority patients in both group ‘A’ and ‘B’ were males (67% and 61.3%), younger (71.3% and 63.3%) patients. Elder patients had more smokers in both groups (48.8% and 33.6%). COPD trends seems to be receding in group ‘B’ as compared to group ‘A’ in younger (6.3% vs. 8.9%) as well elder (13.6% vs. 29.1%) but on the contrary lifestyle disease trends like DM increased in group ‘B’ than group ‘A’ patients more in elder subgroup (30% vs. 9.3%). HIV infected was more in younger 2.1 % (elder 0.9%) group ‘B’ patients. Haemoptysis (17.8% and 18.6% vs. 13.7% and 9.1%) and cough (~87% vs. ~85%) were almost similar but fever (~90% vs. ~65%) was seen significantly higher in the young patients. Radiologically bilateral upper lobe cavitations (15%-30%) was a higher in group A patients as compared to negligible less than ~3% cavitations in group B, on the contrary infiltrations (15%-32%) was more in group B.Conclusions: Young adults are more likely to have fever while haemoptysis cough and advanced lung field involvement is more common in elderly. Elderly patients had a higher number of co-morbidities like COPD and DM. The present study reveals that various demographic, socioeconomic and clinical risk factors have a potential role in causation/augmentation of pulmonary tuberculosis hence life style modification, prevention and timely management of these risk factors could be helpful to reduce the burden of disease.

show abstract

Diabetes Mellitus among Newly Diagnosed Tuberculosis Patients in Tribal Odisha: An Exploratory Study

Cited by 15 publications

References 22 publications

A pilot study to find the prevalence of diabetes mellitus among newly diagnosed pulmonary tuberculosis and individuals on anti-tuberculosis treatment

A pilot study to find the prevalence of diabetes mellitus among newly diagnosed pulmonary tuberculosis and individuals on anti-tuberculosis treatment

Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: a systematic review and meta-analysis

Clinico-radiological variability of pulmonary tuberculosis in young patients as compared to elder patients prior to RNTCP and after 18 years RNTCP

Contact Info

Product

Resources

About