Diabetes mellitus and hip fracture: A study of 5966 cases

Diabetes Confers Little to No Increased Risk of Postoperative Complications After Hip Fracture Surgery in Geriatric Patients

“…It was not until 24 months after hip fracture surgery that an increased risk of congestive heart failure and renal failure in patients with diabetes was detected. Both studies [10,22] are consistent with the findings of our study. The only differences were an increased risk of pressure ulcers and increased congestive heart failure and renal failure at 24 months followup, comparisons that were unavailable to us owing to specifics of the ACS-NSQIP 1 database.…”

“…As mentioned before, one study identified an increased risk of cardiac complications, of which myocardial infarction was included, in patients with diabetes after operative stabilization of hip fractures [22]. However, no other individual adverse events showed a difference in risk between patients with diabetes and those without diabetes.…”

“…An additional study determined that patients with diabetes were at increased risk of cardiac complications and pressure ulcers after hip fracture surgery, but no greater risk of thromboembolic, wound, or respiratory complications [22]. Furthermore, another study determined there was no difference in any postoperative complication between patients with diabetes and those without at 4 and 12 months followup [10].…”

“…Previous studies evaluating diabetes and operative stabilization of hip fractures have shown an increased risk of postoperative cardiac complications [10,22], renal dysfunction [10,17], urinary retention [1], extended length of hospital stay [22], and hospital readmission within 28 days [14]. Although all valuable contributions, many of these investigations were limited by small sample sizes, restriction to a single-hospital system, or lack of postdischarge followup.…”

Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases

“…They also hypothesized that ER-stress regulation through eIF2a and ATF4 could be a good system for antiosteoporosis [67]. Diabetic patients are more prone to fractures especially that of hip and upper extremities as compared with the non-diabetics [68]. Insulinopenia and hyperglycemia cause low BMD which impairs bone formation [69].…”