Diabetes mellitus and risk of sudden cardiac death: A systematic review and meta-analysis

Zaccardi, Francesco; Khan, Hassan; Laukkanen, Jari A.

doi:10.1016/j.ijcard.2014.08.105

Cited by 58 publications

(48 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A substantial proportion of elderly patients hospitalized for acute myocardial infarction have elevated glucose levels, even in the absence of known diabetes that is associated with a greater risk of 30-day mortality [16]. Several studies have identified DM as a risk factor for SCD [4, 17, 18]. In Paris Prospective Study I, after controlling for several other risk factors, DM was associated with significant Sudden Cardiac Death risk (RR 2.21; 95% confidence interval (CI) 1.1 – 4.44) [18].…”

Section: Diabetes As a Risk Factor For Life-threatening Cardiac Arrhymentioning

confidence: 99%

“…Patients with DM are at increased risk of cardiac arrhythmias that increases predisposition to sudden cardiac death (SCD) [2–4]. ICD therapy has been shown to be effective in aborting life-threatening ventricular arrhythmias and when compared to antiarrhythmic therapy effectively reduce arrhythmic death and all-cause mortality in patients with advanced heart disease at risk for or following survival from an aborted cardiac arrest event [5].…”

Section: Expert Commentarymentioning

confidence: 99%

“…Patients with DM are at increased risk of cardiac arrhythmias including atrial fibrillation and ventricular arrhythmias that increases predisposition to stroke and sudden cardiac death (SCD), respectively [2–4]. Implantable cardioverter defibrillator (ICD), when compared to antiarrhythmic therapy, has been shown to effectively reduce arrhythmic death and all-cause mortality in the selected population with advanced heart disease, whether used for primary prevention of SCD in patients at risk or those who have already survived an aborted cardiac arrest event [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Implantable cardioverter defibrillators in diabetics: efficacy and safety in patients at risk of sudden cardiac death

Shahreyar¹,

Mupiddi

Choudhuri

et al. 2015

Expert Review of Cardiovascular Therapy

View full text Add to dashboard Cite

Summary Diabetes mellitus is a major risk factor for arrhythmogenesis and is associated with a 2-fold increase in all-cause mortality and a 4-fold increase in cardiovascular mortality including sudden cardiac death when compared to nondiabetics. Implantable cardioverter defibrillators (ICD) have been shown to effectively reduce arrhythmic death and all-cause mortality in patients with severe myocardial dysfunction. With a high competing risk of nonarrhythmic cardiac and noncardiac death, survival benefit of ICD in patients with diabetes mellitus could be reduced, but the sub-analysis of diabetic patients in randomized clinical trials provides reassurance regarding a similar beneficial survival effect of ICD and cardiac resynchronization therapy in diabetics, as observed in the overall population with advanced heart disease. In this article, the authors highlight some of the clinical issues related to diabetes, summarize the data on the efficacy of ICD in diabetics when compared to nondiabetics and discuss concerns related to ICD implantation in patients with diabetes.

show abstract

Section: Diabetes As a Risk Factor For Life-threatening Cardiac Arrhymentioning

confidence: 99%

Section: Expert Commentarymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Implantable cardioverter defibrillators in diabetics: efficacy and safety in patients at risk of sudden cardiac death

Shahreyar¹,

Mupiddi

Choudhuri

et al. 2015

Expert Review of Cardiovascular Therapy

View full text Add to dashboard Cite

show abstract

“…All these factors contribute a development of coronary artery disease, diabetic cardiomyopathy, heart failure, arrhythmia, thromboembolism, and risk of suddenly death [8,[19][20][21][22]. Appropriately, biomarkers might reflect appropriate faces of multifactorial pathogenesis of disease and predict CV mortality.…”

Section: Biomarkers and CV Complications In Diabeticsmentioning

confidence: 99%

Cardiovascular Biomarkers in Routine Screening of Diabetic Pati ents

Berezin¹

2015

Clin Med Biochemistry Open Access

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is one of the most prevalent metabolic diseases that associated with increased risk for cardiovascular (CV) diseases and newly CV events. Although CV risk assessment is incorporated in primary and secondary prevention strategies to improve morbidity and mortality that are applied in diabetic patient, it is important to stratify individuals at high CV risk not just prior diabetic complication, but at early stages of development of the CV diseases. The aim of the editorial comment is to discuss possible predictive role of cardiac biomarkers in T2DM. CV biomarkers may contribute to improved prediction of mortality and CV events in T2DM. It has suggested that measurement of serum levels of hs-CRP, galectin-3, natriuretic peptides, fibroblast growth factor-23, α-klotho, and hs-cTnT probably allows the screening of diabetes patients at risk of CV events. Future directions are associated with discovering of novel biomarkers and optimal combinations of recently used markers to provide additional prognostic information beyond what is available with other traditional CV risk factors.

show abstract

“…80% cases of SCD occur as a result of coronary artery disease (CAD); consequently, risk factors of CAD also predispose to SCD [4]. Other important risk factors for SCD are diabetes mellitus (DMt2) [5] and heart failure (HF) [6] . In most cases SCDs result from ventricular tachycardia (VT) and ventricular fibrillation (VF) [7] .…”

Section: Introductionmentioning

confidence: 99%