Diabetes mellitus and the female reproductive system tumors

Sharafutdinova, K. I.; Shlyapina, V. S.; Baeva, A. I.; Timurshin, A. A.; Sabanaeva, I. E.; Nakieva, A. G.; Kalashnikova, M. F.; Khabibov, M. N.

doi:10.14341/probl13282

Cited by 3 publications

References 58 publications

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Influence of obesity on the formation and development of cancer. Obesity and metabolism

Mustafina,

Vinter,

Alferova

2024

Obes. metabol.

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It has now been shown that overweight and obesity are associated with the development of at least 13 types of cancer, including cancer of the breast, colon and rectum, endometrium, esophagus (adenocarcinoma), gallbladder, stomach, kidney (renal cell), liver, ovaries, pancreas and thyroid glands, as well as multiple myeloma. Obesity-related cancers account for about 40% of all cancers. Thus, obesity is ahead of smoking as the most common modifiable risk factor for carcinogenesis. This review collects the latest data on the impact of obesity phenotypes on the risk of developing cancer, including a discussion of the contribution of the metabolically healthy obesity phenotype (MHO) to tumorigenesis. Possible mechanisms contributing to the emergence and progression of cancer are analyzed, for example: stimulation of cell proliferation, evasion of growth suppressors, inhibition of apoptosis and provision of replicative immortality, induction of angiogenesis, activation of invasion and metastasis, influence on genome instability, as well as chronic low-grade inflammation that contributes to the development of cancer. Understanding how obesity influences the above mechanisms may facilitate the development of new cancer prevention and treatment strategies for obese populations.

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Influence of obesity on the formation and development of cancer. Obesity and metabolism

Mustafina,

Vinter,

Alferova

2024

Obes. metabol.

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Trends in the Female Reproductive System Cancer Incidence in China from 2005 to 2018 and Prediction to 2035

Zhou,

Shao,

Dong

et al. 2024

Preprint

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Biochemical bases of the organoprotective properties of metformin

Teplova,

Titova,

Tenchurina

2024

jour

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Metformin is recognized as the "gold standard" for the treatment of type 2 diabetes mellitus (DM2). Its hypoglycemic properties are realized by reducing insulin resistance, contributing to the utilization of glucose in liver cells, muscles and adipose tissue; suppression of gluconeogenesis in the liver. Due to the wide range of biochemical targets of its pharmacological action, the scientific community actively discusses the use of metformin as an organoprotective drug. Now, the beneficial effect of metformin on the course of neuropathy, diseases of the cardiovascular system, normalization of the composition and metabolic activity of the intestinal microbiota, the course of metabolically associated fatty liver disease has already been proven, the nephroprotective effect has also been proven, and the study of the anti-oncogenic properties of metformin continues. The number of publications devoted to research on the positive effects of metformin on various organs and systems is actively increasing, and data on the identification of new effects are regularly published. The purpose of this literature review is to analyze the pleiotropic effects of metformin at the level of biochemical interactions for a more detailed understanding of the principles of their implementation.

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Diabetes mellitus and the female reproductive system tumors

Cited by 3 publications

References 58 publications

Influence of obesity on the formation and development of cancer. Obesity and metabolism

Influence of obesity on the formation and development of cancer. Obesity and metabolism

Trends in the Female Reproductive System Cancer Incidence in China from 2005 to 2018 and Prediction to 2035

Biochemical bases of the organoprotective properties of metformin

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