Diabetes Mellitus and the Incidence of Colorectal Cancer: An Updated Systematic Review and Meta-Analysis

Deng, Ling-Xiao; Gui, Zhifu; Zhao, Liandong; Wang, Jianping; Shen, Lizong

doi:10.1007/s10620-012-2055-1

Cited by 182 publications

(132 citation statements)

References 42 publications

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“…Twelve of these articles also included meta-analysis of observational studies [4, 5, 10, 12, 18-21, 27, 49, 55, 62]. Another 14 articles on meta-analyses of observational studies were also identified [63][64][65][66][67][68][69][70][71][72][73][74][75][76] ( Table 1). The meta-analyses addressed diverse medications including antidiabetics, antihyperlipidemics, antihypertensives, antirheumatics, drugs for osteoporosis, and drugs for other conditions.…”

Section: Discussionmentioning

confidence: 99%

“…At least one other meta-analysis [72] shows no risks or decreased risks with these antihypertensive agents. Insulin therapy seemingly has the strongest evidence for an association with increased overall cancer risk, and this is also reflected in significant associations with specific cancer types, in particular colorectal and pancreatic cancers which have each been documented in two separate meta-analyses [63][64][65]. However, a recent large randomized, trial on over 12 000 randomized participants (ORIGIN) found no increased risk of cancer with insulin versus standard care over a median follow-up of 6.2 years [83].…”

Section: Discussionmentioning

confidence: 99%

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Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses

et al. 2014

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“…Finally, IGFBP1 methylation levels in peripheral blood were recently found increased in type II diabetic men compared with normal glucose-tolerant individuals (12). Type II diabetics as compared with nondiabetics have been found to be at an increased risk of colorectal cancer (13).…”

Section: Introductionmentioning

confidence: 99%

Body Size, Physical Activity, Early-Life Energy Restriction, and Associations with Methylated Insulin-like Growth Factor–Binding Protein Genes in Colorectal Cancer

Simons

Brandt

Stehouwer

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We investigated body size, physical activity, and early-life energy restriction in relation to colorectal tumors with and without methylated insulin-like growth factor-binding protein (IGFBP) genes, which are putative tumor-suppressor genes.Methods: We determined IGFBP2, IGFBP3, and IGFBP7 promoter CpG island hypermethylation in tumors of 733 colorectal cancer cases from the Netherlands Cohort Study (N ¼ 120,852). Participants self-reported lifestyle and dietary factors at baseline in 1986. Using a case-cohort approach (N subcohort ¼ 5,000), we estimated hazard ratios (HR) for colorectal cancer by extent of IGFBP methylation.Results: Comparison of the highest versus lowest sex-specific tertiles of adult body mass index (BMI) gave multivariable-adjusted HRs [95% confidence intervals (CI)] for colorectal cancers with 0 (18.7%), 1 (29.5%), 2 (32.4%), and 3 (19.5%) methylated genes of 1.39 (0.88-2.19), 1.11 (0.77-1.62), 1.67 (1.17-2.38), and 2.07 (1.29-3.33), respectively. Other anthropometric measures and physical activity were not associated with colorectal cancer risk by extent of IGFBP methylation, except height in sex-specific analyses for women. Exposure to energy restriction during the Dutch Hunger Winter versus nonexposure gave HRs (95% CIs) for colorectal cancers with 0, 1, 2, and 3 methylated genes of 1.01 (0.67-1.53), 1.03 (0.74-1.44), 0.72 (0.52-0.99), and 0.50 (0.32-0.78), respectively.Conclusions: Adult BMI, height (in women only), and early-life energy restriction were associated with the risk of having a colorectal tumor characterized by IGFBP methylation.Impact: Body size may particularly increase the risk of IGFBP gene-methylated colorectal tumors; this finding might facilitate more targeted approaches to prevent obesity-related colorectal cancers. Cancer Epidemiol Biomarkers Prev; 23(9); 1852-62. Ó2014 AACR.

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“…Diabetes mellitus is a common chronic disease associated with increased incidence of cancer at various sites (including colon and rectum) compared with general or nondiabetic populations [1][2][3][4]. Pre-existing diabetes at cancer diagnosis is also associated with poorer overall survival in patients with colorectal cancer (CRC) [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Cause-specific mortality in Scottish patients with colorectal cancer with and without type 2 diabetes (2000–2007)

et al. 2013

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Aims/hypothesis The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on (1) survival (overall and cause-specific) in multiple time intervals after diagnosis of colorectal cancer and (2) cause of death. Methods Data from the Scottish Cancer Registry were linked to data from a population-based national diabetes register. All people in Scotland diagnosed with nonmetastatic cancer of the colon or rectum in 2000-2007 were included. The effect of pre-existing type 2 diabetes on survival over four discrete time intervals (<1, 1-2, 3-5 and >5 years) after cancer diagnosis was assessed by Cox regression. Cumulative incidence functions were calculated representing the respective probabilities of death from the competing causes of colorectal cancer, cardiovascular disease, other cancers and any other cause. Results Data were available for 19,505 people with colon or rectal cancer (1,957 with pre-existing diabetes). Causespecific mortality analyses identified a stronger association between diabetes and cardiovascular disease mortality than that between diabetes and cancer mortality. Beyond 5 years after colon cancer diagnosis, diabetes was associated with a detrimental effect on all-cause mortality after adjustment

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Diabetes Mellitus and the Incidence of Colorectal Cancer: An Updated Systematic Review and Meta-Analysis

Abstract: Our findings further support a relationship between diabetes and increased risk of colon and rectal cancer in both women and men, and insulin therapy for diabetes may increase this risk.

Cited by 182 publications

References 42 publications

Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses

Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses

Body Size, Physical Activity, Early-Life Energy Restriction, and Associations with Methylated Insulin-like Growth Factor–Binding Protein Genes in Colorectal Cancer

Cause-specific mortality in Scottish patients with colorectal cancer with and without type 2 diabetes (2000–2007)

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