Diabetes mellitus and the rate of cognitive ageing

Bent, Nuala; Rabbitt, Patrick; Metcalfe, David A.

doi:10.1348/014466500163356

Cited by 33 publications

(19 citation statements)

References 25 publications

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“…Considering this constellation of findings, it would appear that the association of diabetes and hyperleptinemia is likely a function of some degree of leptin resistance, but we have no ability to confirm this with our data. It is interesting to note that recent work has linked diabetes to mild cognitive impairment (Arvanitakis et al, 2006;Bent et al, 2000;Gregg et al, 2000;Nguyen et al, 2002;Yaffe et al, 2004;Yaffe et al, 2006). Indeed, after adjustment for the presence of diabetes, the association between high serum leptin level and less cognitive decline becomes more robust, arguing that diabetes functions as a negative confounder in this study.…”

Section: Discussionmentioning

confidence: 62%

Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

Holden

Lindquist

Tylavsky

et al. 2009

Neurobiology of Aging

204

142

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Leptin is a peptide hormone secreted by adipocytes. It has been shown to modulate production and clearance of amyloid beta (Aβ) in rodent models. We sought to determine if serum leptin was associated with cognitive decline in the elderly.We studied 2871 well-functioning elders, aged 70-79, who were enrolled in a prospective study. Serum leptin concentrations were measured at baseline and analyzed by mean ± 1 SD. Clinically significantly cognitive decline over 4 years was defined as ≥ 5 point drop on the Modified Mini Mental State Exam (3MS).Compared to those in the lower leptin groups, elders in the high leptin group had less cognitive decline, 20.5% vs. 24.7% (OR=0.79 95% CI 0.61-1.02, p=0.07). After adjustment for demographic and clinical variables, including body mass index and total percent body fat, those in the high leptin group had significantly less likelihood of cognitive decline, OR=0.66 (95% CI 0.48-0.91). We conclude that in elderly individuals, higher serum leptin appears to protect against cognitive decline, independent of comorbidites and body fat. HHS Public Access

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Section: Discussionmentioning

confidence: 62%

Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

Holden

Lindquist

Tylavsky

et al. 2009

Neurobiology of Aging

204

142

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“…An overall evaluation of the cognitive function of type 2 diabetic patients indicates, as others have [70][71][72][73] , that their neuropsychological performance is suggestive of accelerated aging. Despite the considerable variability in findings and the multiple interacting factors, type 2 diabetic patients show a general cognitive decline, which is more observable in the areas of verbal memory and processing speed.…”

Section: Interpretation Of Neuropsychological Findings Of Type 2 Diabmentioning

confidence: 99%

The relationships between atherosclerosis, heart disease, type 2 diabetes and dementia

Messier

Awad

Gagnon

2004

Neurological Research

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Type 2 diabetes in the elderly is associated with increased incidence of vascular disease, particularly, atherosclerosis of large blood vessels. Together with other risk factors such as dyslipidemia, atherosclerosis increases the risk for coronary heart disease and stroke. Most studies that have examined the impact of type 2 diabetes and other heart disease risk factors on cognitive functions do not provide evidence that heart disease risk factors (with the possible exception of triglycerides) further increase the likelihood of observing cognitive deficits in diabetic patients. However, none of these studies used imaging techniques to evaluate atherosclerosis or evidence of cerebrovascular disease, such as infarctions. The few studies that have included brain imaging suggest that evidence of cerebrovascular disease further increases the risk for dementia in diabetic patients. The results of longitudinal studies suggest that diabetes is an independent risk factor for cognitive decline and dementia. The pattern of neuropsychological performance observed in type 2 diabetic patients appears to be the result of multiple interacting processes developing over time. In addition to the detrimental effects of protracted impaired glucose regulation on the central nervous system, type 2 diabetes pathology also encompasses the detrimental effects of associated complications such as cerebrovascular disease, which is likely the main cause of the observed processing speed/reaction time decrements.

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“…Muchas veces el posible deterioro no ha sido considerado como tal, ya que puede ser confundido con síntomas atribuibles a las hipoglucemias. Algunos autores han mostrado que el deterioro cognitivo es permanente en la diabetes (Northam et al, 1995;KIamer, 1998;Bent et al 2000;Wessels, et al 2007) Sin embargo, otros estudios discrepan afirmando que el deterioro cognitivo en la diabetes no se produce y cuando esto ocurre, es reversible (Biessels et al 1994, Gschwend, 1995, Biorgaas et al 1997, Austin et al, 1999Kúbiak, 2004). …”

Section: Discussionunclassified

Evaluación neuropsicológica de la diabetes mellitus tipo 1 en la infancia

Fernández

Pérez²,

Arias³

2010

Avances en Diabetología

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Diabetes mellitus and the rate of cognitive ageing

Abstract: Together with other recent studies these data emphasize the need for early detection and effective management of diabetes in older patients.

Cited by 33 publications

References 25 publications

Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

The relationships between atherosclerosis, heart disease, type 2 diabetes and dementia

Evaluación neuropsicológica de la diabetes mellitus tipo 1 en la infancia

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